Results 31 to 40 of about 4,365,723 (297)

Dopamine receptor D2 regulates glioblastoma survival and death through MET and death receptor 4/5

Neoplasia: An International Journal for Oncology Research, 2023
Recent studies indicate that signaling molecules traditionally associated with central nervous system function play critical roles in cancer. Dopamine receptor signaling is implicated in various cancers including glioblastoma (GBM) and it is a recognized
Hye-Min Jeon, Young Taek Oh, Yong Jae Shin, Nakho Chang, Donggeun Kim, Donghun Woo, Yoon Yeup, Kyeung Min Joo, Heejin Jo, Heekyoung Yang, Jin-Ku Lee, Wonyoung Kang, Jason Sa, Won Jun Lee, James Hale, Justin D. Lathia, Benjamin Purow, Myung Jin Park, Jong Bae Park, Do-Hyun Nam, Jeongwu Lee   +20 more
doaj   +1 more source

Differential activation of JNK1 isoforms by TRAIL receptors modulate apoptosis of colon cancer cell lines [PDF]

, 2009
Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) induces apoptosis on binding to its receptors, death receptor 4 and 5 (DR4, DR5).
M Keane, Mehmet, H, A Samali, D Mahalingam, H Mehmet, Mahalingam, D, E Szegezdi, Szegezdi, E, Keane, M, G Pirianov, Pirianov, G, Samali, A   +11 more
core   +1 more source

Mapping the domains of CD134 as a functional receptor for feline immunodeficiency virus (FIV) [PDF]

, 2006
The feline homologue of CD134 (fCD134) is the primary binding receptor for feline immunodeficiency virus (FIV), targeting the virus preferentially to activated CD4+ helper T cells.
Bonci, F., Hosie, MJ, Bonci F, Willett BJ, Hosie MJ, Bonci, F, McMonagle, E.L., Hosie, M.J., Pistello, M, McMonagle EL, McMonagle, EL, Willett, B.J., Willett, BJ, PISTELLO, MAURO, Pistello, M.   +14 more
core   +1 more source

The Apoptosome: Heart and Soul of the Cell Death Machine

Neoplasia: An International Journal for Oncology Research, 1999
Apoptosis is a fundamental biologic process by which metazoan cells orchestrate their own self-demise. Genetic analyses of the nematode C elegans identified three core components of the suicide apparatus which include CED-3, CED-4, and CED-9.
Arul M. Chinnaiyan
doaj   +1 more source

Death Receptors and Their Ligands in Atherosclerosis [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2008
Atherosclerosis is characterized by the accumulation of a fibro-fatty plaque consisting of immune cells, vascular smooth muscle cells (VSMCs), vascular endothelial cells (ECs), and extracellular matrix, surrounding a lipid-rich core. The complexity of atherosclerosis is highlighted by the multifaceted effects that apoptosis and proliferation of ...
Mary M, Kavurma, Nicole Y, Tan, Martin R, Bennett   +2 more
openaire   +2 more sources

Death Receptor Interactions With the Mitochondrial Cell Death Pathway During Immune Cell-, Drug- and Toxin-Induced Liver Damage

Frontiers in Cell and Developmental Biology, 2019
Due to its extensive vascularization and physiological function as a filter and storage organ, the liver is constantly exposed to infectious and tumorigenic threat, as well as damaging actions of xenobiotics.
Valentina Spinnenhirn, Janine Demgenski, Thomas Brunner   +2 more
doaj   +1 more source

FAIM Is Regulated by MiR-206, MiR-1-3p and MiR-133b

Frontiers in Cell and Developmental Biology, 2020
Apoptosis plays an important role during development, control of tissue homeostasis and in pathological contexts. Apoptosis is executed mainly through the intrinsic pathway or the death receptor pathway, i.e., extrinsic pathway.
Elena Coccia, Elena Coccia, Elena Coccia, Marc Masanas, Joaquín López-Soriano, Joaquín López-Soriano, Joaquín López-Soriano, Miguel F. Segura, Joan X. Comella, Joan X. Comella, Joan X. Comella, M. José Pérez-García, M. José Pérez-García, M. José Pérez-García   +13 more
doaj   +1 more source

CD95 co-stimulation blocks activation of naive T cells by inhibiting T cell receptor signaling [PDF]

, 2009
CD95 is a multifunctional receptor that induces cell death or proliferation depending on the signal, cell type, and cellular context. Here, we describe a thus far unknown function of CD95 as a silencer of T cell activation.
Lindquist, Jonathan, Strauss, Gudrun, Lindquist, Jonathan A., Arhel, Nathalie, Nathalie Arhel, Tobias L. Haas, Edward Felder, Fulda, Simone, Haas, Tobias L., Henning Walczak, Felder, Edward, Kirchhoff, Frank, Gudrun Strauss, Sabine Karl, Simone Fulda, Walczak, Henning, Karl, Sabine, Frank Kirchhoff, Klaus-Michael Debatin, Debatin, Klaus-Michael, Jonathan A. Lindquist, Haas, Tobias   +21 more
core   +1 more source

Calcitonin receptor-like receptor is expressed on gastrointestinal immune cells [PDF]

, 2002
Background/Aims: Pharmacological and morphological studies suggest that the gut mucosal immune system and local neuropeptide-containing neurones interact.
Göke, B., Haberberger, R., Knauer, J., McGregor, G. P., Hagner, S., Voigt, K.   +5 more
core   +1 more source

Death receptors in chemotherapy and cancer [PDF]

Oncogene, 2004
Apoptosis, the cell's intrinsic death program, is a key regulator of tissue homeostasis. An imbalance between cell death and proliferation may result in tumor formation. Also, killing of cancer cells by cytotoxic therapies such as chemotherapy, gamma-irradiation or ligation of death receptors is predominantly mediated by triggering apoptosis in target ...
Klaus-Michael, Debatin, Peter H, Krammer
openaire   +2 more sources