Results 131 to 140 of about 4,987,614 (290)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
National Violent Death Reporting System: Web Coding Manual: Version 5.1 [PDF]
Version 5.1, revision date: 6/30/2015The NVDRS Coding Manual is a reference document to be used for defining cases, entering data, and checking data once they are entered.
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Epigenetic Rewiring of Protein Kinase Signalling in T-Cell Acute Lymphoblastic Leukaemia
Kinases and PhosphatasesT-cell acute lymphoblastic leukaemia (T-ALL) is an aggressive neoplastic malignancy characterised by the accumulation of multiple oncogenic and epigenetic alterations in haematopoietic T-cell precursors leading to their uncontrolled proliferation and ...
Claudina A. Pérez-Novo +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Infant death investigation : guidelines for the scene investigator [PDF]
The Guidelines for the Scene Investigator is a 39-page, 5x7 informational handbook that guides investigators in conducting an infant death investigation using recommended practices.
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Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease.
Cell, 2017 B. Stockwell +26 more
semanticscholar +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Potentiality, Irreversibility, and Death
, 2005 There has been growing concern about whether individuals who satisfy neurological criteria for death or who become non-heart- beating organ donors are really dead. This concern has focused on the issue of the potential for recovery that these individuals
Lizza, John P.
core +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
, 1993 To gain a better way of thinking about medical technology and our human mortality, we should begin backward. Death should be seen as the necessary and inevitable end point of medical care....We as a society remain uncertain about the status of patients ...
Callahan, Daniel
core +1 more source