Results 61 to 70 of about 1,047,819 (346)

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Separation of microplastics from deep-sea sediment using an affordable, simple to use, and easily accessible density separation device

Microplastics and Nanoplastics
Microplastics accumulate in the environment but methods to extract particles from sediment for quantification and identification often lack accuracy and reproducibility.
Katherine R. Shaw, Rachel Sandquist, Cameron Fairclough, Jesse Black, Alexandra Fitzgerald, Jaxson T. Shaw, Scott Gallager, Jennifer Lynch   +7 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

A Multi-Faceted Debris-Flood Hazard Assessment for Cougar Creek, Alberta, Canada

Hydrology, 2017
A destructive debris flood occurred between 19 and 21 June 2013 on Cougar Creek, located in Canmore, Alberta. Cougar Creek fan is likely the most densely developed alluvial fan in Canada.
Matthias Jakob, Hamish Weatherly, Stephanie Bale, Ashley Perkins, Brent MacDonald   +4 more
doaj   +1 more source

Numerical simulation of debris flows triggered from the Strug rock fall source area, W Slovenia [PDF]

, 2006
The Strug landslide was triggered in December 2001 as a rockslide, followed by a rock fall. In 2002, about 20 debris flows were registered in the Kosec village; they were initiated in the Strug rock fall source area.
Fazarinc, Rok, Hojnik, Tomaž, Krzyk, Mario, Majes, Bojan, Mikoš, Matjaž, Rajar, Rudolf, Četina, Matjaž, Žagar, Dušan   +7 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Bayesian Adaptive Extended Kalman-Based Orbit Determination for Optical Observation Satellites

Sensors
As the number of satellites and amount of space debris in Low-Earth orbit (LEO) increase, high-precision orbit determination is crucial for ensuring the safe operation of spacecraft and maintaining space situational awareness.
Yang Guo, Qinghao Pang, Xianlong Yin, Xueshu Shi, Zhengxu Zhao, Jian Sun, Jinsheng Wang   +6 more
doaj   +1 more source

Silica-Rich Bright Debris Disk around HD 15407A

, 2012
We report an intriguing debris disk towards the F3V star HD 15407A, in which an extremely large amount of warm fine dust (~ 10^(-7) M_Earth) is detected. The dust temperature is derived as ~ 500-600 K and the location of the debris dust is estimated as 0.
Bohren, Dorschner, Fabian, Fujiwara, Hammel, Holman, Houck, Ishiguro, Kemper, Kenyon, Koike, Lisse, Melis, Mikouchi, Murakami, Onaka, Oudmaijer, Rhee, Sargent, Takeda, van Leeuwen, Wyatt   +21 more
core   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Life cycle environmental assessment of marine debris and post-consumer waste plastics into asphalt pavements

Cleaner Environmental Systems
This study evaluates locally adapted recycling strategies for marine derelict fishing gear (DFG) and post-consumer waste (PCW) plastics in Hawaiʻi using a life cycle assessment (LCA) framework. Comparative cradle-to-gate LCAs were conducted to assess the
Mandy-Tanita Brinkmann, Cara Megill, Joep Meijer, Jennifer M. Lynch   +3 more
doaj   +1 more source