Results 61 to 70 of about 1,348 (124)

Ultrastructural Synaptic Differences in the Central Inferior Colliculus in the 3xTG Mouse Across Three Disease Stages

Journal of Comparative Neurology, Volume 533, Issue 12, December 2025.
Symmetric and asymmetric synapses were significantly downregulated by 50% and 20%, respectively, in the aging inferior colliculus of the Alzheimer's 3xTG mouse model during the emerging disease stage (7–8 months). There was no additional significant loss from the emerging disease stage into the established disease stage.
Jeffrey G. Mellott, Lena M. Dellaria, Madeline Guy, Sean R. Hergenrother, Nick J. Tokar, Dakota Z. Smallridge, Miljan Terzic, Jesse W. Young, Christine M. Dengler‐Crish   +8 more
wiley   +1 more source

Therapeutic Effects of GDF6-Overexpressing Mesenchymal Stem Cells through Upregulation of the GDF15/SIRT1 Axis in Age-Related Hearing Loss

Frontiers in Bioscience-Landmark
Background: It has been reported the therapeutic effects of mesenchymal stem cells (MSCs) on hearing loss. This study explored the therapeutic effects of growth differentiation factor 6 (GDF6) overexpression-induced MSCs (MSCs-GDF6) on
Jiali Liu, Haisen Peng, Yuehui Liu, Chunhua Li, Wen Xie   +4 more
doaj   +1 more source

LoCHAid: An ultra-low-cost hearing aid for age-related hearing loss.

PLoS ONE, 2020
Hearing aids are the primary tool in non-medical rehabilitation for individuals with hearing loss. While the costs of the electronic components have reduced substantially, the cost of a hearing aid has risen steadily to the point that it has become ...
Soham Sinha, Urvaksh D Irani, Vinaya Manchaiah, M Saad Bhamla   +3 more
doaj   +1 more source

Corrigendum: Potential therapeutic role of SIRT1 in age- related hearing loss

Frontiers in Molecular Neuroscience, 2022
Tingting Zhao, Tingting Zhao, Guangyong Tian, Guangyong Tian   +3 more
doaj   +1 more source

Synergistic effects of free radical scavengers and cochlear vasodilators: a new otoprotective strategy for age-related hearing loss

Frontiers in Aging Neuroscience, 2015
The growing increase in age-related hearing loss (ARHL), with its dramatic reduction in quality of life and significant increase in health care costs, is a catalyst to develop new therapeutic strategies to prevent or reduce this aging-associated ...
Juan Carlos eAlvarado, Veronica eFuentes-Santamaría, Pedro eMelgar-Rojas, María LLanos Valero, María Cruz Gabaldón-Ull, Josef M Miller, Josef M Miller, José M Juíz   +7 more
doaj   +1 more source

Altered Fhod3 expression involved in progressive high-frequency hearing loss via dysregulation of actin polymerization stoichiometry in the cuticular plate.

PLoS Genetics
Age-related hearing loss (ARHL) is a common sensory impairment with complex underlying mechanisms. In our previous study, we performed a meta-analysis of genome-wide association studies (GWAS) in mice and identified a novel locus on chromosome 18 ...
Ely Cheikh Boussaty, Yuzuru Ninoyu, Leonardo R Andrade, Qingzhong Li, Ryu Takeya, Hideki Sumimoto, Takahiro Ohyama, Karl J Wahlin, Uri Manor, Rick A Friedman   +9 more
doaj   +1 more source

Age-related hearing loss in older adults: etiology and rehabilitation strategies

Frontiers in Neuroscience
Age-related hearing loss (ARHL) is a prevalent sensory organ disorder among elderly individuals that significantly impacts their cognitive function, psychological well-being, and ability to perform activities of daily living.
Qinzhi Zheng, Qinzhi Zheng, Zhuo Xu, Nan Li, Yueying Wang, Ting Zhang, Jiapeng Jing   +6 more
doaj   +1 more source

Endoplasmic reticulum stress-induced necroptosis promotes cochlear inflammation: Implications for age-related hearing loss

Experimental Gerontology
Age-related hearing loss (ARHL) is the most common sensory disorder associated with human aging. Chronic inflammation is supposed to be an important contributor to ARHL.
Zhongwu Su, Yi Liu, Weijian Zhang, Wenhui Liang, Yuyan Chen, Jinyuan Cao, Yu Liu, Yiqing Zheng, Qi Li   +8 more
doaj   +1 more source

Experimental validation and identification of ferroptosis-associated biomarkers for diagnostic and therapeutic targeting in hearing loss

Frontiers in Aging Neuroscience
ObjectivesFerroptosis, a regulated form of cell death, has attracted significant attention in hearing loss research; however, the role of ferroptosis-related genes remains unclear.
Chenyang Yuan, Tianyu Ma, Mengting Liu, Li Jiang, Gongrui Tang, Qi Hu, Tianhong Zhang   +6 more
doaj   +1 more source

Siglec-1 upregulation and macrophage activation in age-related hearing loss: insights from integrated transcriptomic studies in mice and humans

Frontiers in Cellular Neuroscience
Macrophage activation is closely associated with age-related hearing loss (ARHL), and Siglec-1 may be involved in modulating macrophage activation.
Di Ji, Qian Li, Baiyang Ren, Hongli Lan, Wenqi Zuo, Tao Chen, Xin Gong, Sen Yang, Anchun Deng, Shixun Zhong   +9 more
doaj   +1 more source