Results 11 to 20 of about 208,758 (293)

How level and type of deafness affects user perception of multimedia video clips [PDF]

, 2003
Our research investigates the impact that hearing has on the perception of digital video clips, with and without captions, by discussing how hearing loss, captions and deafness type affects user QoP (Quality of Perception).
Ghinea, G, Gulliver, SR
core   +1 more source

SLC26A4-linked CEVA haplotype correlates with phenotype in patients with enlargement of the vestibular aqueduct

BMC Medical Genetics, 2019
Background Recessive mutations of coding regions and splice sites of the SLC26A4 gene cause hearing loss with enlargement of the vestibular aqueduct (EVA).
Janet R. Chao, Parna Chattaraj, Tina Munjal, Keiji Honda, Kelly A. King, Christopher K. Zalewski, Wade W. Chien, Carmen C. Brewer, Andrew J. Griffith   +8 more
doaj   +1 more source

Death agonist antibody against TRAILR2/DR5/TNFRSF10B enhances birinapant anti-tumor activity in HPV-positive head and neck squamous cell carcinomas

Scientific Reports, 2021
Head and neck squamous cell carcinomas (HNSCC) induced by human papillomavirus (HPV) have increased recently in the US. However, the distinct alterations of molecules involved in the death pathways and drug effects targeting inhibitor of apoptosis ...
Yi An, Jun Jeon, Lillian Sun, Adeeb Derakhshan, Jianhong Chen, Sophie Carlson, Hui Cheng, Christopher Silvin, Xinping Yang, Carter Van Waes, Zhong Chen   +10 more
doaj   +1 more source

Behavioral models of tinnitus and hyperacusis in animals

Frontiers in Neurology, 2014
The phantom perception of tinnitus and reduced sound level tolerance associated with hyperacusis, have a high comorbidity and can be debilitating conditions for which there are no widely accepted treatments.
Sarah H Hayes, Kelly E Radziwon, Daniel J Stolzberg, Richard J Salvi   +3 more
doaj   +1 more source

Emx2 regulates hair cell rearrangement but not positional identity within neuromasts

eLife, 2020
Each hair cell (HC) precursor of zebrafish neuromasts divides to form two daughter HCs of opposite hair bundle orientations. Previously, we showed that transcription factor Emx2, expressed in only one of the daughter HCs, generates this bidirectional HC ...
Sho Ohta, Young Rae Ji, Daniel Martin, Doris K Wu   +3 more
doaj   +1 more source

Illumina sequencing of 15 deafness genes using fragmented amplicons [PDF]

, 2014
BACKGROUND: Resequencing of deafness related genes using GS FLX massive parallel sequencing of PCR amplicons spanning selected genes has previously been reported as a successful strategy to discover causal variants.
Coucke, Paul, De Keulenaer, Sarah, De Schrijver, Joachim, Deforce, Dieter, Van Criekinge, Wim, Van Nieuwerburgh, Filip, Vandesompele, Jo   +6 more
core   +1 more source

Characterization of the development of the mouse cochlear epithelium at the single cell level

Nature Communications, 2020
How the development of the cochlear epithelium is regulated is unclear. Here, the authors use single cell RNAseq analysis to provide insight into the transcriptional changes arising during development of the murine cochlear inner and outer hair cells.
Likhitha Kolla, Michael C. Kelly, Zoe F. Mann, Alejandro Anaya-Rocha, Kathryn Ellis, Abigail Lemons, Adam T. Palermo, Kathy S. So, Joseph C. Mays, Joshua Orvis, Joseph C. Burns, Ronna Hertzano, Elizabeth C. Driver, Matthew W. Kelley   +13 more
doaj   +1 more source

Is the outcome of fitting hearing aids to adults affected by whether an audiogram-based prescription formula is individually applied? A systematic review protocol

BMJ Open, 2021
Introduction Hearing aids are typically programmed using the individual’s audiometric thresholds. Developments in technology have resulted in a new category of direct-to-consumer devices, which are not programmed using the individual’s audiometric ...
Kevin J Munro, Ibrahim Almufarrij, Harvey Dillon   +2 more
doaj   +1 more source

Na(V)1.5 sodium channel window currents contribute to spontaneous firing in olfactory sensory neurons [PDF]

, 2014
Olfactory sensory neurons (OSNs) fire spontaneously as well as in response to odor; both forms of firing are physiologically important. We studied voltage-gated Na+ channels in OSNs to assess their role in spontaneous activity.
Dionne, Vincent E., Dupuis, Nicholas D., Finger, Thomas E., Frenz, Christopher T., Hansen, Anne, Levinson, Simon R., Shultz, Nicole   +6 more
core   +1 more source

Enhancing direct cytotoxicity and response to immune checkpoint blockade following ionizing radiation with Wee1 kinase inhibition

OncoImmunology, 2019
Tumor cells activate the G2/M cell cycle checkpoint in response to ionizing radiation (IR) and effector immune cell-derived granzyme B to facilitate repair and survival. Wee1 kinase inhibition reverses the ability of tumor cells to pause at G2/M.
Priya Patel, Lily Sun, Yvette Robbins, Paul E. Clavijo, Jay Friedman, Christopher Silvin, Carter Van Waes, John Cook, James Mitchell, Clint Allen   +9 more
doaj   +1 more source