GZ17-6.02 and Doxorubicin Interact to Kill Sarcoma Cells via Autophagy and Death Receptor Signaling
Frontiers in Oncology, 2020 GZ17-6.02 (602) is presently under phase I clinical evaluation (NCT03775525). We defined the mechanisms by which it interacted with a standard of care therapeutic doxorubicin to kill sarcoma cells.
Laurence Booth +3 more
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Identification and functional characterization of a mouse lymphotoxin beta-receptor like protein [PDF]
, 2005 Four different monoclonal rat anti mouse lymphotoxin beta-receptor (mLTbetaR) antibodies were generated in order to study the expression patterns and molecular mechanisms that follow the activation of this receptor which belongs to the TNFR superfamily ...
Seegers, Silvia
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The mutualistic fungus Piriformospora indica colonizes Arabidopsis roots by inducing an endoplasmic reticulum stress-triggered caspase-dependent cell death [PDF]
, 2012 In Arabidopsis thaliana roots, the mutualistic fungus Piriformospora indica initially colonizes living cells, which die as the colonization proceeds. We aimed to clarify the molecular basis of this colonization-associated cell death.
Zechmann, B. +4 more
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Apoptosis: Silencing the death receptors [PDF]
Current Biology, 1999 Spontaneous signaling from death-domain-containing receptors can result in inappropriate cell death. An inhibitory protein has recently been identified, called silencer of death domains (SODD), that binds to the death domain of tumor necrosis factor receptor 1, thereby negatively regulating downstream signaling.
Tschopp J, Martinon F, Hofmann K
openaire +3 more sources
Control of steroid receptor dynamics and function by genomic actions of the cochaperones p23 and Bag-1L [PDF]
, 2014 Molecular chaperones encompass a group of unrelated proteins that facilitate the correct assembly and disassembly of other macromolecular structures, which they themselves do not remain a part of.
Cato, L. +7 more
core +1 more source
Child Death, Near Death and Stillbirth Commission Annual Report for Calendar Year 2013
, 2015 2013 annual report of the Child Death, Near Death and Stillbirth ...
Child Death, Near Death and Stillbirth Commission
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Bistability in apoptosis by receptor clustering. [PDF]
PLoS Computational Biology, 2010 Apoptosis is a highly regulated cell death mechanism involved in many physiological processes. A key component of extrinsically activated apoptosis is the death receptor Fas which, on binding to its cognate ligand FasL, oligomerize to form the death ...
Kenneth L Ho, Heather A Harrington
doaj +1 more source
FAS (Fas cell surface death receptor) [PDF]
, 2015 CD95 (also known as Fas) is a death receptor that belongs to the TNF-receptor superfamily. Expressed at the cell surface as a homotrimer, this receptor implements both apoptotic and non-apoptotic signalling pathways.
Legembre, Patrick, Sanséau, Doriane
core +1 more source
Molecules, 2012 Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is considered as the most promising anticancer agent in the TNF superfamily because of its selective cytotoxicity against tumor cells versus normal primary cells.
Wojciech Krol +6 more
doaj +1 more source
FAS-dependent cell death in α-synuclein transgenic oligodendrocyte models of multiple system atrophy [PDF]
, 2013 Multiple system atrophy is a parkinsonian neurodegenerative disorder. It is cytopathologically characterized by accumulation of the protein p25α in cell bodies of oligodendrocytes followed by accumulation of aggregated α-synuclein in so-called glial ...
Christine L Kragh +52 more
core +2 more sources