Results 101 to 110 of about 4,987,614 (290)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Reappraising Death

, 1982
This is the first in a series of nine articles by Pallis, a British neurologist, who maintains that it is legitimate to equate brain death with death, that the necessary and sufficient component of brain death is death of the brain stem, and that a dead ...
Pallis, Christopher
core   +1 more source

‘Early planning makes for a good death’: residential aged care nurses’ views on caring for those in the last months of life

BMC Nursing
Background The residential aged care (RAC) sector provides care to a significant number of older people across frail and vulnerable years, all the way through to death.
Priyanka Vandersman, Jennifer Tieman
doaj   +1 more source

Emerging mechanisms of lipid peroxidation in regulated cell death and its physiological implications

Cell Death and Disease
Regulated cell death (RCD) refers to the form of cell death that can be regulated by various biomacromolecules. Each cell death modalities have their distinct morphological changes and molecular mechanisms.
Yongxin Zheng, Junlu Sun, Zhi Luo, Yi-Min Li, Yong-Bo Huang   +4 more
semanticscholar   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

BECLIN-1/BECN1 at the barrier: a gatekeeper of epithelial and endothelial homeostasis

Autophagy Reports
Epithelial and endothelial barriers are essential for tissue homeostasis, protecting the body from environmental insults while regulating selective transport. The integrity of these barriers relies on dynamic intercellular junctions whose composition and
Juliani Juliani, Walter D. Fairlie, Erinna F. Lee   +2 more
doaj   +1 more source

LUBAC-Recruited CYLD and A20 Regulate Gene Activation and Cell Death by Exerting Opposing Effects on Linear Ubiquitin in Signaling Complexes

Cell Reports, 2015
Ubiquitination and deubiquitination are crucial for assembly and disassembly of signaling complexes. LUBAC-generated linear (M1) ubiquitin is important for signaling via various immune receptors.
Peter Draber, Sebastian Kupka, Matthias Reichert, Helena Draberova, Elodie Lafont, Diego de Miguel, Lisanne Spilgies, Silvia Surinova, Lucia Taraborrelli, Torsten Hartwig, Eva Rieser, Luigi Martino, Katrin Rittinger, Henning Walczak   +13 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Sudden, unexplained infant death investigation : a guide for the scene investigator [PDF]

This curriculum guide was created to improve teaching and evaluation techniques in the death investigator education and training programs. It provides instructional outlines and references to assist the instructor in the educational program.

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