Results 61 to 70 of about 2,794,922 (242)
P2X7 receptor: Death or life? [PDF]
Purinergic Signalling, 2005 The P2X(7) plasma membrane receptor is an intriguing molecule that is endowed with the ability to kill cells, as well as to activate many responses and even stimulate proliferation. Here, the authors give an overview on the multiplicity and complexity of P2X(7)-mediated responses, discussing recent information on this receptor. Particular attention has
ADINOLFI, Elena +6 more
openaire +2 more sources
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Numerous international studies have reported declines in new cancer diagnoses, delayed diagnoses and disruptions in cancer treatment following the implementation of COVID‐19 pandemic public health measures, raising concerns that these effects may ultimately contribute to increased cancer mortality.
Friederike Erdmann +8 more
wiley +1 more source
Potential Role of Tarantula Venom Peptides in Targeting Human Death Receptors: A Computational Study
Applied SciencesAnimal venom has been gaining traction as a potential source of therapeutics for various diseases. Spiders encompass a wide variety of venom-producing species, of which tarantulas of the family Theraphosidae are widely known across the globe.
Janus Isaiah R. Quiambao +2 more
doaj +1 more source
AMPA receptors are the major mediators of excitotoxic death in mature oligodendrocytes
Neurobiology of Disease, 2003 Myelination of axons is important for central nervous system function, but oligodendrocytes, which constitute CNS myelin, are vulnerable to excitotoxic injury and death.
Elizabeth A Leuchtmann +4 more
doaj +1 more source
Changes in expression of TNF alpha and its receptors mRNAs in oocytes and granulosa cells in mice with experimental immune ovarian failure [PDF]
, 2014 Purpose: To investigate the expression of TNF- α and its receptors (types I and II) at mRNA level in oocytes and granulose cells as well as to study effect of TNF-α on follicular cell death in mice with experimental immune ovarian failure induced by ...
Grushka, Nataliya +4 more
core +1 more source
Referral Patterns and Diagnostic Timeliness in Pediatric Cancer: A Hospital‐Based Study in Indonesia
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Timely diagnosis and treatment are critical for improving survival among children with cancer. In low‐ and middle‐income countries (LMICs), delays are common and may be influenced by fragmented referral pathways and diagnostic limitations.
Nur Melani Sari +5 more
wiley +1 more source
Regulation of anoikis by extrinsic death receptor pathways
Cell Communication and Signaling, 2023 Metastatic cancer cells can develop anoikis resistance in the absence of substrate attachment and survive to fight tumors. Anoikis is mediated by endogenous mitochondria-dependent and exogenous death receptor pathways, and studies have shown that caspase-
Ying-Hao Han +5 more
doaj +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Relapsed and/or refractory (R/R) pediatric acute leukemia carries a dismal prognosis, largely driven by chemoresistance to conventional salvage therapy. The BH3‐mimetic venetoclax, combined with chemotherapy or hypomethylating agents, has demonstrated efficacy in small clinical trials.
Katherine S. Colman +9 more
wiley +1 more source
Frontiers in Cellular Neuroscience, 2016 Cytoplasmic Ca2+ actively engages in diverse intracellular processes from protein synthesis, folding and trafficking to cell survival and death. Dysregulation of intracellular Ca2+ levels is observed in various neuropathological states including ...
Kyung Min eChung +4 more
doaj +1 more source
Role of p63 and p73 isoforms on the cell death in patients with hepatocellular carcinoma submitted to orthotopic liver transplantation. [PDF]
PLoS ONE, 2017 Patients with hepatocellular carcinoma (HCC) submitted to orthotopic liver transplantation (OLT) have a variable 5-year survival rate limited mostly by tumor recurrence.
Raúl González +13 more
doaj +1 more source