Results 141 to 150 of about 10,693,133 (406)

Epigenetic Rewiring of Protein Kinase Signalling in T-Cell Acute Lymphoblastic Leukaemia

Kinases and Phosphatases
T-cell acute lymphoblastic leukaemia (T-ALL) is an aggressive neoplastic malignancy characterised by the accumulation of multiple oncogenic and epigenetic alterations in haematopoietic T-cell precursors leading to their uncontrolled proliferation and ...
Claudina A. Pérez-Novo, Amber Driesen, Maaike Van Trimpont, Claudia Theys, Emilie Logie, Pieter Van Vlierberghe, Wim Vanden Berghe   +6 more
doaj   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

European Code Against Cancer, 5th edition – hormone replacement therapy, other common medical therapies and cancer

Molecular Oncology, EarlyView.
The 5th edition of the European Code Against Cancer (ECAC5) contains 14 recommendations on cancer prevention. Here, we update the cancer prevention recommendations regarding the use of hormone replacement therapy (HRT), which is positioned as recommendation number 13 of the ECAC5.
Mangesh A. Thorat, Marc Arbyn, David Baldwin, Xavier Castells, Solveig Hofvind, Urska Ivanus, Carlo Senore, Esther Toes‐Zoutendijk, Carlijn van der Aalst, Carlos Canelo‐Aybar, Fiorella Karina Fernández‐Sáenz, Ariadna Feliu, Hajo Zeeb, Andre L. Carvalho, Erica D'Souza, David Ritchie, Carolina Espina, Iris Lansdorp‐Vogelaar, Andrea DeCensi   +18 more
wiley   +1 more source

Don't Fear the Reaper: An Epicurean Answer to Puzzles about Death and Injustice [PDF]

, 2007
I begin by sketching the Epicurean position on death - that it cannot be bad for the one who dies because she no longer exists - which has struck many people as specious. However, alternative views must specify who is wronged
Cushing, Simon
core  

Praying until death: revisiting three delays model to contextualize the socio-cultural factors associated with maternal deaths in a region with high prevalence of eclampsia in India [PDF]

, 2019
Md Illias Kanchan Sk, Balram Paswan, Ankit Anand, Nasim Ahamed Mondal   +3 more
openalex   +1 more source

Immunogenic cell death-related risk signature predicts prognosis and characterizes the tumour microenvironment in lower-grade glioma

, 2022
Jiayang Cai, Yuanyuan Hu, Zhang Ye, Liguo Ye, Lun Gao, Yixuan Wang, Qian Sun, Shiao Tong, Jian Yang, Qianxue Chen   +9 more
openalex   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease

Cell, 2017
B. Stockwell, J. Angeli, H. Bayır, A. Bush, M. Conrad, S. Dixon, S. Fulda, S. Gascón, Stavroula K. Hatzios, V. Kagan, Kay Noel, Xuejun Jiang, A. Linkermann, M. Murphy, M. Overholtzer, Atsushi Oyagi, G. Pagnussat, Jason Park, Qitao Ran, C. Rosenfeld, K. Salnikow, Daolin Tang, Daolin Tang, F. Torti, S. Torti, S. Toyokuni, K. Woerpel, Donna D. Zhang   +27 more
semanticscholar   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

The effect of weather on respiratory and cardiovascular deaths in 12 U.S. cities.

, 2002
Alfésio Luı́s Ferreira Braga, Antonella Zanobetti, Joel Schwartz   +2 more
openalex   +2 more sources