Results 31 to 40 of about 127,275 (301)

Shedding light on optical cochlear implant progress

EMBO Molecular Medicine, 2020
Electrical cochlear implants (CI) currently lack the frequency and intensity resolution to allow detection of complex sounds in background noise. The use of microscale optoelectronics in conjunction with optogenetics provides a promising direction in CI ...
Siân R Kitcher, Catherine JC Weisz
doaj   +1 more source

On the supposed moral harm of selecting for deafness.

, 2011
This paper demonstrates that accounting for the moral harm of selecting for deafness is not as simple or obvious as the widespread negative response from the hearing community would suggest.
Fahmy, Melissa Seymour
core   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

Altered ABR Waveform Patterns in Tinnitus Patients With Normal Full-Frequency Hearing May Be Induced by Abnormal Middle Ear Muscle Activity Via the Trigeminal Nerve System

Journal of Otolaryngology - Head and Neck Surgery
Importance Evidence regarding the mechanism of tinnitus in patients with normal full-frequency hearing remains limited. This study investigated the auditory brainstem response (ABR) waveform patterns in these patients to address this unmet need, which is
Yun Jiang BM, Tianyi Ni MM, Hongbo Xie MM, Siyi Yang BM, Ziyuan Lin BM, Jian Ruan BM, Min Zhang PhD, Xiuling Lu BSN, Wenjing Zhang BS, Wenjing Su BS, Yuehong Liu PhD, Zhao Han PhD   +11 more
doaj   +1 more source

Sertraline Treatment Can Mimic Niemann‐Pick Type C Biomarker Profile: A Diagnostic Pitfall

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Oxysterols (cholestane‐3β,5α,6β‐triol and 7‐ketocholesterol) and N‐palmitoyl‐O‐phosphocholineserine (PPCS) are sensitive biomarkers for Niemann‐Pick disease type C (NPC) screening. However, false‐positive results occur, with a biomarker profile suggestive of NPC despite the absence of pathogenic variants in genes involved in NPC or ...
Maria Makrygianni, Cecile Pagan, Antony Citterio‐Quentin, Isabelle Rouvet, Giulia Dingeo, Cyril Hanin, Claudine Laurent‐Levinson, Samia Pichard, Bénédicte Héron, Clément Gourguechon, Daniele Mandia, Jerome Guitton, Carole Lacout, Nicolas Schleinitz, Florient Potier, Olivier Flabeau, Elsa Besse‐Pinot, Foudil Lamari, Magali Pettazzoni, Yann Nadjar   +19 more
wiley   +1 more source

Pure word deafness associated with extrapontine myelinolysis

, 2010
Extrapontine myelinolysis and pure word deafness are very uncommon disorders. Here, we report a case of a 19-year-old woman who suffered from osmotic demyelination syndrome with coincidence of typical pure word deafness.
Zhu, Ren-jing, Lv, Zhi-su, Shan, Chun-lei, Luo, Ben-yan, Xu, Ming-wei   +4 more
core   +2 more sources

Multifunctional redox modulator prevents blast-induced loss of cochlear and vestibular hair cells and auditory spiral ganglion neurons

Scientific Reports
Blast wave exposure, a leading cause of hearing loss and balance dysfunction among military personnel, arises primarily from direct mechanical damage to the mechanosensory hair cells and supporting structures or indirectly through excessive oxidative ...
Dalian Ding, Senthilvelan Manohar, Peter F. Kador, Richard Salvi   +3 more
doaj   +1 more source

Determining if T cell antigens are naturally processed and presented on HLA class I molecules

BMC Immunology, 2022
Background Determining T cell responses to naturally processed and presented antigens is a critical immune correlate to determine efficacy of an investigational immunotherapeutic in clinical trials.
Jay Friedman, Sreenivasulu Gunti, Maxwell Lee, Ke Bai, Christian Hinrichs, Clint T. Allen   +5 more
doaj   +1 more source

The impacts of deaf culture on designing with deaf children [PDF]

Proceedings of the 29th Australian Conference on Computer-Human Interaction, 2017
This paper will discuss the impacts Deaf culture and the traits of individual Deafness have on the conduct of co-design with Deaf children. A series of design sessions were undertaken with a design team composed of young Deaf children, the first author as an adult designer, members of an Early Childhood Development Program's staff, and the parents of ...
Jessica Korte, Leigh Ellen Potter, Sue H. Nielsen   +2 more
openaire   +5 more sources

Digital Cognitive Testing in Mitochondrial Disease: Validity and Challenges for Clinical Trial Use

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Primary mitochondrial disease is a group of genetic disorders caused by pathogenic variants in nuclear or mitochondrial DNA, often resulting in progressive neurodegeneration and cognitive decline. Current management is primarily supportive, though recent research offers hope for disease‐modifying treatments in the future.
Oksana Pogoryelova, Jan Smeitink, Herma Renkema, Rosabeth White, Frankie Barton, Rachel Lyon, Jane Newman, Aye Moe, Yi Shiau Ng, Grainne Siobhan Gorman   +9 more
wiley   +1 more source