Results 71 to 80 of about 53,995 (223)

Single Cell and Single Nucleus RNA-Seq Reveal Cellular Heterogeneity and Homeostatic Regulatory Networks in Adult Mouse Stria Vascularis

Frontiers in Molecular Neuroscience, 2019
The stria vascularis (SV) generates the endocochlear potential (EP) in the inner ear and is necessary for proper hair cell mechanotransduction and hearing.
Soumya Korrapati, Ian Taukulis, Rafal Olszewski, Madeline Pyle, Shoujun Gu, Riya Singh, Carla Griffiths, Daniel Martin, Erich Boger, Robert J. Morell, Michael Hoa   +10 more
doaj   +1 more source

Genetic Hearing Loss Associated With Autoinflammation

Frontiers in Neurology, 2020
Sensorineural hearing loss can result from dysfunction of the inner ear, auditory nerve, or auditory pathways in the central nervous system. Sensorineural hearing loss can be associated with age, exposure to ototoxic drugs or noise, or mutations in ...
Hiroshi Nakanishi, Hiroshi Nakanishi, Pragya Prakash, Taku Ito, Taku Ito, H. Jeffrey Kim, Carmen C. Brewer, Danielle Harrow, Isabelle Roux, Seiji Hosokawa, Andrew J. Griffith   +10 more
doaj   +1 more source

Long‐Lasting Auditory and Vestibular Recovery Following Gene Replacement Therapy in a Novel Usher Syndrome Type 1c Mouse Model

Advanced Science, EarlyView.
This study shows that gene replacement therapy using the AAV2/Anc80L65 virus can successfully restore hearing and balance in Ush1c knockout mice. The treatment leads to lasting improvements in both auditory and vestibular functions, highlighting its potential as a therapeutic approach for genetic hearing loss and vestibular disorders in humans ...
Weinan Du, Jun Huang, Aizhen Zhang, Fangfang Zhao, Tianwen Chen, Quinn M. McDermott, Tony Zheng, Haibo Wang, Rongli Zhang, Xiaolin Zhang, Jerome Allison, Hong Zhu, Wu Zhou, Qing Yin Zheng   +13 more
wiley   +1 more source

Heritability and complex segregation analysis of deafness in Jack Russell Terriers

BMC Veterinary Research, 2007
Background The association between patterns of pigmentation and deafness in the dog has a long-documented history, with reports dating back over one hundred years.
Strain George M, Cargill Edward J, Famula Thomas R   +2 more
doaj   +1 more source

The Reconstruction of Peripheral Auditory Circuit: Recent Advances and Future Challenges

Advanced Science, EarlyView.
This paper summarizes the potential of biomaterials, stem cells, and gene editing technologies in the regeneration of inner ear hair cells, spiral ganglion neurons, and inner ear organoids. Challenges and potential developments are discussed and explored.
Zhe Li, Ying Zhang, Zhenyu Xiao, Jieyu Qi   +3 more
wiley   +1 more source

TMC1 and TMC2 Localize at the Site of Mechanotransduction in Mammalian Inner Ear Hair Cell Stereocilia

Cell Reports, 2015
Mechanosensitive ion channels at stereocilia tips mediate mechanoelectrical transduction (MET) in inner ear sensory hair cells. Transmembrane channel-like 1 and 2 (TMC1 and TMC2) are essential for MET and are hypothesized to be components of the MET ...
Kiyoto Kurima, Seham Ebrahim, Bifeng Pan, Miloslav Sedlacek, Prabuddha Sengupta, Bryan A. Millis, Runjia Cui, Hiroshi Nakanishi, Taro Fujikawa, Yoshiyuki Kawashima, Byung Yoon Choi, Kelly Monahan, Jeffrey R. Holt, Andrew J. Griffith, Bechara Kachar   +14 more
doaj   +1 more source

Deciphering Auditory Hyperexcitability in Otogl Mutant Mice Unravels an Auditory Neuropathy Mechanism

Advanced Science, EarlyView.
By investigating auditory hyperexcitability in a mouse model for hereditary deafness, this study identified a subpopulation of afferent neurons of the auditory nerve marked by Otogl expression. Despite their apparently normal hearing, Otogl+/− mice display poor activation of afferent neurons processing loud sounds and an elevation of the middle the ear
Mathilde Gagliardini, Sabrina Mechaussier, Carolina Campos Pina, Monica Morais, Olivier Postal, Philippe Jean, Typhaine Dupont, Amrit Singh‐Estivalet, Shéhanie Udugampolage, Cyril Scandola, Elisabeth Verpy, Baptiste Libé‐Philippot, Talya C. Inbar, Joanna Schwenkgrub, Carla Maria Barbosa Spinola, Raphaël Etournay, Aziz El‐Amraoui, Brice Bathellier, Adeline Mallet, Sedigheh Delmaghani, Fabrice Giraudet, Christine Petit, Boris Gourévitch, Paul Avan, Nicolas Michalski   +24 more
wiley   +1 more source

Conditional Overexpression of Serpine2 Promotes Hair Cell Regeneration from Lgr5+ Progenitors in the Neonatal Mouse Cochlea

Advanced Science, EarlyView.
This study indicates that Serpine2 plays a pivotal role in hair cell (HC) regeneration from Lgr5+ progenitors in the neonatal mouse cochlea. Conditional overexpression of Serpine2 in cochlear Lgr5+ progenitors results in a significantly increased number of ectopic HCs, particularly ectopic inner HCs, and these HCs are likely derived from Lgr5 ...
Hairong Xiao, Jiheng Wu, Lixuan Huang, Ying Ma, Leilei Wu, Yanqin Lin, Zixuan Ye, Xin Tan, Xujun Tang, Wei Tong, Mingchen Dai, Yintao Wang, Xia Sheng, Renjie Chai, Shasha Zhang   +14 more
wiley   +1 more source

The genetics of deafness in domestic animals

Frontiers in Veterinary Science, 2015
Although deafness can be acquired throughout an animal’s life from a variety of causes, hereditary deafness, especially congenital hereditary deafness, is a significant problem in several species.
George M Strain
doaj   +1 more source

Design and Implementation of a Virtual 3D Educational Environment to improve Deaf Education [PDF]

arXiv, 2020
Advances in NLP, knowledge representation and computer graphic technologies can provide us insights into the development of educational tool for Deaf people. Actual education materials and tools for deaf pupils present several problems, since textbooks are designed to support normal students in the classroom and most of them are not suitable for people
arxiv