Results 141 to 150 of about 1,117,135 (403)
Development of 4T1 breast cancer mouse model system for preclinical carbonic anhydrase IX studies
FEBS Open Bio, EarlyView.Carbonic anhydrase IX (CAIX) is a well‐recognised therapeutic target and prognostic biomarker in cancer. We developed and characterised a robust murine breast cancer model system that is suitable for CAIX studies in vitro and in vivo—it comprises both CAIX‐positive and CAIX‐negative controls and provides a solid platform for the comprehensive ...
Zane Kalniņa +13 more
wiley +1 more source
Debris-flow generated tsunamis and their dependence on debris-flow dynamics
Coastal Engineering, 2020 Debris-flow generated tsunamis can be extremely dangerous for lakeside settlements and infrastructure. Debris-flow composition strongly affects debris-flow thickness and velocity, and therefore also the generated tsunami. This interaction is, however, poorly understood.
de Lange, S. I. +4 more
openaire +3 more sources
CNS Mitochondria‐Derived Vesicle in Blood: Potential Biomarkers for Brain Mitochondria Dysfunction
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Mitochondrial dysfunction is a hallmark of neurodegenerative diseases like Alzheimer's (AD) and Parkinson's (PD). Our goal was to develop practical, noninvasive methods to assess mitochondrial status through the detection of mitochondria‐derived vesicles (MDVs).
Qi Liu +12 more
wiley +1 more source
The study of debris disks with SPICA [PDF]
, 2009 Debris disks are evidence that stars harbor reservoirs of dust-producing plantesimals on spatial scales similar the solar system. Debris disks present a wide range of sizes and structural features and there is growing evidence that, in some cases, they might be the result of the dynamical perturbations of a massive planet. Our solar system also harbors
arxiv +1 more source
Global Assessment of Supraglacial Debris‐Cover Extents
Geophysical Research Letters, 2018 Rocky debris on glacier surfaces influences ice melt rates and the response of glaciers to climate change. However, scarce data on the extent and evolution of supraglacial debris cover have so far limited its inclusion in regional to global glacier ...
D. Scherler, H. Wulf, N. Gorelick
semanticscholar +1 more source
A search for debris disks in the Herschel-ATLAS [PDF]
, 2010 Aims. We aim to demonstrate that the Herschel-ATLAS (H-ATLAS) is suitable for a blind and unbiased survey for debris disks by identifying candidate debris disks associated with main sequence stars in the initial science demonstration field of the survey.
Thompson, M. A., Vieiria, J.
core
β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations
Advanced Biology, Volume 9, Issue 3, March 2025.Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio +11 more
wiley +1 more source
The Formation of Pluto's Low Mass Satellites [PDF]
, 2013 Motivated by the New Horizons mission, we consider how Pluto's small satellites -- currently Styx, Nix, Kerberos, and Hydra -- grow in debris from the giant impact that forms the Pluto-Charon binary. After the impact, Pluto and Charon accrete some of the
Bromley, Benjamin C., Kenyon, Scott J.
core +1 more source
Debris-Influenced Sliding Laws and Basal Debris Balance [PDF]
Journal of Glaciology, 1986 AbstractIn order to determine the effect of basal debris drag as a component in a sliding law, it is necessary to know the basal debris concentration. Does, for example, this debris concentration exhibit uniformity, in an average sense, across a valley?
openaire +2 more sources
Current and Future Cornea Chip Models for Advancing Ophthalmic Research and Therapeutics
Advanced Biology, EarlyView.This review analyzes cornea chip technology as an innovative solution to corneal blindness and tissue scarcity. The examination encompasses recent developments in biomaterial design and fabrication methods replicating corneal architecture, highlighting applications in drug screening and disease modeling while addressing key challenges in mimicking ...
Minju Kim +3 more
wiley +1 more source