Results 21 to 30 of about 5,657,584 (240)
Bi-specific molecule against EGFR and death receptors simultaneously targets proliferation and death pathways in tumors [PDF]
Scientific Reports, 2017 Developing therapeutics that target multiple receptor signaling pathways in tumors is critical as therapies targeting single specific biomarker/pathway have shown limited efficacy in patients with cancer.
Yanni Zhu +7 more
doaj +2 more sources
Death receptors as targets in cancer. [PDF]
Br J Pharmacol, 2013 Micheau O, Shirley S, Dufour F.
europepmc +2 more sources
Frontiers in Immunology, 2023 BackgroundTNF-related apoptosis-inducing ligand (TRAIL) is a member of the TNF superfamily that can either induce cell death or activate survival pathways after binding to death receptors (DRs) DR4 or DR5.
Sinem Gunalp +15 more
doaj +1 more source
Pharmaceutics, 2023 The TRAIL (TNF-related apoptosis-inducing ligand) apoptotic pathway is extensively exploited in the development of targeted antitumor therapy due to TRAIL specificity towards its cognate receptors, namely death receptors DR4 and DR5.
Anne V. Yagolovich +2 more
doaj +1 more source
TRAIL and its receptors in cardiac diseases
Frontiers in Physiology, 2023 Cardiovascular disease is a leading cause of death worldwide. Loss of cardiomyocytes that occurs during many types of damage to the heart such as ischemic injury and stress caused by pressure overload, diminishes cardiac function due to their limited ...
Laurel A. Grisanti
doaj +1 more source
Genistein Sensitizes Human Cholangiocarcinoma Cell Lines to Be Susceptible to Natural Killer Cells
Biology, 2022 Cholangiocarcinoma (CCA) is a lethal bile duct cancer, which has poor treatment outcomes due to its high resistance to chemotherapy and cancer recurrence.
Chutipa Chiawpanit +4 more
doaj +1 more source
Frontiers in Immunology, 2022 NK cells are key mediators of immune cell-mediated cytotoxicity toward infected and transformed cells, being one of the main executors of cell death in the immune system.
Ariel Ramírez-Labrada +24 more
doaj +1 more source
Volatile oil of Teucrium alopecurus sensitizes colon cancer cells to TRAIL-induced cell death
Frontiers in Bioscience-Scholar, 2021 TNF-related apoptosis-inducing ligand (TRAIL/Apo2L), a member of cytokine family, is known to selectively induce apoptosis in cancer cells. However, developing resistance to TRAIL is a major obstacle in cancer therapy.
Fatma Guesmi +7 more
doaj +1 more source
eLife, 2021 Colorectal cancer (CRC) remains a leading cause of cancer death, and its mortality is associated with metastasis and chemoresistance. We demonstrate that oxaliplatin-resistant CRC cells are sensitized to TRAIL-mediated apoptosis.
Joshua D Greenlee +6 more
doaj +1 more source
TRAF2 Controls Death Receptor-Induced Caspase-8 Processing and Facilitates Proinflammatory Signaling
Frontiers in Immunology, 2019 Tumor necrosis factor (TNF) receptor associated factor-2 (TRAF2) knockout (KO) cells were generated to investigate the role of TRAF2 in signaling by TNFR1 and the CD95-type death receptors (DRs) TRAILR1/2 and CD95.
Jennifer Kreckel +4 more
doaj +1 more source