Results 11 to 20 of about 991,638 (260)
Acta Biochimica et Biophysica Sinica, 2023 Circularly permuted TRAIL (CPT), a novel recombinant TRAIL mutant, is a potent antitumor agent. However, its efficacy in triple-negative breast cancer (TNBC) remains unclear.
Liu Jia +5 more
doaj +1 more source
Death receptor signals to the mitochondria [PDF]
Cancer Biology & Therapy, 2004 Apoptosis is the best-characterized form of programmed cell death (PCD) and is of fundamental importance in tissue homeostasis. In mammalian systems, there are two major pathways that are involved in the initiation of apoptosis: the "extrinsic" death receptor pathway and the "intrinsic" mitochondrial pathway.
Khosravi-Far, Roya, Esposti, Mauro Degli
openaire +2 more sources
Molecules, 2022 Ginsenoside Rh2 (G-Rh2), a rare ginsenoside isolated from red ginseng, has considerable anti-cancer activity and induces apoptosis in a variety of cancer cells, but its activity in esophageal cancer cells is unclear.
He Li +4 more
doaj +1 more source
Induction of p53-Dependent Apoptosis by Prostaglandin A2
Biomolecules, 2020 Prostaglandin (PG) A2, one of cyclopentenone PGs, is known to induce activation of apoptosis in various cancer cells. Although PGA2 has been reported to cause activation of apoptosis by altering the expression of apoptosis-related genes, the role of p53,
Su-Been Lee +4 more
doaj +1 more source
A Structural and Functional Perspective of Death Receptor 6
Frontiers in Pharmacology, 2022 As a member of the tumor necrosis factor receptor superfamily (TNFRSF), death receptor 6 (DR6) has a similar structural architecture to other family members.
Xiuying Ren, Zhi Lin, Wensu Yuan
doaj +1 more source
Tristetraprolin Posttranscriptionally Downregulates TRAIL Death Receptors
Cells, 2020 Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) has attracted attention as a potential candidate for cancer therapy. However, many primary cancers are resistant to TRAIL, even when combined with standard chemotherapy.
Won Hyeok Lee +8 more
doaj +1 more source
Life and death by death receptors
The FASEB Journal, 2009 ABSTRACT Death receptors are members of the tumor necrosis factor receptor superfamily characterized by a cytoplasmic region known as the “death domain” that enables the receptors to initiate cytotoxic signals when engaged by cognate ligands. Binding to the ligand results in receptor aggregation and recruitment of
Maria Eugenia, Guicciardi +1 more
openaire +3 more sources
An update on immunotherapy with PD-1 and PD-L1 blockade [PDF]
Yeungnam University Journal of Medicine, 2021 Cancer is the leading cause of death and is on the rise worldwide. Until 2010, the development of targeted treatment was mainly focused on the growth mechanisms of cancer.
Sung Ae Koh
doaj +1 more source
TRAIL/Apo-2L: Mechanisms and Clinical Applications in Cancer
Neoplasia: An International Journal for Oncology Research, 2001 TNF-related apoptosis-inducing ligand (TRAIL/APO2L) is a member of the TNF family that promotes apoptosis by binding to the transmembrane receptors TRAIL-R1 /DR4 and TRAIL-R2/DR5.
Rakesh K. Srivastava
doaj +1 more source
LUBAC prevents lethal dermatitis by inhibiting cell death induced by TNF, TRAIL and CD95L
Nature Communications, 2018 TNF mediated inflammation is critical in autoimmune mediated pathology, however many patients are refractory to current anti-TNF therapeutics. Here the authors show induction of several death ligands, in addition to TNF is sufficient to cause fatal ...
Lucia Taraborrelli +19 more
doaj +1 more source