Results 41 to 50 of about 10,693,133 (406)

Death of a salesman [PDF]

, 2015
First paragraph: In December 2012 Australia became the first jurisdiction to mandate plain (or standardised) packaging for tobacco products. Many governments have been looking on with interest, anxious to learn if this is also the next step forward in ...
Hastings, Gerard B., Moodie, Crawford
core   +2 more sources

Long-range enhancement of N501Y-endowed mouse infectivity of SARS-CoV-2 by the non-RBD mutations of Ins215KLRS and H655Y

Biology Direct, 2022
Background Rodents, such as mice, are vulnerable targets, and potential intermediate hosts, of SARS-CoV-2 variants of concern, including Alpha, Beta, Gamma, and Omicron.
Yichao Zhu, Wenzhao Zhou, Zubiao Niu, Jiayi Sun, Zhengrong Zhang, Qinqin Li, You Zheng, Chenxi Wang, Lihua Gao, Qiang Sun   +9 more
doaj   +1 more source

SIRT1 inhibits mitochondrial hyperfusion associated mito-bulb formation to sensitize oral cancer cells for apoptosis in a mtROS-dependent signalling pathway

Cell Death and Disease, 2023
SIRT1 (NAD-dependent protein deacetylase sirtuin-1), a class III histone deacetylase acting as a tumor suppressor gene, is downregulated in oral cancer cells.
Srimanta Patra, Amruta Singh, Prakash P. Praharaj, Nitish K. Mohanta, Mrutyunjay Jena, Birija S. Patro, Ali Abusharha, Shankargouda Patil, Sujit K. Bhutia   +8 more
doaj   +1 more source

Evolution from a hinge actuator mechanism to an antenna deployment mechanism for use on the European large communications satellite (L-SAT/OLYMPUS) [PDF]

, 1984
The evolution of an Antenna Deployment Mechanism (ADM) from a Hinge Actuator Mechanism (HAM) is described as it pertains to the deployment of large satellite antennas.
Death, M. D.
core   +1 more source

Covid-19: risk factors for severe disease and death

British medical journal, 2020
A long list is emerging from largely unadjusted analyses, with age near the ...
R. Jordan, P. Adab, K. Cheng
semanticscholar   +1 more source

Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target

FEBS Letters, EarlyView.
This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz, Milagros Siebeck Caturelli, Lina S. Lehmann, Florian Kurth, Alexander G. Maier, Kai Matuschewski   +5 more
wiley   +1 more source

General practitioner strategies for managing patients with multimorbidity: a systematic review and thematic synthesis of qualitative research

BMC Family Practice, 2020
Background General practitioners (GPs) increasingly manage patients with multimorbidity but report challenges in doing so. Patients describe poor experiences with health care systems that treat each of their health conditions separately, resulting in ...
Raechel A. Damarell, Deidre D. Morgan, Jennifer J. Tieman   +2 more
doaj   +1 more source

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

FEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer, Matheus Felipe Santos, Maurício Mazzine Filho, Gabriela Oliveira Castro, Agustín Hernández, Manoel Aparecido Peres, Alejandro Miguel Katzin, Marcell Crispim   +7 more
wiley   +1 more source

Cell arrest and cell death in mammalian preimplantation development [PDF]

, 2011
The causes, modes, biological role and prospective significance of cell death in preimplantation development in humans and other mammals are still poorly understood.
A Bettegowda, A Bettegowda, A Bettegowda, A Jurisicova, AE Crosier, AS Jakobsen, C Robert, C Wrenzycki, D Fabian, DH Betts, E Memili, E Vanneste, Eckhard Wolf, Felix A. Habermann, FF Paula-Lopes, FJ Pomar, Fred Sinowatz, G Kroemer, GE Exley, GS Salvesen, H Badr, HM Knijn, Horst-Dieter Reichenbach, I Robertson, J Fujita, J Laurincik, J Wang, J Yuan, JE Dietrich, JO Gjorret, JO Gjorret, Joerg Gromoll, K Goossens, K Hardy, L Dubrez-Daloz, L Galluzzi, L Leibfried, L Vandaele, LA Pradelli, M Boelhauve, M Lamkanfi, Marc Boelhauve, ME Guicciardi, MG Diskin, Myriam Reichenbach, P Chomczynski, P Lonergan, PS Malhi, R Draker, R Sartori, S Bilodeau-Goeseels, S Cory, SA Bustin, Sandra Leidenfrost, TA Brevini, TJ Fan, Tuna Güngör, Y Gavrieli   +57 more
core   +8 more sources

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source