Results 1 to 10 of about 1,348 (124)

The impact of age-related hearing loss on structural neuroanatomy: A meta-analysis

Frontiers in Neurology, 2022
This meta-analysis investigated the association between age-related hearing loss and structural neuroanatomy, specifically changes to gray matter volume. Hearing loss is associated with increased risk of cognitive decline.
Kate Slade, Johannes H. Reilly, Kamila Jablonska, El Smith, Lawrence D. Hayes, Christopher J. Plack, Christopher J. Plack, Helen E. Nuttall   +7 more
doaj   +3 more sources

Potential therapeutic role of SIRT1 in age- related hearing loss

Frontiers in Molecular Neuroscience, 2022
Age-related hearing loss (ARHL) is a major public health burden worldwide that profoundly affects the daily life of elderly people. Silent information regulator 1 (SIRT1 or Sirtuin1), known as a regulator of the cell cycle, the balance of oxidation ...
Tingting Zhao, Tingting Zhao, Guangyong Tian, Guangyong Tian   +3 more
doaj   +3 more sources

Redox activation of excitatory pathways in auditory neurons as mechanism of age-related hearing loss

Redox Biology, 2020
Age-related hearing (ARHL) loss affects a large part of the human population with a major impact on our aging societies. Yet, underlying mechanisms are not understood, and no validated therapy or prevention exists.
Francis Rousset, German Nacher-Soler, Marta Coelho, Sten Ilmjarv, Vivianne Beatrix Christina Kokje, Antoine Marteyn, Yves Cambet, Michael Perny, Marta Roccio, Vincent Jaquet, Pascal Senn, Karl Heinz Krause   +11 more
doaj   +3 more sources

Factors associated with responses to hearing screening questions among older adults [PDF]

American Journal of Medicine Open
Background: Systematic screening could promote earlier detection and management of age-related hearing loss (ARHL), but there is limited research to support its implementation.
Lauren K. Dillard, AuD, PhD, Judy R. Dubno, PhD, Meagan Perro, AuD, Allyson V. Drawdy, BS, Sarah Tucker Marrison, MD, PhD, Theodore R. McRackan, MD, MSCR   +5 more
doaj   +2 more sources

Cortical Neuroplasticity and Cognitive Function in Early-Stage, Mild-Moderate Hearing Loss: Evidence of Neurocognitive Benefit From Hearing Aid Use

Frontiers in Neuroscience, 2020
Age-related hearing loss (ARHL) is associated with cognitive decline as well as structural and functional brain changes. However, the mechanisms underlying neurocognitive deficits in ARHL are poorly understood and it is unclear whether clinical treatment
Hannah Anneli Glick, Anu Sharma
doaj   +3 more sources

Short-term hearing aid use reduces auditory cortical responses to speech-in-noise listening among older adults with age-related hearing loss [PDF]

Frontiers in Aging Neuroscience
Age-related hearing loss (ARHL) is an increasingly common feature of aging and has been linked to poorer psychosocial wellbeing and increased dementia risk.
Katherine M. Becker, Patrice Voss, Zaida Escila Martinez-Moreno, Francois Prévost, Anthony Zeitouni, Alejandro Lopez Valdes, Alejandro Lopez Valdes, Alejandro Lopez Valdes, Alejandro Lopez Valdes, Etienne de Villers-Sidani   +9 more
doaj   +2 more sources

Auditory Threshold Variability in the SAMP8 Mouse Model of Age-Related Hearing Loss: Functional Loss and Phenotypic Change Precede Outer Hair Cell Loss

Frontiers in Aging Neuroscience, 2021
Age-related hearing loss (ARHL) is the most common sensory deficit in aging society, which is accompanied by increased speech discrimination difficulties in noisy environments, social isolation, and cognitive decline.
Barbara Peixoto Pinheiro, Youssef Adel, Marlies Knipper, Marcus Müller, Hubert Löwenheim   +4 more
doaj   +3 more sources

Gut-Metabolome-Proteome Interactions in Age-Related Hearing Loss: Insights from Fecal Microbiota Transplantation and Multi-Omics Analyses. [PDF]

Adv Sci (Weinh)
Germ‐free (GF) mice receiving fecal microbiota transplantation (FMT) reveal microbiota‐dependent effects on auditory aging. Integrated metagenomic, metabolomic and proteomic profiling maps gut–inner ear network and highlights 5‐hydroxytryptophan (5‐HTP) as a microbiota‐linked metabolic hub in age‐related hearing loss (ARHL).
Yang T, Gao Z, Huang H, Zhang C, Tang Y, Qu Q, Li H, Ke J, Chen Z, Feng M, Zhou H, Shu Y, Yuan W.   +12 more
europepmc   +2 more sources

Beyond the auditory system: cognitive implications of age-related hearing loss [PDF]

Frontiers in Aging Neuroscience
Age-related hearing loss (ARHL) is one of the most common causes of disability in older adults. It is also frequently associated with neurological and neurodegenerative disorders, including dementia, as well as with stress, anxiety, depression, and ...
Fabiola Paciello, Fabiola Paciello, Anna Pisani, Anna Rita Fetoni, Claudio Grassi, Claudio Grassi   +5 more
doaj   +2 more sources

Upregulation of TRPV2 exacerbates age-related hearing loss by promoting oxidative stress in spiral ganglion neurons [PDF]

Molecular Brain
Age-related hearing loss (ARHL) is a prevalent neurodegenerative condition characterized by the progressive loss of spiral ganglion neurons (SGNs). Although oxidative stress is recognized as a central pathogenic driver of ARHL, the precise molecular ...
Zhidong Zhang, Huan Yin, Huan Cao, Miaomiao An, Yanan Li, Jianwang Yang, Tao Liu, Jiantao Wang, Lei Zhao, Chen Wang, Ruoxiang Miao, Baoshan Wang   +11 more
doaj   +2 more sources