Results 41 to 50 of about 5,550,692 (265)

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Debris-flow monitoring and warning: Review and examples

Earth-Science Reviews, 2019
Debris flows represent one of the most dangerous types of mass movements, because of their high velocities, large impact forces and long runout distances.
M. Hürlimann, V. Coviello, C. Bel, Xiao-Jun Guo, M. Berti, C. Graf, J. Hübl, S. Miyata, Joel B. Smith, Hsiao-Yuan Yin   +9 more
semanticscholar   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

The recurrence interval of post-fire debris-flow generating rainfall in the southwestern United States

Geomorphology, 2020
In the southwestern United States, post-fire debris flows commonly initiate during short bursts of intense rainfall. To date, the frequency of the rainfall rates has not been quantified.
D. Staley, J. Kean, F. Rengers
semanticscholar   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Analysis of debris flow engineering treatment effect based on DEM data preprocessing in small watershed: A case study of Fangjiagou debris flow, Zhangxian County

Shuiwen dizhi gongcheng dizhi
After the Minxian-Zhangxian magnitude 6.6 earthquake on July 22, 2013, debris flow occurred in Fangjiagou, Zhangxian County. To reduce the potential damage of debris flow, a three-level check dam and drainage channel were built in the gully to regulate ...
Jingkai QU, Weimin YANG, Junfeng SHEN, Chunshan ZHANG, Feipeng WAN, Siqi MA, Chuancheng XU, Haibing TANG   +7 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Inundation, flow dynamics, and damage in the 9 January 2018 Montecito debris-flow event, California, USA: Opportunities and challenges for post-wildfire risk assessment

Geosphere, 2019
Shortly before the beginning of the 2017–2018 winter rainy season, one of the largest fires in California (USA) history (Thomas fire) substantially increased the susceptibility of steep slopes in Santa Barbara and Ventura Counties to debris flows. On 9
J. Kean, D. Staley, J. Lancaster, F. Rengers, B. Swanson, J. Coe, Janis L. Hernandez, Aaron Sigman, K. Allstadt, D. Lindsay   +9 more
semanticscholar   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Characteristics, Dynamic Analyses and Hazard Assessment of Debris Flows in Niumiangou Valley of Wenchuan County

Applied Sciences, 2023
Niumiangou valley, the epicenter of the 12 May 2008 Wenchuan earthquake (MS 8.0), became an area with frequent and dense debris flow disasters post-earthquake.
Zhiquan Yang, Xuguang Zhao, Mao Chen, Jie Zhang, Yi Yang, Wentao Chen, Xianfu Bai, Miaomiao Wang, Qi Wu   +8 more
doaj   +1 more source