Results 31 to 40 of about 1,348 (124)

Protective Effects of N1-Methylnicotinamide Against High-Fat Diet- and Age-Induced Hearing Loss via Moderate Overexpression of Sirtuin 1 Protein

Frontiers in Cellular Neuroscience, 2021
Age-related hearing loss (ARHL) is the most common form of hearing loss and the predominant neurodegenerative disease associated with aging. Sirtuin 1 (SIRT1) is associated with the most complex physiological processes, including metabolism, cancer onset,
Toru Miwa, Toru Miwa
doaj   +1 more source

Hippocampal Transcriptome-Wide Association Study Reveals Correlations Between Impaired Glutamatergic Synapse Pathway and Age-Related Hearing Loss in BXD-Recombinant Inbred Mice

Frontiers in Neuroscience, 2021
Age-related hearing loss (ARHL) is associated with cognitive dysfunction; however, the detailed underlying mechanisms remain unclear. The aim of this study is to investigate the potential underlying mechanism with a system genetics approach.
Tingzhi Deng, Jingjing Li, Jingjing Li, Jingjing Li, Jian Liu, Fuyi Xu, Fuyi Xu, Xiaoya Liu, Jia Mi, Jonas Bergquist, Jonas Bergquist, Helen Wang, Chunhua Yang, Lu Lu, Xicheng Song, Cuifang Yao, Geng Tian, Qing Yin Zheng   +17 more
doaj   +1 more source

Dietary intake of deuterium oxide decreases cochlear metabolism and oxidative stress levels in a mouse model of age-related hearing loss

Redox Biology, 2022
Age-related hearing loss (ARHL) is the most prevalent sensory disorder in the elderly. Currently, no treatment can effectively prevent or reverse ARHL.
Shule Hou, Penghui Chen, Jingchun He, Junmin Chen, Jifang Zhang, Fabio Mammano, Jun Yang   +6 more
doaj   +1 more source

Connexin 30 deletion exacerbates cochlear senescence and age-related hearing loss

Frontiers in Cell and Developmental Biology, 2022
Pathogenic mutations in the Gjb2 and Gjb6 genes, encoding connexin 26 (Cx26) and connexin 30 (Cx30), respectively, have been linked to the most frequent monogenic hearing impairment, nonsyndromic hearing loss, and deafness DFNB1.
Fabiola Paciello, Fabiola Paciello, Veronica Zorzi, Marcello Raspa, Ferdinando Scavizzi, Claudio Grassi, Claudio Grassi, Fabio Mammano, Fabio Mammano, Anna Rita Fetoni, Anna Rita Fetoni   +10 more
doaj   +1 more source

Association between tinnitus and hearing impairment among older adults with age-related hearing loss: a multi-center cross-sectional study

Frontiers in Neurology
ObjectiveThe relationship between tinnitus in the elderly with hearing loss remains elusive. This study aimed to reveal the association between tinnitus and hearing impairment among older adults with age-related hearing loss (ARHL).MethodsThis cross ...
Zhifeng Chen, Zhifeng Chen, Zhifeng Chen, Yan Lu, Yan Lu, Chenyu Chen, Chenyu Chen, Shaolian Lin, Shaolian Lin, Ting Xie, Xiaoyang Luo, Xiaoyang Luo, Yanchun Lin, Yanchun Lin, Yuqing Chen, Yuqing Chen, Yong Feng, Guanxia Xiong, Xiulan Ma, Chaojun Zeng, Chaojun Zeng, Chaojun Zeng, Chang Lin, Chang Lin, Chang Lin   +24 more
doaj   +1 more source

Understanding the Relationship Between Age-Related Hearing Loss and Alzheimer’s Disease: A Narrative Review

Journal of Alzheimer's Disease Reports, 2022
Evidence suggests that hearing loss (HL), even at mild levels, increases the long-term risk of cognitive decline and incident dementia. Hearing loss is one of the modifiable risk factors for dementia, with approximately 4 million of the 50 million cases ...
Hadeel Y. Tarawneh, Dona M.P. Jayakody, Hamid R. Sohrabi, Ralph N. Martins, Wilhelmina H.A.M. Mulders   +4 more
doaj   +1 more source

Predicting cochlear structural alterations from auditory function in age‐related hearing loss mice based on optical coherence tomography

Journal of Intelligent Medicine, EarlyView.
Abstract With global population aging, age‐related hearing loss has become a major public health concern. Understanding the relationship between auditory functional decline and cochlear structural degeneration is essential for early detection and precise intervention.
Shu Zheng, Zhiqi Li, Junyue Wang, Guangjian Ni   +3 more
wiley   +1 more source

Epac1 Alleviates Senescence in Auditory Hair Cells via the Ferroptosis

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Objectives The aim of this study was to investigate the changes in Epac1 and ferroptosis‐related proteins in aged mice and the House Ear Institute‐Organ of Corti 1 (HEI‐OC1) cells, with the goal of elucidating their potential role in age‐related hearing loss. Methods The expression of Epac1 in the cochlea of C57BL/6J mice was examined by using
Wen‐Jun An, Chen‐Yu Xu, Meng‐Ya Shen, Xiao‐Tao Guo, Chun‐Chen Pan, Jing‐Wu Sun, Xiao‐Min Tang, Jia‐Qiang Sun   +7 more
wiley   +1 more source

Comparative Cochlear–Vestibular Aging Reveals Age‐Aligned Mitochondrial Ultrastructural Burden, Mitophagy–Autophagy Remodeling, Synaptic Uncoupling, and Sensory Functional Decline

Aging Cell, Volume 25, Issue 7, July 2026.
This study maps age‐aligned cochlear and vestibular decline in SAMP8 mice, linking functional impairment with synaptic vulnerability, mitochondrial ultrastructural injury, and autophagy/mitophagy–lysosome transcriptional remodeling. The findings provide an integrated framework for understanding shared inner‐ear aging trajectories.
Jingyi Xie, Xujia Zhang, Jinyi Tian, Yulu Yan, Ke Shi, Yongqi Pan, Yanni Zhang, Zichen Chen, Jianbin Sun, Hui Lv, Jingguo Chen, Xiaoyong Ren, Teru Kamogashira, Xiaotong Zhang, Ying Gao   +14 more
wiley   +1 more source

Advances in GPCRs Associated With Wnt Signaling Within the Auditory System

Medicine Bulletin, Volume 2, Issue 3, Page 280-298, June 2026.
ABSTRACT G protein‐coupled receptors (GPCRs) that interact with the Wnt signaling pathway are pivotal for auditory system homeostasis, as they orchestrate inner ear development, hair cell (HC) regeneration, and hearing preservation. Frizzled (FZD) receptors, the core Wnt‐related GPCRs, bind Wnt ligands and co‐receptors (e.g., LRP5/6) to activate both ...
Liang Wang, Changling Xu, Jiangang Fan, Renjie Chai   +3 more
wiley   +1 more source