Results 61 to 70 of about 400,556 (315)

Coplanar circumbinary debris discs [PDF]

Monthly Notices of the Royal Astronomical Society, 2012
We present resolved Herschel images of circumbinary debris disks in the alpha CrB (HD139006) and beta Tri (HD13161) systems. We find that both disks are consistent with being aligned with the binary orbital planes. Though secular perturbations from the binary can align the disk, in both cases the alignment time at the distances at which the disk is ...
Kennedy, G. M.; Wyatt, M. C.; Sibthorpe, B.; Phillips, N. M.; Matthews, B. C.; Greaves, J. S.   +6 more
openaire   +5 more sources

Integrative analysis of circulating tumor cells (CTCs) and exosomes from small‐cell lung cancer (SCLC) patients: a comprehensive approach

Molecular Oncology, EarlyView.
This study simultaneously investigated circulating tumor cells (CTCs) and exosomes from small‐cell lung cancer (SCLC) patients. The elevated expression of JUNB and CXCR4 in CTCs was a poor prognostic factor for SCLC patients, whereas exosomal overexpression of these biomarkers revealed a high discrimination ability of patients from healthy individuals,
Dimitrios Papakonstantinou, Argyro Roumeliotou, Evangelia Pantazaka, Athanasios‐Nasir Shaukat, Athina Christopoulou, Angelos Koutras, Foteinos‐Ioannis Dimitrakopoulos, Vassilis Georgoulias, Anastasia Xagara, Evangelia Chantzara, Fillipos Koinis, Athanasios Kotsakis, Constantinos Stathopoulos, Galatea Kallergi   +13 more
wiley   +1 more source

Hydrodynamic Ram Effect Caused by Debris Hypervelocity Impact on Satellite Tank

Applied Sciences, 2019
To study the hydrodynamic ram effect caused by the debris hypervelocity impact on the satellite tank, a numerical simulation of the spherical debris impacting the satellite tank at the velocity of 7000 m/s was carried out based on ANSYS/LS-DYNA software.
Beilei Zhao, Jiguang Zhao, Cunyan Cui, Yongsheng Duan   +3 more
doaj   +1 more source

Addressing persistent challenges in digital image analysis of cancer tissue: resources developed from a hackathon

Molecular Oncology, EarlyView.
Large multidimensional digital images of cancer tissue are becoming prolific, but many challenges exist to automatically extract relevant information from them using computational tools. We describe publicly available resources that have been developed jointly by expert and non‐expert computational biologists working together during a virtual hackathon
Sandhya Prabhakaran, Clarence Yapp, Gregory J. Baker, Johanna Beyer, Young Hwan Chang, Allison L. Creason, Robert Krueger, Jeremy Muhlich, Nathan Heath Patterson, Kevin Sidak, Damir Sudar, Adam J. Taylor, Luke Ternes, Jakob Troidl, Xie Yubin, Artem Sokolov, Darren R. Tyson   +16 more
wiley   +1 more source

Origin and abundance of beach debris in the Balearic Islands

Scientia Marina, 2007
The abundance, nature and possible sources of litter on 32 beaches on the Balearic Islands (Mediterranean Sea) were investigated in 2005. Mean summer abundances in the Balearics reached approximately 36 items m-1, with a corresponding weight of 32±25 g m-
Lorena Martinez-Ribes, Gotzon Basterretxea, Miquel Palmer, Joaquín Tintoré   +3 more
doaj   +1 more source

Respiratory complex I‐mediated NAD+ regeneration regulates cancer cell proliferation through the transcriptional and translational control of p21Cip1 expression by SIRT3 and SIRT7

Molecular Oncology, EarlyView.
NAD+ regeneration by mitochondrial complex I NADH dehydrogenase is important for cancer cell proliferation. Specifically, NAD+ is necessary for the activities of NAD+‐dependent deacetylases SIRT3 and SIRT7, which suppress the expression of p21Cip1 cyclin‐dependent kinase inhibitor, an antiproliferative molecule, at the translational and transcriptional
Masato Higurashi, Kazunori Mori, Hidetsugu Nakagawa, Momoko Uchida, Fumihiro Ishikawa, Motoko Shibanuma   +5 more
wiley   +1 more source

Local variability of a taiga snow cover due to vegetation and microtopography

Arctic, Antarctic, and Alpine Research, 2023
The taiga snow cover accumulates in relatively stable and windless weather. This should produce a uniform snow cover with continuous, laterally homogeneous stratigraphy and snow properties when the snow is deposited on a level, smooth substrate. However,
Anton Komarov, Matthew Sturm
doaj   +1 more source

Peripheral blood leukocyte signatures as biomarkers in relapsed ovarian cancer patients receiving combined anti‐CD73/anti‐PD‐L1 immunotherapy in arm A of the NSGO‐OV‐UMB1/ENGOT‐OV30 trial

Molecular Oncology, EarlyView.
Using mass cytometry, we analyzed serial blood samples from patients with relapsed epithelial ovarian cancer (EOC) treated with oleclumab–durvalumab combination immunotherapy in the NSGO‐OV‐UMB1/ENGOT‐OV30 trial. Our analysis identified potential predictive, monitoring, and response biomarkers detectable through liquid biopsy. These findings facilitate
Luka Tandaric, Annika Auranen, Katrin Kleinmanns, René DePont Christensen, Liv Cecilie Vestrheim Thomsen, Cara Ellen Wogsland, Emmet McCormack, Johanna Mäenpää, Kristine Madsen, Karen Stampe Petersson, Mansoor Raza Mirza, Line Bjørge   +11 more
wiley   +1 more source

Numerical Modelling Based on Digital Elevation Model (DEM) Analysis of Debris Flow at Rinjani Volcano, West Nusa Tenggara, Indonesia

Journal of the Civil Engineering Forum, 2021
Debris flow is a disaster occurring in cases where a sediment particle flows at high speed, down to the slope, and usually with high viscosity and speed. This disaster is very destructive and human life-threatening, especially in mountainous areas.
Muhammad Fatih Qodri, Noviardi Noviardi, Al Hussein Flowers Rizqi, Lindung Zalbuin Mase   +3 more
doaj   +1 more source

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source