Results 101 to 110 of about 260,234 (339)

PM2.5 Induce Endothelial‐Mesenchymal Transition and Cardiac Fibrosis via the NCOA4‐Mediated Ferritinophagy

Advanced Science, EarlyView.
This study primarily reveals that PM2.5‐derived Fe‐containing particles, particularly magnetite, are specifically enriched in the heart. Here, they interact with NCOA4 in endothelial cells, disrupt iron homeostasis by enhancing ferritinophagy, and subsequently trigger the process of EndMT through the NCOA4/KLF5 pathway.
Qinglin Sun, Mengyuan Wang, Lin Liu, Ruiyang Ding, Kanglin Yan, Shiqian Liu, Xiaoke Ren, Qing Xu, Zhiwei Sun, Qian Liu, Yi Yang, Junchao Duan   +11 more
wiley   +1 more source

Discovery of a Baloxavir‐Inspired Endonuclease Inhibitor That Prevents Herpes Simplex Virus 1 Replication in Cell Culture and In Vivo

Advanced Science, EarlyView.
Current herpesvirus treatments targeting the viral DNA polymerase are limited by toxicities and drug resistance. Novel compounds inhibiting the nuclease activity of the herpes simplex virus 1 (HSV‐1) terminase complex, required for viral genome packaging, have been identified.
Sabina Andreu, Kai Tang, Jiahui Zhou, Gabriel Pino‐Peco, Nerea López‐Carrobles, Raquel Bello‐Morales, Daniel Galdo‐Torres, Lina Zhang, Federico Gago, José Antonio López‐Guerrero, Xinyong Liu, Peng Zhan, Luis Menéndez‐Arias   +12 more
wiley   +1 more source

Results and observations from the reconstruction of continuous time series of mortality by cause of death [PDF]

Though many countries have been collecting cause-of-death information from death certificates for more than a century, these valuable data sources remain underexplored.
Markéta Pechholdová
core  

Certification and registration of death-the urgent need for improvement [PDF]

, 1901
James Robert Kaye
openalex   +1 more source

Constructing Dual‐Atomic Fe─Fe Sites Nanozyme for Targeted Osteoarthritis Therapy through Mitigating Oxidative Stress and Cartilage Degeneration

Advanced Science, EarlyView.
A novel bimetallic nanozyme (Fe2–NCs) with well‐defined Fe–Fe active sites is synthesized through a host–guest coordination strategy, which exhibits an exceptional therapeutic efficacy in osteoarthritis therapy. Experimental and theoretical analyses uncover the intrinsic catalytic mechanism at the atomic level, offering fundamental insights and design ...
Ting Ying, Qi Wang, Dejian Li, Yao Wang, Pengfang Zhang, Chengqing Yi, Rui Zhu   +6 more
wiley   +1 more source

Interpretable Multimodal Fusion Model Enhances Postoperative Recurrence Prediction in Gastric Cancer

Advanced Science, EarlyView.
An interpretable multimodal fusion model (RSA) integrating clinical, radiomic, and pathomic features is developed and validated to predict early postoperative recurrence in gastric cancer. The RSA model demonstrates superior predictive performance and holds potential for guiding adjuvant chemotherapy decisions and improving individualized patient ...
Ping'an Ding, Jiaxuan Yang, Sheng Chen, Honghai Guo, Jiaxiang Wu, Haotian Wu, Li Yang, Wenqian Ma, Yuan Tian, Renjun Gu, Lilong Zhang, Ning Meng, Xiaolong Li, Zhenjiang Guo, Yueping Liu, Lingjiao Meng, Qun Zhao   +16 more
wiley   +1 more source

Evaluación de la calidad de los certificados de defunción del Hospital Amor de Patria, de San Andrés Islas, Colombia, en 2014

Revista Facultad Nacional de Salud Pública, 2018
Introduction: The quality of the medical death certificate in the ‘causes’ section is of fundamental importance in public health, in addition to its ethical, medico-legal and juridical consequences.
Carlos Andrés Montalvo-Arce, Yendi Shandira Kelly-Forbes   +1 more
doaj   +1 more source

Youth Gang Violence and Guns: Data Collection in California [PDF]

, 2009
Provides an overview of data on youth gang-related homicides, the role of firearms in the rising lethality of gang violence, and the state of data collection.
Josh Sugarmann, Tom Diaz
core  

Integrin αvβ6‐Targeted PET/CT Imaging of Non‐Small Cell Lung Cancer with [68Ga]Ga‐Trivehexin: Improved Preoperative Lymph Node Staging and Association with Immunohistochemistry

Advanced Science, EarlyView.
Integrin αvβ6‐targeted [68Ga]Ga‐Trivehexin positron emission tomography/computed tomography (PET/CT) can accurately identify regional lymph nodes and cerebral metastases in non‐small cell lung cancer (NSCLC) compared with 2‐deoxy‐2‐[18F]fluoro‐D‐glucose ([18F]FDG).
Huiqin Wu, Chongjiao Li, Ling Li, Yueli Tian, Zhiwei Xiao, Yiwei Huang, Juan Zhong, Jianying Huang, Qiongrong Chen, Yong He   +9 more
wiley   +1 more source

COVID-19 Death Determination Methods, Minnesota, USA, 2020–2022

Emerging Infectious Diseases
Accurate and timely mortality surveillance is crucial for elucidating risk factors, particularly for emerging diseases. We compared use of COVID-19 keywords on death certificates alone to identify COVID-19 deaths in Minnesota, USA, during 2020–2022 ...
Lydia J. Fess, Ashley Fell, Siobhan O’Toole, Paige D’Heilly, Stacy Holzbauer, Leslie Kollmann, Amanda Markelz, Keeley Morris, Abbey Ruhland, Scott Seys, Elizabeth Schiffman, Haley Wienkes, Zachary Zirnhelt, Stephanie Meyer, Kathryn Como-Sabetti   +14 more
doaj   +1 more source