Molecular Oncology, EarlyView.CD226+CD8+ T cells express elevated levels of RUNX2, exhibit higher proliferation capacity, cytokines and cytolytic molecules expression, and migratory capacity. In contrast, CD226−CD8+ T cells display an exhausted phenotype associated with the increased expression of co‐inhibitory receptors and impaired effector functions.
Maryam Rezaeifar +4 more
wiley +1 more source
The logarithmic nature of thermal death time curves [PDF]
, 1921 W. D. Bigelow
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Molecular Oncology, EarlyView.Triacsin C inhibition of the acyl‐CoA synthetase long chain (ACSL) family decreases multiple myeloma cell survival, proliferation, mitochondrial respiration, and membrane potential. Made with Biorender.com. Multiple myeloma (MM) is an incurable cancer of plasma cells with a 5‐year survival rate of 59%.
Connor S. Murphy +12 more
wiley +1 more source
Coupling between death spikes and birth troughs. Part 2: Comparative analysis of salient features [PDF]
arXiv, 2018 In part 1 we identified a new coupling between death spikes and birth dips that occurs following catastrophic events such as influenza pandemics and earthquakes. Here we seek to characterize some of the key features. We introduce a transfer function defined as the amplitude of the birth trough (the output) divided by the amplitude of the death spike ...
arxiv
Lung Cancer Death Rates among Non-Smokers and Pipe and Cigarette Smokers [PDF]
, 1955 Percy Stocks, J. M. Campbell
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Molecular Oncology, EarlyView.Transient receptor potential melastatin‐4 (TRPM4) is overexpressed in prostate cancer (PCa). Knockout of TRPM4 resulted in reduced PCa tumor spheroid size and decreased PCa tumor spheroid outgrowth. In addition, lack of TRPM4 increased cell death in PCa tumor spheroids.
Florian Bochen +6 more
wiley +1 more source
Cell‐free DNA aneuploidy score as a dynamic early response marker in prostate cancer
Molecular Oncology, EarlyView.mFast‐SeqS‐based genome‐wide aneuploidy scores are concordant with aneuploidy scores obtained by whole genome sequencing from tumor tissue and can predict response to ARSI treatment at baseline and, at an early time point, to ARSI and taxanes. This assay can be easily performed at low cost and requires little input of cfDNA. Cell‐free circulating tumor
Khrystany T. Isebia +17 more
wiley +1 more source
PTEN modulates EGFR late endocytic trafficking and degradation by dephosphorylating Rab7
Nature Communications, 2016 Rab7 is a critical GTPase for endosome maturation and it is implicated in the endocytic traffic of several receptors, including EGFR. In this study, the authors reveal the potential role of PTEN in the endocytic trafficking pathway of EGFR, which is ...
Swapnil Rohidas Shinde +1 more
doaj +1 more source
A Case in Which Acute Spasmodic Pain in the Left Lower Extremity Was Completely Relieved by Sub-Dural Division of the Posterior Roots of Certain Spinal Nerves, All other Treatment Having Proved Useless. Death from Sudden Collapse and Cerebral Hæmorrhage on the Twelfth Dat after the Operation, at the Commencement of Apparent Convalescence [PDF]
, 1889 William H. Bennett
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