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BIOLOGICAL HALF‐LIVES AND ORGAN DISTRIBUTION OF TRITIATED 8‐LYSINE‐VASOPRESSIN AND 1‐DEAMINO‐8‐D‐ARGININE‐VASOPRESSIN IN BRATTLEBORO RATS [PDF]
Annals of the New York Academy of Sciences, 1982 The biological half-lives and organ distribution of tritiated 8-lysine-vasopressin and 1-deamino-8-D-arginine-vasopressin were determined in R-Amsterdam rats and in homozygous and heterozygous Brattleboro rats with hereditary central diabetes insipidus. It was found that the biological half-lives of [3H]LVP and [3H]dDAVP in the Brattleboro rats did not
Janáky Tamás, Laczi F., László F.A.
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Acta Endocrinologica, 1985
Abstract. A sensitive and specific radioimmunoassay for 1-deamino-8-d-arginine vasopressin (DDAVP) was developed. Plasma concentrations of DDAVP after intragastric administration were determined in non-fasted rats and a dose-related increase in plasma levels was obtained.
S, Lundin, P, Melin, H, Vilhardt
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Abstract. A sensitive and specific radioimmunoassay for 1-deamino-8-d-arginine vasopressin (DDAVP) was developed. Plasma concentrations of DDAVP after intragastric administration were determined in non-fasted rats and a dose-related increase in plasma levels was obtained.
S, Lundin, P, Melin, H, Vilhardt
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Treatment of diabetes insipidus with 1-deamino-8-d-arginine vasopressin.
Acta medica Academiae Scientiarum Hungaricae, 1976The effect on water metabolism of 1-deamino-8-D-arginine vasopressin and lysine vasopressin have been studied and compared in 20 vasopressin-sensitive and 2 ADH-resistant diabetes insipidus patients. In every case of ADH-sensitive diabetes insipidus, diuresis decreased and the urinary osmolality increased more markedly and for a longer time with the ...
L, Czakó, G, Mezei, F A, László
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Experientia, 1969
Die Synthese und Resultate einer vorlaufigen biologischen Prufung von Desamino-dicarba-Argvasopressin, einem Neurohypophysenhormon-Analogon, in dem die Schwefelbrucke durch eine athylengruppe ersetzt ist, werden beschrieben.
S, Hase, T, Morikawa, S, Sakakibara
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Die Synthese und Resultate einer vorlaufigen biologischen Prufung von Desamino-dicarba-Argvasopressin, einem Neurohypophysenhormon-Analogon, in dem die Schwefelbrucke durch eine athylengruppe ersetzt ist, werden beschrieben.
S, Hase, T, Morikawa, S, Sakakibara
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Desmopressin Acetate (1-Deamino-8-D-arginine vasopressin, DDAVP) Response Test
1989Exogenously administered desmopressin acetate (1-deamino-S-D-arginine vasopressin, DDAVP) fails to lessen the diuresis in either congenital or acquired nephrogenic diabetes insipidus. These disorders are characterised by renal tubular end-organ resistance to vasopressin, thus differentiating them from hypothalamic/pituitary diabetes insipidus, in which
P. T. Lascelles, D. Donaldson
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Effect of 1-Deamino-8-D-Arginine Vasopressin on the Prolonged Bleeding Time in Chronic Renal Failure
Nephron, 2008The prolonged bleeding times of 12 patients with chronic renal failure were significantly shortened at 1 and 2 h after an infusion of 0.4 µg/kg 1-deamino-8-D-arginine vasopressin (DDAVP). In 5 of these patients, the bleeding times 24 h after infusion had returned to approximate baseline values, suggesting that the effect of DDAVP is a temporary one ...
A J, Watson, J A, Keogh
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Acta Endocrinologica, 1986
Abstract. By using a specific radioimmunoassay for 1-deamino-8-D-arginine vasopressin (DDAVP), plasma concentrations were measured in rabbit plasma at various times after intra-gastrointestinal injections. Five anatomically distinct regions were employed to administer the peptide, namely: the stomach, the duodenum, the mid-part of the ileum, the ileo ...
S, Lundin, H, Vilhardt
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Abstract. By using a specific radioimmunoassay for 1-deamino-8-D-arginine vasopressin (DDAVP), plasma concentrations were measured in rabbit plasma at various times after intra-gastrointestinal injections. Five anatomically distinct regions were employed to administer the peptide, namely: the stomach, the duodenum, the mid-part of the ileum, the ileo ...
S, Lundin, H, Vilhardt
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The antidiuretic action of 1-deamino-8-D-arginine vasopressin (DDAVP) in man.
International journal of clinical pharmacology and biopharmacy, 19761. After administration of a new vasopressin analogue (DDAVP), a marked and prolonged antidiuresis occurred in 10 patients with pituitary diabetes insipidus. 2. The antidiuretic effects of single intravenous doses of 0.04--24 mug DDAVP and single intranasal doses of 5--320 mug DDAVP were investigated. Time curves of the antidiuretic responses expressed
J P, Radó +5 more
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Hoppe-Seyler's Zeitschrift fur physiologische Chemie, 1983
The synthesis of three reactive analogues of [1,6-alpha-aminosuberic acid, 8-arginine]-vasopressin ([Asu1,6,Arg8]vasopressin) is described. Two peptide hormone analogues contain in the p-position of Phe2 the azido or 3-(3-methyl-3-diazirinyl)propanoylamino residue, which can be converted by photoactivation into nitrenes and carbenes, respectively.
F, Fahrenholz +3 more
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The synthesis of three reactive analogues of [1,6-alpha-aminosuberic acid, 8-arginine]-vasopressin ([Asu1,6,Arg8]vasopressin) is described. Two peptide hormone analogues contain in the p-position of Phe2 the azido or 3-(3-methyl-3-diazirinyl)propanoylamino residue, which can be converted by photoactivation into nitrenes and carbenes, respectively.
F, Fahrenholz +3 more
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