Results 61 to 70 of about 72,365 (283)

Reduced melt on debris-covered glaciers: investigations from Changri Nup Glacier, Nepal [PDF]

The Cryosphere, 2016
Approximately 25 % of the glacierized area in the Everest region is covered by debris, yet the surface mass balance of debris-covered portions of these glaciers has not been measured directly. In this study, ground-based measurements of surface elevation
C. Vincent, P. Wagnon, J. M. Shea, W. W. Immerzeel, P. Kraaijenbrink, D. Shrestha, A. Soruco, Y. Arnaud, F. Brun, E. Berthier, S. F. Sherpa   +10 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

HIGH-RESOLUTION MONITORING OF CURRENT RAPID TRANSFORMATIONS ON GLACIAL AND PERIGLACIAL ENVIRONMENTS [PDF]

The International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences, 2014
Glacial and periglacial environments are highly sensitive to climatic changes. Processes of cryosphere degradation may strongly impact human activities and infrastructures, and need to be monitored for improved understanding and for mitigation/adaptation.
L. Carturan, G. Blasone, S. Calligaro, A. Carton, F. Cazorzi, G. Dalla Fontana, D. Moro   +6 more
doaj   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Debris Emergence Elevations and Glacier Change

Frontiers in Earth Science, 2021
Debris-covered glaciers represent potentially significant stores of freshwater in river basins throughout High Mountain Asia (HMA). Direct glacier mass balance measurements are extremely difficult to maintain on debris-covered glaciers, and optical ...
Joseph M. Shea, Philip D. A. Kraaijenbrink, Walter W. Immerzeel, Fanny Brun   +3 more
doaj   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Reversed Surface-Mass-Balance Gradients on Himalayan Debris-Covered Glaciers Inferred from Remote Sensing

Remote Sensing, 2020
Meltwater from the glaciers in High Mountain Asia plays a critical role in water availability and food security in central and southern Asia. However, observations of glacier ablation and accumulation rates are limited in spatial and temporal scale due ...
Rosie R. Bisset, Amaury Dehecq, Daniel N. Goldberg, Matthias Huss, Robert G. Bingham, Noel Gourmelen   +5 more
doaj   +1 more source

Karl Popper and the Mechanisms of Hydrogen Embrittlement

Advanced Engineering Materials, EarlyView.
Representation of the beginning of loss of ductility rather than embrittlement. Small concentrations of hydrogen in a diffusible form within iron are well‐established to harm the mechanical integrity of steels. There are theories that attempt to explain the pernicious role of hydrogen.
H. K. D. H. Bhadeshia
wiley   +1 more source

Microstructure, Thermal Transport, and Dry‐Sliding Tribology of Powder‐Metallurgy Al7075 Composites Reinforced With Sol–Gel‐Derived ZnO–rGO Hybrid Nanoparticles

Advanced Engineering Materials, EarlyView.
Sol–gel‐derived ZnO–rGO hybrid nanoparticles enable Al7075 powder‐metallurgy composites to achieve concurrent gains in hardness and thermal conductivity while markedly lowering friction and wear. The hybrid architecture couples ZnO‐based load support with rGO‐assisted lamellar sliding and heat spreading, revealing a promising route toward lightweight ...
Bunyamin Aksakal, Cevher Kursat Macit, Merve Ayık, Hakan Tutumlu   +3 more
wiley   +1 more source

Observations on the development and decay processes of debris-flows [PDF]

, 2019
It is important to understand the development and decay processes of debris-flows in order to plan effective debris-flow countermeasures. However, few studies have successfully observed the development and decay processes of debris-flows.
Murasawa, Masaki, Imaizumi, Fumitoshi, Yokota, Yushi   +2 more
core   +1 more source