Results 31 to 40 of about 187,375 (261)
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Engineering Planning Method and Control Modes for Debris Flow Disasters in Scenic Areas
Frontiers in Earth Science, 2021 Compared with debris flows in other areas, debris flows in scenic areas not only seriously threaten residents, tourists, roads, walkways, and other infrastructure, but also cause considerable damage to the landscapes and ecosystems of these areas ...
Xing-Long Gong +9 more
doaj +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Frontiers in Earth ScienceDebris flow is a prevalent geological disaster in Beijing, particularly in the Mentougou District, situated in the mountainous southwestern region of Beijing City. The past irrational exploitation of minerals has led to a substantial accumulation of slag,
Yongchao Li +22 more
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Experimental study on the impact of wide graded debris flow on check dam in high altitude area
Shuiwen dizhi gongcheng dizhiThe impact force of debris flow is the main cause of damage and destruction of check dam. In high altitude area, due to high mountains and deep valleys, serious physical weathering of surface materials, a wide range of source materials gradation, high ...
Shengqing HE, Da ZHENG, Wen ZHANG
doaj +1 more source
An Assessment Method for Debris Flow Dam Formation in Taiwan
Earth Sciences Research Journal, 2018 Debris flows in tributaries rush into and block the main branches of rivers and often result in serious hazards. Dam failures cause large floods in the downstream area and can lead to fatalities and property damage.
Kun-Ting Chen +5 more
doaj +1 more source