Results 181 to 190 of about 552,140 (371)

Microglial Rack1 Deficiency Alleviates Alzheimer's Disease Pathology through Enhancing IGF1‐Mediated Astrocytic Phagocytosis

Advanced Science, EarlyView.
Alzheimer's disease (AD) is the most common neurodegenerative disorder. This study demonstrates that microglial Rack1 deficiency decreased Aβ deposition and neuroinflammation and ameliorated cognitive impairments in AD model mice by enhancing IGF1‐mediated astrocytic phagocytosis.
Jingdan Zhang, Yanling He, Pin Yang, Hengchang Zhang, Yueyang Tong, Lingling Jiang, Zehan Li, Meichen Yan, Xiaoheng Li, Qinghu Yang, Jing Yang, Zengqiang Yuan, Jiyan Zhang, Jinbo Cheng   +13 more
wiley   +1 more source

Three-dimensional Simulations of the Magnetorotational Instability in Eccentric Disks

The Astrophysical Journal
Previously we demonstrated that the magnetorotational instability (MRI) grows vigorously in eccentric disks, much as it does in circular disks, and we investigated the nonlinear development of the eccentric MRI without vertical gravity.
Chi-Ho Chan, Tsvi Piran, Julian H. Krolik   +2 more
doaj   +1 more source

Acetylation Regulates ACSL4 Degradation Through Chaperone‐Mediated Autophagy to Alleviate Intervertebral Disc Degeneration

Advanced Science, EarlyView.
Intervertebral disc degeneration is triggered by ACSL4 accumulation‐mediated ferroptosis of nucleus pulposus cells due to CMA dysfunction. KAT2B promotes ACSL4 degradation via CMA through acetylation. AAV‐mediated LAMP2A delivery or engineered exosomes rescue nucleus pulposus cell senescence and disc degeneration.
Zhouwei Wu, Zhichen Jiang, Chenglong Hong, Shu Yang, Shuqing Jin, Chenyu Wu, Kaijie Guo, Jiang Liu, Shaobo Xu, Chenggui Wang, Xiangyang Wang   +10 more
wiley   +1 more source

Argon in β Pictoris–Entrapment and Release of Volatile in Disks

The Astrophysical Journal
Chemical compositions of planets reveal much about their formation environments. Such information is well sought-after in studies of solar system bodies and extrasolar ones.
Yanqin Wu, Kadin Worthen, Alexis Brandeker, Christine Chen   +3 more
doaj   +1 more source

The Nearby, Young, χ¹ Fornacis Cluster: Membership, Age, and an Extraordinary Ensemble of Dusty Debris Disks [PDF]

, 2019
B. Zuckerman, Beth Klein, Joel Kastner
openalex   +1 more source

Boron Nitride Nanomaterials Trigger Immunomodulatory Effects in Human Broncho‐Epithelial Cells by Modulating Eicosanoid Lipid Signaling

Advanced Science, EarlyView.
This study demonstrates that BNNT exposure disrupts lipid homeostasis in bronchial epithelial cell cultures and activates eicosanoid lipid biosynthesis, producing inflammatory lipid mediators like leukotrienes. These effects are more pronounced in asthmatic cell cultures compared to healthy ones.
Govind Gupta, Jonas Bossart, Sènan Mickael D'Almeida, Luis Augusto Visani de Luna, Christoph Schwärzler, Tingting Fu, Vanesa Ayala‐Nunez, Alexander Gogos, Marija Buljan, Vera M Kissling, Emmanuel Flahaut, Miguel Garcia, Cyrill Bussy, Peter Wick, Tina Buerki‐Thurnherr   +14 more
wiley   +1 more source

Vertical Structure of Gas and Dust in Four Debris Disks

The Astrophysical Journal
We present high-spectral-resolution M -band spectra from iSHELL on NASA’s Infrared Telescope Facility along the line of sight to the debris disk host star HD 32297. We also present a Gemini Planet Imager H -band polarimetric image of the HD 131488 debris
Kadin Worthen, Christine H. Chen, Sean D. Brittain, Cicero X. Lu, Isabel Rebollido, Aoife Brennan, Luca Matrà, Carl Melis, Timoteo Delgado, Aki Roberge, Johan Mazoyer   +10 more
doaj   +1 more source

High‐throughput exosomes analysis for ovarian cancer screening based on a double‐positive surface marker detection biochip

BMEMat, EarlyView.
A double‐positive surface marker detection approach was developed to conduct exosome surface protein detection in serum samples. It reaches single‐exosome detection, and over 300 exosome protein parameters are analyzed. The diagnostic accuracy achieved 90% in differentiation of high‐grade serous/serous ovarian carcinoma patients, benign patients, and ...
Jiaoyan Qiu, Yu Wu, Yihe Wang, Chao Wang, Soo‐Yeon Cho, Hui Huang, Yu Zhang, Lin Han   +7 more
wiley   +1 more source

Polarization of Circumstellar Debris Disk Light Echoes

The Astronomical Journal
Light echoes of debris disks around active stars can reveal disk structure and composition even when disks are not spatially resolved. Unfortunately, distinguishing reflected light from quiescent starlight and unexpected post-peak flare structure is ...
Austin J. King, Benjamin C. Bromley, Preston W. Harris, Scott J. Kenyon   +3 more
doaj   +1 more source

A COMPREHENSIVE DUST MODEL APPLIED TO THE RESOLVED BETA PICTORIS DEBRIS DISK FROM OPTICAL TO RADIO WAVELENGTHS [PDF]

, 2016
Nicholas P. Ballering, Kate Y.-L. Su, George H. Rieke, Andras Gaspar, Nicholas P. Ballering, Kate Y.-L. Su, George H. Rieke, Andras Gaspar   +7 more
openalex   +1 more source