1-Deamino-8-D-Arginine Vasopressin as a Therapy for the Bleeding Diathesis of Renal Failure
American Journal of Nephrology, 2008The treatment of the bleeding diathesis of renal failure remains unsatisfactory. 1-Deamino-8-D-arginine vasopressin (DDAVP) has recently been shown to shorten the prolonged bleeding time of renal failure and may as a result diminish the risk of clinical hemorrhage. We describe 2 cases where DDAVP was used successfully in the management of hemorrhage in
A J, Watson, J A, Keogh
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Production of porcine antibodies with high specificity to [8-D-arginine] deamino-vasopressin (dDAVP)
Experientia, 1977The development of a specific radioimmunoassay for [8-D-arginine] deamino-vasopressin (dDAVP) is described.
J, Slaininová, T, Barth, F, Franĕk
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BIOLOGICAL HALF‐LIVES AND ORGAN DISTRIBUTION OF TRITIATED 8‐LYSINE‐VASOPRESSIN AND 1‐DEAMINO‐8‐D‐ARGININE‐VASOPRESSIN IN BRATTLEBORO RATS [PDF]
The biological half-lives and organ distribution of tritiated 8-lysine-vasopressin and 1-deamino-8-D-arginine-vasopressin were determined in R-Amsterdam rats and in homozygous and heterozygous Brattleboro rats with hereditary central diabetes insipidus. It was found that the biological half-lives of [3H]LVP and [3H]dDAVP in the Brattleboro rats did not
Janáky Tamás, Laczi F., László F.A.
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BIOLOGICAL HALF-LIFE AND ORGAN DISTRIBUTION OF [3H]1-DEAMINO-8-
Abstract The biological half-life of synthetic, radiochemically pure, biologically active [3H]1-deamino-8-d-arginine-vasopressin (dDAVP) in rats was found to be 5·33 ± 0·28 (s.e.m.) min in the initial, transitional, fast phase and 56·28 ± 3·27 min in the second, slow phase.
László F A +3 more
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Response to 1-Deamino-8-D-Arginine Vasopressin in von Willebrand Disease
Haemostasis, 2009The synthetic agent, l-deamino-8-D-arginine vasopressin (DDAVP), is generally regarded to be the treatment of choice for persons with type I von Willebrand disease (vWD), and may be useful in type IIA vWD as well. Several formulations of the drug are available, including a highly concentrated intranasal spray formulation which is ideal for home use ...
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Abstract. A sensitive and specific radioimmunoassay for 1-deamino-8-d-arginine vasopressin (DDAVP) was developed. Plasma concentrations of DDAVP after intragastric administration were determined in non-fasted rats and a dose-related increase in plasma levels was obtained.
S, Lundin, P, Melin, H, Vilhardt
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Treatment of diabetes insipidus with 1-deamino-8-d-arginine vasopressin.
Acta medica Academiae Scientiarum Hungaricae, 1976The effect on water metabolism of 1-deamino-8-D-arginine vasopressin and lysine vasopressin have been studied and compared in 20 vasopressin-sensitive and 2 ADH-resistant diabetes insipidus patients. In every case of ADH-sensitive diabetes insipidus, diuresis decreased and the urinary osmolality increased more markedly and for a longer time with the ...
L, Czakó, G, Mezei, F A, László
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Effect of 1-Deamino-8-D-Arginine Vasopressin on the Prolonged Bleeding Time in Chronic Renal Failure
Nephron, 2008The prolonged bleeding times of 12 patients with chronic renal failure were significantly shortened at 1 and 2 h after an infusion of 0.4 µg/kg 1-deamino-8-D-arginine vasopressin (DDAVP). In 5 of these patients, the bleeding times 24 h after infusion had returned to approximate baseline values, suggesting that the effect of DDAVP is a temporary one ...
A J, Watson, J A, Keogh
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Die Synthese und Resultate einer vorlaufigen biologischen Prufung von Desamino-dicarba-Argvasopressin, einem Neurohypophysenhormon-Analogon, in dem die Schwefelbrucke durch eine athylengruppe ersetzt ist, werden beschrieben.
S, Hase, T, Morikawa, S, Sakakibara
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Desmopressin Acetate (1-Deamino-8-D-arginine vasopressin, DDAVP) Response Test
1989Exogenously administered desmopressin acetate (1-deamino-S-D-arginine vasopressin, DDAVP) fails to lessen the diuresis in either congenital or acquired nephrogenic diabetes insipidus. These disorders are characterised by renal tubular end-organ resistance to vasopressin, thus differentiating them from hypothalamic/pituitary diabetes insipidus, in which
P. T. Lascelles, D. Donaldson
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