Results 51 to 60 of about 1,018,982 (351)

C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules

FEBS Letters, EarlyView.
Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican, Yara Nabawi, William Hongyu Zhang, Dunja Petrovic, Markus Wehrmann, Sara Muñoz‐García, Seda Koyuncu, David Vilchez   +7 more
wiley   +1 more source

A survey of debris trails from short-period comets

, 2007
We observed 34 comets using the 24 micron camera on the Spitzer Space Telescope. Each image contains the nucleus and covers at least 10^6 km of each comet's orbit. Debris trails due to mm-sized or larger particles were found along the orbits of 27 comets;
Kelley, Michael S., Reach, William T., Sykes, Mark V.   +2 more
core   +1 more source

An intracellular transporter mitigates the CO2‐induced decline in iron content in Arabidopsis shoots

FEBS Letters, EarlyView.
This study identifies a gene encoding a transmembrane protein, MIC, which contributes to the reduction of shoot Fe content observed in plants under elevated CO2. MIC is a putative Fe transporter localized to the Golgi and endosomal compartments. Its post‐translational regulation in roots may represent a potential target for improving plant nutrition ...
Timothy Mozzanino, Meijie Li, Cécile Fizames, Mattia Adamo, Laurence Lejay, Christian Dubos, Matthieu Platre, Antoine Martin   +7 more
wiley   +1 more source

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

Rise velocity of small polyolefin plastics in a seawater tank exposed to natural conditions in Hawai’i

Environmental Research Communications
Floating plastic is ubiquitous at the ocean surface, but the transport mechanisms associated with the type of particle and the effect of environmental parameters, including the presence of a biofilm on the polymers, are very limited.
Sarah-Jeanne Royer, Kayla C Brignac, Ferenc Ronkay, Kellie Teague, Granya Morris, Jennifer Lynch, Laurent Lebreton   +6 more
doaj   +1 more source

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

Molecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

STar-DETR: A Lightweight Real-Time Detection Transformer for Space Targets in Optical Sensor Systems

Sensors
Optical sensor systems are essential for space target detection. However, previous studies have prioritized detection accuracy over model efficiency, limiting their deployment on resource-constrained sensors.
Yao Xiao, Yang Guo, Qinghao Pang, Xu Yang, Zhengxu Zhao, Xianlong Yin   +5 more
doaj   +1 more source

Numerical simulation of debris flows triggered from the Strug rock fall source area, W Slovenia [PDF]

, 2006
The Strug landslide was triggered in December 2001 as a rockslide, followed by a rock fall. In 2002, about 20 debris flows were registered in the Kosec village; they were initiated in the Strug rock fall source area.
Fazarinc, Rok, Hojnik, Tomaž, Krzyk, Mario, Majes, Bojan, Mikoš, Matjaž, Rajar, Rudolf, Četina, Matjaž, Žagar, Dušan   +7 more
core   +1 more source

Direct Detection of Dark Matter Debris Flows

, 2012
Tidal stripping of dark matter from subhalos falling into the Milky Way produces narrow, cold tidal streams as well as more spatially extended "debris flows" in the form of shells, sheets, and plumes. Here we focus on the debris flow in the Via Lactea II
David N. Spergel, M. Boylan-Kolchin, Mariangela Lisanti, Michael Kuhlen, S. R. Majewski   +4 more
core   +1 more source

Coplanar circumbinary debris discs [PDF]

Monthly Notices of the Royal Astronomical Society, 2012
We present resolved Herschel images of circumbinary debris disks in the alpha CrB (HD139006) and beta Tri (HD13161) systems. We find that both disks are consistent with being aligned with the binary orbital planes. Though secular perturbations from the binary can align the disk, in both cases the alignment time at the distances at which the disk is ...
Kennedy, G. M.; Wyatt, M. C.; Sibthorpe, B.; Phillips, N. M.; Matthews, B. C.; Greaves, J. S.   +6 more
openaire   +5 more sources