Results 31 to 40 of about 232,677 (345)

AAV‐Mediated Gene Therapy Restores Hearing in Patients with DFNB9 Deafness

Advancement of science
Mutations in OTOFERLIN (OTOF) lead to the autosomal recessive deafness 9 (DFNB9). The efficacy of adeno‐associated virus (AAV)‐mediated OTOF gene replacement therapy is extensively validated in Otof‐deficient mice.
J. Qi, Fangzhi Tan, Liyan Zhang, Ling Lu, Shanzhong Zhang, Yabo Zhai, Yicheng Lu, Xiao-Yun Qian, Wenxiu Dong, Yinyi Zhou, Ziyu Zhang, Xuehan Yang, Lulu Jiang, Chaorong Yu, Jiancheng Liu, Tian Chen, Lianqiu Wu, Chang Tan, Si-Jie Sun, Huaien Song, Yilai Shu, Lei Xu, Xia Gao, Huawei Li, R. Chai   +24 more
semanticscholar   +1 more source

Nanocomplex-based TP53 gene therapy promotes anti-tumor immunity through TP53- and STING-dependent mechanisms

OncoImmunology, 2018
Loss or mutation of TP53 has been linked to alterations in anti-tumor immunity as well as dysregulation of cell cycle and apoptosis. We explored immunologic effects and mechanisms following restoration of wild-type human TP53 cDNA in murine oral cancer ...
Ellen C. Moore, Lillian Sun, Paul E. Clavijo, Jay Friedman, Joe B. Harford, Anthony D. Saleh, Carter Van Waes, Esther H. Chang, Clint T. Allen   +8 more
doaj   +1 more source

Cellular and Deafness Mechanisms Underlying Connexin Mutation-Induced Hearing Loss – A Common Hereditary Deafness

Frontiers in Cellular Neuroscience, 2015
Hearing loss due to mutations in the connexin gene family, which encodes gap junctional proteins, is a common form of hereditary deafness. In particular, connexin 26 (Cx26, GJB2) mutations are responsible for ~50% of non-syndromic hearing loss, which is ...
Jeffrey C. Wingard, Hong-Bo Zhao
semanticscholar   +1 more source

Deaf cultures: towards decolonisation of body, disability, and deafness

, 2023
The article discusses the concept of disability, body, and deafness in the context of colonialism, and Brahminism. In this paper, I argue that Deafness is not limited to hearing loss, but it's a “social and cultural condition.”
Shubham, Shreeti
core   +1 more source

PD-1 blockade reverses adaptive immune resistance induced by high-dose hypofractionated but not low-dose daily fractionated radiation

OncoImmunology, 2018
Preclinical evidence suggests that high-dose hypofractionated ionizing radiation (IR) can enhance anti-tumor immunity and result in significant tumor control when combined with immune checkpoint blockade (ICB).
Megan Morisada, Paul E. Clavijo, Ellen Moore, Lillian Sun, Michael Chamberlin, Carter Van Waes, James W. Hodge, James B. Mitchell, Jay Friedman, Clint T. Allen   +9 more
doaj   +1 more source

Cerebral lateralisation of first and second languages in bilinguals assessed using functional transcranial Doppler ultrasound [version 2; peer review: 2 approved, 1 not approved]

Wellcome Open Research, 2021
Background: Lateralised language processing is a well-established finding in monolinguals. In bilinguals, studies using fMRI have typically found substantial regional overlap between the two languages, though results may be influenced by factors such as ...
Dorothy V. M. Bishop, Clara R. Grabitz, Sophie C. Harte, Kate E. Watkins, Miho Sasaki, Eva Gutierrez-Sigut, Mairéad MacSweeney, Zoe V. J. Woodhead, Heather Payne   +8 more
doaj   +1 more source

On the supposed moral harm of selecting for deafness.

, 2011
This paper demonstrates that accounting for the moral harm of selecting for deafness is not as simple or obvious as the widespread negative response from the hearing community would suggest.
Fahmy, Melissa Seymour
core   +1 more source

No Effect of Interstimulus Interval on Acoustic Reflex Thresholds

Trends in Hearing, 2019
The acoustic reflex (AR), a longstanding component of the audiological test battery, has received renewed attention in the context of noise-induced cochlear synaptopathy—the destruction of synapses between inner hair cells and auditory nerve fibers ...
Hannah Guest, Kevin J. Munro, Samuel Couth, Rebecca E. Millman, Garreth Prendergast, Karolina Kluk, Carlyn Murray, Chris Plack   +7 more
doaj   +1 more source

Neurobiological insights from the study of deafness and sign language [PDF]

, 2019
The study of deafness and sign language has provided a means of dissociating modality specificity from higher level abstract processes in the brain.
Rudner, M, Mary Rudner, Emil Holmer, Cardin, Velia,, Rönnberg, Jerker,, Rudner, Mary,, Jerker Rönnberg, Holmer, Emil,, Cardin, V, Campbell, R, Velia Cardin, Mairéad MacSweeney, Ronnberg, J, MacSweeney, Mairéad,, Holmer, E, MacSweeney, M, Ruth Campbell, Campbell, Ruth,   +17 more
core   +1 more source

Safety of Daprodustat for the Treatment of Chronic Kidney Disease Anemia: Final Analysis of a Multicenter Postmarketing Surveillance Study in Japan

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This final analysis of a multicenter, prospective postmarketing surveillance study evaluated the safety of daprodustat in patients with chronic kidney disease anemia in routine clinical practice in Japan. Methods Patients who initiated daprodustat between September 2020 and July 2022 were registered.
Tadao Akizawa, Kyomi Kanaya, Kiyomi Aizawa, Masanori Onoki, Hirofumi Ozeki, Kazuko Suzuki, Ai Hayashi, Tomohiko Asamura   +7 more
wiley   +1 more source