Results 21 to 30 of about 991,638 (260)
A Mechanism for Death Receptor Discrimination by Death Adaptors [PDF]
Journal of Biological Chemistry, 2005 The death domain and death effector domain are two common motifs that mediate protein-protein interactions between components of cell death signaling complexes. The mechanism by which these domains engage their binding partners has been explored by extensive mutagenesis of two death adaptors, FADD and TRADD, suggesting that a death adaptor can ...
Cristinel, Sandu +4 more
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Mechanisms of Apoptosis in the Ovary
Scientific Papers Animal Science and Biotechnologies, 2023 Of ovarian follicular reserve, only a small part of these follicles reach maturity, most of them suffering an involution process called follicular atresia.
Liliana Petculescu-Ciochina +2 more
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Marine Drugs, 2022 Liver cancers, such as hepatocellular carcinoma (HCC), are a highly prevalent cause of cancer-related deaths. Current treatments to combat liver cancer are limited.
I-Ta Lu +7 more
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Overcoming TRAIL Resistance for Glioblastoma Treatment
Biomolecules, 2021 The tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) shows a promising therapeutic potential in cancer treatment as it exclusively causes apoptosis in a broad spectrum of cancer cells through triggering the extrinsic apoptosis ...
Longfei Deng +3 more
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Cells, 2013 Apoptotic cell death is coordinated through two distinct (type 1 and type 2) intracellular signaling pathways. How the type 1/type 2 choice is made remains a central problem in the biology of apoptosis and has implications for apoptosis related diseases ...
Somkanya C Raychaudhuri +1 more
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Dopamine receptor D2 regulates glioblastoma survival and death through MET and death receptor 4/5
Neoplasia: An International Journal for Oncology Research, 2023 Recent studies indicate that signaling molecules traditionally associated with central nervous system function play critical roles in cancer. Dopamine receptor signaling is implicated in various cancers including glioblastoma (GBM) and it is a recognized
Hye-Min Jeon +20 more
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Death receptors in chemotherapy and cancer [PDF]
Oncogene, 2004 Apoptosis, the cell's intrinsic death program, is a key regulator of tissue homeostasis. An imbalance between cell death and proliferation may result in tumor formation. Also, killing of cancer cells by cytotoxic therapies such as chemotherapy, gamma-irradiation or ligation of death receptors is predominantly mediated by triggering apoptosis in target ...
Klaus-Michael, Debatin, Peter H, Krammer
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Death Receptors and Their Ligands in Atherosclerosis [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2008 Atherosclerosis is characterized by the accumulation of a fibro-fatty plaque consisting of immune cells, vascular smooth muscle cells (VSMCs), vascular endothelial cells (ECs), and extracellular matrix, surrounding a lipid-rich core. The complexity of atherosclerosis is highlighted by the multifaceted effects that apoptosis and proliferation of ...
Mary M, Kavurma +2 more
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The Apoptosome: Heart and Soul of the Cell Death Machine
Neoplasia: An International Journal for Oncology Research, 1999 Apoptosis is a fundamental biologic process by which metazoan cells orchestrate their own self-demise. Genetic analyses of the nematode C elegans identified three core components of the suicide apparatus which include CED-3, CED-4, and CED-9.
Arul M. Chinnaiyan
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Frontiers in Cell and Developmental Biology, 2019 Due to its extensive vascularization and physiological function as a filter and storage organ, the liver is constantly exposed to infectious and tumorigenic threat, as well as damaging actions of xenobiotics.
Valentina Spinnenhirn +2 more
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