Results 41 to 50 of about 187,375 (261)
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Assessment and Analysis of a Rainfall–Time-Lagging Water-Related Disaster in Mountainous Areas
Frontiers in Earth Science, 2021 Both global climate change and human activities are continuously impacting the abruptness and frequency of water-related natural disasters such as flash floods, debris flows, and landslides in mountainous areas, greatly threatening the safety of lives ...
Xu-Feng Yan +5 more
doaj +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
Research on debris flow initiation due to bed failure after Wenchuan earthquake
工程科学与技术, 2010 :In order to understand the initiation model and mechanism and forecast and prevent the debris flow after earthquake, designing the facilities of debris flow initiation according to the environment post-earthquake to study the debris flow initiation ...
zhuangjianqi
doaj
China Geology: Xinqiao Gully is located in the area of the 2008 Wenchuan Ms 8.0 earthquake in Sichuan province, China. Based on the investigation of the 2023 “6-26” Xinqiao Gully debris flow event, this study assessed the effectiveness of the debris flow control ...
Chang Yang +5 more
doaj +1 more source
Zhongguo dizhi zaihai yu fangzhi xuebao, 2022 Post-fire debris flow is a special torrent containing a large amount of loose material, which is closely related to forest fire. Its characteristics are significantly different from the conventional debris flow.
Xiangbin YANG +6 more
doaj +1 more source
MOVEMENT PATTERN OF DEBRIS FLOW
Italian Journal of Engineering Geology and Environment, 2011 link_to_subscribed_fulltext
Kang, AZC, Law, KT, Lee, CF, Chen, XQ
openaire +2 more sources
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source