Results 1 to 10 of about 10,693,133 (406)

Copper induces cell death by targeting lipoylated TCA cycle proteins

Science, 2022
Copper is an essential cofactor for all organisms, and yet it becomes toxic if concentrations exceed a threshold maintained by evolutionarily conserved homeostatic mechanisms. How excess copper induces cell death, however, is unknown.
Peter Tsvetkov, S. Coy, Boryana Petrova, Margaret B. Dreishpoon, A. Verma, M. Abdusamad, J. Rossen, Lena M Joesch-Cohen, Ranad Humeidi, R. Spangler, J. Eaton, Evgeni M. Frenkel, M. Kocak, S. M. Corsello, S. Lutsenko, Naama Kanarek, S. Santagata, T. Golub   +17 more
semanticscholar   +1 more source

Sex-based differences in natural killer T cell-mediated protection against diet-induced steatohepatitis in Balb/c mice

Biology of Sex Differences, 2023
Background Metabolic dysfunction-associated steatotic liver disease (MASLD) is prevalent in Western countries, evolving into metabolic dysfunction-associated steatohepatitis (MASH) with a sexual dimorphism. Fertile women exhibit lower MASLD risk than men,
Carlos Cuño-Gómiz, Estefanía de Gregorio, Anna Tutusaus, Patricia Rider, Nuria Andrés-Sánchez, Anna Colell, Albert Morales, Montserrat Marí   +7 more
doaj   +1 more source

The ever‐increasing importance of cancer as a leading cause of premature death worldwide

Cancer, 2021
The relative importance of cardiovascular disease (CVD) and cancer as leading causes of premature death are examined in this communication. CVD and cancer are now the leading causes in 127 countries, with CVD leading in 70 countries (including Brazil and
F. Bray, M. Laversanne, E. Weiderpass, I. Soerjomataram   +3 more
semanticscholar   +1 more source

Risk Factors Associated With Acute Respiratory Distress Syndrome and Death in Patients With Coronavirus Disease 2019 Pneumonia in Wuhan, China

Journal of Emergency Medicine, 2020
Importance Coronavirus disease 2019 (COVID-19) is an emerging infectious disease that was first reported in Wuhan, China, and has subsequently spread worldwide.
Chao-min Wu, Xiaoyan Chen, Yanping Cai, Jia’an Xia, Xiaoping Zhou, Shan Xu, Hanping Huang, Li Zhang, Xia Zhou, C. Du, Yuye Zhang, Juan Song, Sijiao Wang, Yencheng Chao, Zeyong Yang, Jie Xu, Xin Zhou, Dechang Chen, W. Xiong, Lei Xu, Feng Zhou, Jinjun Jiang, C. Bai, Junhua Zheng, Yuanlin Song   +24 more
semanticscholar   +1 more source

OpenSAFELY: factors associated with COVID-19 death in 17 million patients

Nature, 2020
Coronavirus disease 2019 (COVID-19) has rapidly affected mortality worldwide1. There is unprecedented urgency to understand who is most at risk of severe outcomes, and this requires new approaches for the timely analysis of large datasets.
E. Williamson, A. Walker, K. Bhaskaran, S. Bacon, C. Bates, C. Morton, H. Curtis, A. Mehrkar, D. Evans, P. Inglesby, J. Cockburn, H. Mcdonald, B. Mackenna, L. Tomlinson, I. Douglas, C. Rentsch, R. Mathur, A. Wong, R. Grieve, D. Harrison, H. Forbes, A. Schultze, R. Croker, J. Parry, F. Hester, S. Harper, R. Perera, S. Evans, L. Smeeth, B. Goldacre   +29 more
semanticscholar   +1 more source

Non Coding RNAs as Regulators of Wnt/β-Catenin and Hippo Pathways in Arrhythmogenic Cardiomyopathy

Biomedicines, 2022
Arrhythmogenic cardiomyopathy (ACM) is an inherited cardiomyopathy histologically characterized by the replacement of myocardium by fibrofatty infiltration, cardiomyocyte loss, and inflammation.
Marina Piquer-Gil, Sofía Domenech-Dauder, Marta Sepúlveda-Gómez, Carla Machí-Camacho, Aitana Braza-Boïls, Esther Zorio   +5 more
doaj   +1 more source

Prostate apoptosis response-4 and tumor suppression: it’s not just about apoptosis anymore

Cell Death and Disease, 2021
The tumor suppressor prostate apoptosis response-4 (Par-4) has recently turned ‘twenty-five’. Beyond its indisputable role as an apoptosis inducer, an increasing and sometimes bewildering, new roles for Par-4 are being reported.
Anees Rahman Cheratta, Faisal Thayyullathil, Siraj Pallichankandy, Karthikeyan Subburayan, Ameer Alakkal, Sehamuddin Galadari   +5 more
doaj   +1 more source

In Vitro Veritas: From 2D Cultures to Organ-on-a-Chip Models to Study Immunogenic Cell Death in the Tumor Microenvironment

Cells, 2022
Immunogenic cell death (ICD) is a functionally unique form of cell death that promotes a T-cell-dependent anti-tumor immune response specific to antigens originating from dying cancer cells.
Dmitri V. Krysko, Robin Demuynck, Iuliia Efimova, Faye Naessens, Olga Krysko, Elena Catanzaro   +5 more
doaj   +1 more source

Antioxidants Threaten Multikinase Inhibitor Efficacy against Liver Cancer by Blocking Mitochondrial Reactive Oxygen Species

Antioxidants, 2021
Sorafenib and regorafenib, multikinase inhibitors (MKIs) used as standard chemotherapeutic agents for hepatocellular carcinoma (HCC), generate reactive oxygen species (ROS) during cancer treatment.
Blanca Cucarull, Anna Tutusaus, Tania Hernáez-Alsina, Pablo García de Frutos, María Reig, Anna Colell, Montserrat Marí, Albert Morales   +7 more
doaj   +1 more source

Caspase-8 deficiency induces a switch from TLR3 induced apoptosis to lysosomal cell death in neuroblastoma

Scientific Reports, 2021
In cancer cells only, TLR3 acquires death receptor properties by efficiently triggering the extrinsic pathway of apoptosis with Caspase-8 as apical protease.
Marie-Anaïs Locquet, Gabriel Ichim, Joseph Bisaccia, Aurelie Dutour, Serge Lebecque, Marie Castets, Kathrin Weber   +6 more
doaj   +1 more source