Results 101 to 110 of about 88,974,747 (261)

Structural brain preservation: a potential bridge to future medical technologies

Frontiers in Medical Technology
When faced with the prospect of death, some people would prefer a form of long-term preservation that may allow them to be restored to healthy life in the future, if technology ever develops to the point that this is feasible and humane.
Andrew T. McKenzie, Ariel Zeleznikow-Johnston, Ariel Zeleznikow-Johnston, Jordan S. Sparks, Oge Nnadi, John Smart, Keith Wiley, Michael A. Cerullo, Aschwin de Wolf, Francesca Minerva, Ramón Risco, George M. Church, George M. Church, João Pedro de Magalhães, João Pedro de Magalhães, Emil F. Kendziorra   +15 more
doaj   +1 more source

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

Molecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth, Rui P. L. Neves, Julia Geheb, Christian Ballmeyer, Nathalie Gaßmann, Kiki C. Andree, Monica Sudarsanam, Christiane Driemel, Celine Örencik, Andrè Franken, Eslam Elmaghraby, Sven H. Loosen, Roderburg Christoph, Sebastian Schoelch, Hans Neubauer, Wolfram T. Knoefel, Nikolas H. Stoecklein, Georg Fluegen   +17 more
wiley   +1 more source

Quantifying the duration and variability of thoracic organ procurement casesCentral MessagePerspective

JTCVS Open
Objective: To quantify and analyze key temporal intervals and variability in heart and lung thoracic organ procurement using multicenter registry data and assessing logistical complexity across operational phases and preservation modalities to inform ...
Pablo G. Sanchez, MD, PhD, Carson Herman, BSc, Kalyna Sconzert, BSc, Pratik Patel, MS, PhD, Alejandro Bribriesco, MD   +4 more
doaj   +1 more source

The C‐terminal region of KIF26B is indispensable for nephron progenitor condensation and kidney formation in mice

FEBS Open Bio, EarlyView.
KIF26B plays an important role in kidney development. We engineered mice lacking the C‐terminal region of KIF26B and found severe kidney defects, including bilateral renal agenesis, similar to full Kif26b knockout mice. The mutation disrupted nephron progenitor condensation and reduced Gdnf‐Wnt11 signaling, showing that the KIF26B C‐terminal region is ...
Yuta Yamamura, Kengo Furuichi, Hiromitsu Akamatsu, Naoki Yamamoto, Sako Keisuke, Akihiko Koshino, Taichiro Minami, Megumi Oshima, Akinori Hara, Norihiko Sakai, Miho Shimizu, Kenta Takahashi, Minako Yamamura, Shin‐ichi Horike, Takiko Daikoku, Kenichi Harada, Yohei Shinmyo, Hiroshi Kawasaki, Takashi Wada, Yasunori Iwata   +19 more
wiley   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Exploring Preservation Modalities in a Split Human Pancreas Model to Investigate the Effect on the Islet Isolation Outcomes

Transplantation Direct
Background. In islet transplantation, the use of dynamic hypothermic preservation techniques is a current challenge. This study compares the efficacy of 3 pancreas preservation methods: static cold storage, hypothermic machine perfusion (HMP), and ...
Antoine Buemi, MD, Nizar I. Mourad, PhD, Caroline Bouzin, PhD, Arnaud Devresse, MD, PhD, Delphine Hoton, MD, Aurelie Daumerie, Francis Zech, MD, PhD, Tom Darius, MD, PhD, Nada Kanaan, MD, Pierre Gianello, MD, PhD, Michel Mourad, MD, PhD   +10 more
doaj   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Utilization of Paragonix LIVERguard® donor organ transport system for static hypothermic preservation of a multivisceral allograft

Intestinal Failure
Background: Intestine transplants are highly sensitive to ischemia-reperfusion injury (IRI). Static cold storage (SCS) is the standard for multivisceral (MVT) allograft preservation but carries known risks.
Carolyn Smullin, Caitlin Thornley, Valeria Ripa, Brandon Pearson, Jonathan Jou, Robert S. Venick, Vatche Agopian, Fady Kaldas, Samer Ebaid, Douglas G. Farmer   +9 more
doaj   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

F-059IMPACT OF TIME INTERVAL BETWEEN DONOR BRAIN DEATH AND COLD PRESERVATION ON LONG-TERM OUTCOME IN LUNG TRANSPLANTATION [PDF]

Interactive CardioVascular and Thoracic Surgery, 2013
Yukio Tsushima, K. Slankamenac, S. Hillinger, D. Schneiter, P. Kestenholz, W. Weder, I. Inci   +6 more
openaire   +1 more source