Results 11 to 20 of about 1,348 (124)

Advances in pathogenesis, novel therapeutic strategies and interventions for age-related hearing loss [PDF]

Frontiers in Molecular Neuroscience
Age-related hearing loss (ARHL), or presbycusis, represents one of the most prevalent sensory dysfunctions in the elderly people. It is characterized by progressive hearing deterioration that significantly impairs quality of life and increases the risk ...
Zhiyang Wen, Zhiyang Wen, Yinfei Liang, Yinfei Liang, Dongxue Wu, Dongxue Wu, Huiqing Wu, Huiqing Wu, Zhicheng Li, Zhicheng Li, Gendi Yin, Gendi Yin, Xiangli Zeng, Xiangli Zeng   +13 more
doaj   +2 more sources

Is Age-Related Hearing Loss a Modifiable Risk Factor for Cognitive Decline? Mechanisms, Evidence, and Future Directions [PDF]

Audiology Research
Background: Age-related hearing loss (ARHL) is the most common sensory disorder in older adults and has been identified as a potentially modifiable risk factor for cognitive decline and dementia. Increasing evidence suggests that auditory dysfunction may
Giovanni Motta, Giuseppe Tortoriello, Domenico Testa   +2 more
doaj   +2 more sources

Cross-sectional analysis of hearing loss, age and tinnitus severity in a web-recruited cohort of 610 subjects [PDF]

Journal of Otology
Tinnitus the hearing of a sound that has not been produced by any external or internal source, is a rather heterogeneous hearing disorder. Background/Objectives Hearing loss has been shown to be the main risk factor for tinnitus while emotional disorders
María Cuesta, Pedro Cobo
doaj   +2 more sources

Sensorial frailty: age-related hearing loss and the risk of cognitive impairment and dementia in later life

Therapeutic Advances in Chronic Disease, 2019
The peripheral hearing alterations and central auditory processing disorder (CAPD) associated with age-related hearing loss (ARHL), may impact cognitive disorders in older age.
Francesco Panza, Madia Lozupone, Rodolfo Sardone, Petronilla Battista, Marco Piccininni, Vittorio Dibello, Maddalena La Montagna, Roberta Stallone, Pietro Venezia, Angelo Liguori, Gianluigi Giannelli, Antonello Bellomo, Antonio Greco, Antonio Daniele, Davide Seripa, Nicola Quaranta, Giancarlo Logroscino   +16 more
doaj   +2 more sources

Uncovering the genetic relationship between dementia and age‐related hearing loss [PDF]

Alzheimers Dement
Abstract Background Hearing loss is an important modifiable midlife risk factor for dementia. Recent studies have explored a potential genetic relationship between dementia and age‐related hearing loss (ARHL). However, due to variability in phenotype definitions and analysis methods, these studies have not reached a clear consensus on the specific ...
Domelen A, Ahmed S, Vaden K, Dubno J, Drögemöller B.   +4 more
europepmc   +2 more sources

Downregulation of BST2 Rescues Cochlear Nerve Demyelination in Age-Related Hearing Loss via Enhancing Schwann Cell Migration. [PDF]

Aging Cell
The illustration indicates that increased BST2 expression in Schwann cells leads to cochlear nerve demyelination, accelerating hearing loss in ARHL. The upregulation of BST2 reduces POU6F1 expression by activating the NF‐κB pathway, which impairs MPZ transcription and Schwann cell migration, ultimately contributing to neural demyelination in ARHL ...
Liu M, Li Q, Cao H, Yin H, Yang J, Liu T, Wang J, Zhao L, Wang B.   +8 more
europepmc   +2 more sources

E2F1-mediated 53BP2 lactylation stabilizes p53 to induce cochlear hair cell apoptosis in mouse age-related hearing loss [PDF]

Clinical Epigenetics
Age-related hearing loss (ARHL) is a prevalent sensory deficit characterized by cochlear hair cell apoptosis, yet the underlying epigenetic mechanisms remain unclear.
Xiaoqin Luo, Jun Liu, Chanyuan Zhang, Wei Yuan, Gang Qin   +4 more
doaj   +2 more sources

Detection of Age-Related Hearing Losses (ARHL) via Transient-Evoked Otoacoustic Emissions.

Clinical interventions in aging, 2020
The objective of the study was to identify subjects presenting hearing deficits, specifically age-related hearing losses (ARHL), via objective assessment methodologies.Initially, 259 subjects (165 men, 94 women) were enrolled in the study. After the application of inclusion criteria, the final number was reduced to 88 subjects (49.8 ± 19.1 ys ...
Zimatore G, Cavagnaro M, Skarzynski PH, Fetoni AR, Hatzopoulos S   +4 more
openaire   +7 more sources

Early Noise-Induced Hearing Loss Accelerates Presbycusis Altering Aging Processes in the Cochlea

Frontiers in Aging Neuroscience, 2022
Several studies identified hearing loss as a risk factor for aging-related processes, including neurodegenerative diseases, as dementia and age-related hearing loss (ARHL).
Anna Rita Fetoni, Anna Rita Fetoni, Anna Rita Fetoni, Anna Pisani, Rolando Rolesi, Rolando Rolesi, Fabiola Paciello, Fabiola Paciello, Andrea Viziano, Arturo Moleti, Renata Sisto, Diana Troiani, Gaetano Paludetti, Gaetano Paludetti, Claudio Grassi, Claudio Grassi   +15 more
doaj   +1 more source

High-Frequency Hearing Loss Is Associated With Anxiety and Brain Structural Plasticity in Older Adults

Frontiers in Aging Neuroscience, 2022
Age-related hearing loss (ARHL) is a kind of symmetrical and slow sensorineural hearing loss, which is a common condition in older adults. The characteristic of ARHL is hearing loss beginning in the high-frequency region and spreading toward low ...
Wen Ma, Yue Zhang, Xiao Li, Siqi Liu, Yuting Gao, Jing Yang, Longji Xu, Hudie Liang, Fuxin Ren, Fei Gao, Yao Wang, Yao Wang   +11 more
doaj   +1 more source