Results 1 to 10 of about 991,539 (161)
Regulation of Cancer Metastasis by TRAIL/Death Receptor Signaling
Biomolecules, 2021 Death ligands such as tumor necrosis factor-related apoptosis-inducing ligand (TRAIL; TNFSF10) and their corresponding death receptors (e.g., DR5) not only initiate apoptosis through activation of the extrinsic apoptotic pathway but also exert non ...
You-Take Oh, Shi-Yong Sun
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Regulation of anoikis by extrinsic death receptor pathways [PDF]
Cell Communication and Signaling, 2023 Metastatic cancer cells can develop anoikis resistance in the absence of substrate attachment and survive to fight tumors. Anoikis is mediated by endogenous mitochondria-dependent and exogenous death receptor pathways, and studies have shown that caspase-
Ying-Hao Han +5 more
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Virus Infection and Death Receptor-Mediated Apoptosis
Viruses, 2017 Virus infection can trigger extrinsic apoptosis. Cell-surface death receptors of the tumor necrosis factor family mediate this process. They either assist persistent viral infection or elicit the elimination of infected cells by the host.
Xingchen Zhou +4 more
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Advances in the study of death receptor 5 [PDF]
Frontiers in PharmacologyDR5, a receptor with the highest affinity for TRAIL under physiological conditions, selectively induces apoptosis in specific target cells such as tumor and aberrant immune cells, while minimally affecting normal cells. The TRAIL-DR5 signaling pathway is
Xuan Qiao +9 more
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A bispecific anti-MUC16/anti-death receptor 5 antibody achieves effective and tumor-selective death receptor 5-mediated tumor regression [PDF]
Scientific ReportsThe bispecific antibody IMV-M was designed to selectively bind and cluster death receptor 5 (DR5) upon engaging the tumor antigen MUC16 through a novel mechanism—clustering multiple IMV-M molecules on a single MUC16 molecule.
Victor S. Goldmacher +3 more
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Cell Reports, 2021 Summary: Receptor clustering is the first and critical step to activate apoptosis by death receptor-5 (DR5). The recent discovery of the autoinhibitory DR5 ectodomain has challenged the long-standing view of its mechanistic activation by the natural ...
Gururaj Shivange +9 more
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Nradd Acts as a Negative Feedback Regulator of Wnt/β-Catenin Signaling and Promotes Apoptosis
Biomolecules, 2021 Wnt/β-catenin signaling controls many biological processes for the generation and sustainability of proper tissue size, organization and function during development and homeostasis.
Ozgun Ozalp +8 more
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AIDS and the death receptors [PDF]
British Medical Bulletin, 1997 Activation-induced cell death (AICD) of T cells involves the CD95 receptor/ligand system. T cell activation through the T cell receptor results in expression of the CD95 ligand (CD95L) that acts on CD95+ cells by direct binding and in a paracrine or autocrine fashion.
M E, Peter +3 more
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Death receptor signaling [PDF]
Journal of Cell Science, 2005 Apoptosis or programmed cell death is a common property of multicellular organisms ([Danial and Korsmeyer, 2004][1]; [Krammer, 2000][2]). It can be triggered by a number of factors, including UV- or γ-irradiation, chemotherapeutic drugs or signaling by death receptors (DR).
Inna, Lavrik +2 more
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microRNAs and death receptors [PDF]
Cytokine & Growth Factor Reviews, 2008 Death receptors induce apoptosis through either the Type I or II pathway. In Type I cells, the initiator caspase-8 directly activates effector caspases such as caspase-3, whereas in Type II cells, the death signal is amplified through mitochondria thereby activating effector caspases causing cell death. Recently, there have been advances in elucidating
Sun-Mi, Park, Marcus E, Peter
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