Results 1 to 10 of about 4,365,723 (297)

Regulation of Cancer Metastasis by TRAIL/Death Receptor Signaling

Biomolecules, 2021
Death ligands such as tumor necrosis factor-related apoptosis-inducing ligand (TRAIL; TNFSF10) and their corresponding death receptors (e.g., DR5) not only initiate apoptosis through activation of the extrinsic apoptotic pathway but also exert non ...
You-Take Oh, Shi-Yong Sun
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Regulation of anoikis by extrinsic death receptor pathways [PDF]

Cell Communication and Signaling, 2023
Metastatic cancer cells can develop anoikis resistance in the absence of substrate attachment and survive to fight tumors. Anoikis is mediated by endogenous mitochondria-dependent and exogenous death receptor pathways, and studies have shown that caspase-
Ying-Hao Han, Yuan Wang, Seung-Jae Lee, Mei-Hua Jin, Hu-Nan Sun, Taeho Kwon   +5 more
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Advances in the study of death receptor 5 [PDF]

Frontiers in Pharmacology
DR5, a receptor with the highest affinity for TRAIL under physiological conditions, selectively induces apoptosis in specific target cells such as tumor and aberrant immune cells, while minimally affecting normal cells. The TRAIL-DR5 signaling pathway is
Xuan Qiao, Xuan Qiao, Shuang Guo, Zhiyun Meng, Hui Gan, Zhuona Wu, Yunbo Sun, Shuchen Liu, Guifang Dou, Ruolan Gu   +9 more
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A bispecific anti-MUC16/anti-death receptor 5 antibody achieves effective and tumor-selective death receptor 5-mediated tumor regression [PDF]

Scientific Reports
The bispecific antibody IMV-M was designed to selectively bind and cluster death receptor 5 (DR5) upon engaging the tumor antigen MUC16 through a novel mechanism—clustering multiple IMV-M molecules on a single MUC16 molecule.
Victor S. Goldmacher, Iosif Gershteyn, Ravi Chari, Yelena Kovtun   +3 more
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A patch of positively charged residues regulates the efficacy of clinical DR5 antibodies in solid tumors

Cell Reports, 2021
Summary: Receptor clustering is the first and critical step to activate apoptosis by death receptor-5 (DR5). The recent discovery of the autoinhibitory DR5 ectodomain has challenged the long-standing view of its mechanistic activation by the natural ...
Gururaj Shivange, Tanmoy Mondal, Evan Lyerly, Sanchita Bhatnagar, Charles N. Landen, Shivani Reddy, Jonathan Kim, Britney Doan, Paula Riddle, Jogender Tushir-Singh   +9 more
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Nradd Acts as a Negative Feedback Regulator of Wnt/β-Catenin Signaling and Promotes Apoptosis

Biomolecules, 2021
Wnt/β-catenin signaling controls many biological processes for the generation and sustainability of proper tissue size, organization and function during development and homeostasis.
Ozgun Ozalp, Ozge Cark, Yagmur Azbazdar, Betul Haykir, Gokhan Cucun, Ismail Kucukaylak, Gozde Alkan-Yesilyurt, Erdinc Sezgin, Gunes Ozhan   +8 more
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Synergistic antitumor effects of circularly permuted TRAIL with doxorubicin in triple-negative breast cancer

Acta Biochimica et Biophysica Sinica, 2023
Circularly permuted TRAIL (CPT), a novel recombinant TRAIL mutant, is a potent antitumor agent. However, its efficacy in triple-negative breast cancer (TNBC) remains unclear.
Liu Jia, Zhu Tienian, Liu Jiankun, Cui Yujie, Yang Shifang, Zhao Ruijing   +5 more
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(20S) Ginsenoside Rh2-Activated, Distinct Apoptosis Pathways in Highly and Poorly Differentiated Human Esophageal Cancer Cells

Molecules, 2022
Ginsenoside Rh2 (G-Rh2), a rare ginsenoside isolated from red ginseng, has considerable anti-cancer activity and induces apoptosis in a variety of cancer cells, but its activity in esophageal cancer cells is unclear.
He Li, Chunxiao Han, Chen Chen, Guanghong Han, Yang Li   +4 more
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Induction of p53-Dependent Apoptosis by Prostaglandin A₂

Biomolecules, 2020
Prostaglandin (PG) A2, one of cyclopentenone PGs, is known to induce activation of apoptosis in various cancer cells. Although PGA2 has been reported to cause activation of apoptosis by altering the expression of apoptosis-related genes, the role of p53,
Su-Been Lee, Sangsun Lee, Ji-Young Park, Sun-Young Lee, Ho-Shik Kim   +4 more
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A Structural and Functional Perspective of Death Receptor 6

Frontiers in Pharmacology, 2022
As a member of the tumor necrosis factor receptor superfamily (TNFRSF), death receptor 6 (DR6) has a similar structural architecture to other family members.
Xiuying Ren, Zhi Lin, Wensu Yuan
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