Results 51 to 60 of about 1,348 (124)

Hainan Longevity Model, Senile Degeneration, Cognitive Disability and Healthy Longevity

AGING MEDICINE, Volume 9, Issue 1, Page 67-81, February 2026.
Investigating centenarians who exemplify healthy longevity can aid in formulating preventive strategies aimed at achieving health and extending lifespan in the context of population aging. Hainan longevity model (HLM) plays key roles in promoting healthy longevity and provides scientific evidence for achieving healthy longevity in the older population.
Shihui Fu, Jiacai Lin, Qianshuo Liu, Lianbo Gao, Zhirui Li, Feng Lin, Leixing Xie, Xiong Liu, Wenkai Xiao, Qiwei Zhu, Fan Wang, Jin Zheng, Yali Zhao, Xiaolei Chen, Yao Yao, Long Feng   +15 more
wiley   +1 more source

NMNAT1 Activates Autophagy to Delay D‐Galactose‐Induced Aging in Cochlear Hair Cells

Aging Cell, Volume 25, Issue 2, February 2026.
The study presents mechanistic insights into cochlear hair cells aging using cellular and explant models. The assessment into NMNAT1 regulated NAD+ metabolism, autophagy, and aging in ARHL. NMNAT1 overexpression restores autophagic activity and decelerates aging in cochlear hair cells.
Yongjie Wei, Wenqing Yang, Han Wu, Mengdie Kong, Dachuan Fan, Yuhua Zhang, Nan Cheng, Jiawei Du, Lingna Guo, Yuyang Li, Ye Zhang, Qian Dai, Wei Cao, Jianming Yang, Qiaojun Fang   +14 more
wiley   +1 more source

The Age-Related Central Auditory Processing Disorder: Silent Impairment of the Cognitive Ear

Frontiers in Neuroscience, 2019
Age-related hearing loss (ARHL), also called presbycusis, is a progressive disorder affecting hearing functions and among the elderly has been recognized as the third most frequent condition.
Rodolfo Sardone, Petronilla Battista, Francesco Panza, Francesco Panza, Madia Lozupone, Madia Lozupone, Chiara Griseta, Fabio Castellana, Rosa Capozzo, Maria Ruccia, Emanuela Resta, Emanuela Resta, Davide Seripa, Giancarlo Logroscino, Giancarlo Logroscino, Nicola Quaranta   +15 more
doaj   +1 more source

Abnormal Hearing Phenotypes in “Ignorome” Knockout Mice as Predictors of Cognitive Dysfunction

Genes, Brain and Behavior, Volume 25, Issue 1, February 2026.
Using data from the International Mouse Phenotyping Consortium, we analyzed over 9000 knockout mouse lines to test whether sensory impairments predict behavioral abnormalities. Knockouts with abnormal hearing showed higher proportions of behavioral deficits, supporting hearing loss as a potential biomarker of cognitive vulnerability.
Sergio Vicencio‐Jimenez, Micheal L. Dent, Amanda M. Lauer   +2 more
wiley   +1 more source

The Impact of Age-Related Hearing Loss on Working Memory among Older Individuals: An Event-Related Potential Study

Dementia and Geriatric Cognitive Disorders Extra
Introduction: Age-related hearing loss (ARHL) may affect working memory (WM), which impacts problem-solving, decision-making, language comprehension, and learning.
Sankalpa Madashetty, Hari Prakash Palaniswamy, Bellur Rajashekhar   +2 more
doaj   +1 more source

Chronic Low‐Level Lead Exposure Causes Auditory Impairment and Accelerates the Progression of Age‐Related Hearing Loss in C57BL/6J Mice

Aging Cell, Volume 25, Issue 1, January 2026.
Chronic low‐concentration lead exposure accelerates the development of ARHL. Lead exposure mediates damage to cochlear sensory cells via the mitochondrial protease LONP1, leading to irreversible hearing loss. ABSTRACT Heavy metal ion exposure has become a global public health concern.
Xue Bai, Li‐Hua Cheng, Zhi‐Bin Zhou, Kai‐Lang Zhou, Yan‐Peng Fu, Bing Liao, Mei‐Qun Wang, Xu‐Bo Chen, Hong‐Ping Chen, Yue‐Hui Liu, Kai Xu   +10 more
wiley   +1 more source

Cross-modal re-organisation in adults with age related hearing loss (ARHL)

Laryngo-Rhino-Otologie, 2021
S Kerres, B Suchan, JP Thomas, C Völter
openaire   +1 more source

Cross-species validation of a human age-related hearing loss candidate KLHDC7B as essential for mammalian hearing

Communications Biology
Although age-related hearing loss (ARHL) is the most common sensory loss in older adults, underlying mechanisms remain unclear. Recent genome-wide association studies (GWAS) linked variation in several genes with ARHL risk, including KLHDC7B, a gene of ...
Alexandra M. Kaufman, Benjamin Silver, Roberto A. Donnianni, Carlos Aguilar, Lingzi Niu, Daniel Johnson, Anwen Bullen, Alma Corona, Benjamin J. van Soldt, Nilay Vora, Gervasio Batista, Luz Cortes-Burgos, Jacqueline Copeland, Elika Fallah, Norman Zhang, Marina Lehmkuhl, Sarah Cancelarich, Kara Campos, Daniela Di Battista Miani, Jaylen Mumphrey, Susan D. Croll, Johnathon R. Walls, Mary Germino, Michael R. Bowl, Meghan C. Drummond, Sally J. Dawson   +25 more
doaj   +1 more source

The impact of early age-related hearing loss on working memory capacity and speech recognition in noise in middle-aged and older adults

Experimental Gerontology
Purpose: This study aimed to investigate the impact of age-related hearing loss (ARHL) on working memory capacity (WMC) and speech recognition in noise and their relationship in middle-aged and older adults.
Chen-Wei Chang, Yu-chun Chen
doaj   +1 more source

Cutting‐Edge Advancements in Physical Stimulation for Spiral Ganglion Neuron Protection and Regeneration

Advanced NanoBiomed Research, Volume 5, Issue 12, December 2025.
Physical stimulation strategies have emerged as a therapeutic avenue for the regeneration of spiral ganglion neurons. This review explores diverse physical stimulation modalities—including topographical modulation, electrical stimulation, and photostimulation—each operating through distinct mechanisms to regulate SGN biological behavior. By elucidating
Yuhan Bai, Bin Zhang, Hong Cheng, Yunzhu Huang, Xinyue Han, Yangnan Hu, Renjie Chai, Wei Cao   +7 more
wiley   +1 more source