Results 71 to 80 of about 1,196,152 (257)
Decadal Prediction of Marine Heatwaves in MPI‐ESM
Geophysical Research Letters, 2022 Marine Heatwaves (MHW) are SST extremes that can have devastating impacts on marine ecosystems and can influence circulation patterns in the ocean and the atmosphere.
Laura Hövel +2 more
doaj +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
The Decadal Climate Prediction Project (DCPP) contribution to CMIP6 [PDF]
Geoscientific Model Development, 2016 The Decadal Climate Prediction Project (DCPP) is a coordinated multi-model investigation into decadal climate prediction, predictability, and variability.
G. J. Boer +15 more
doaj +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
Decadal climate variability and cross-scale interactions: ICCL 2013 Expert Assessment Workshop
, 2014 The International Commission on Climate (ICCL), one of 10 international commissions of the International Association of Meteorology and Atmospheric Sciences (IAMAS) of the International Union of Geodesy and Geophysics (IUGG), held an Expert Assessment ...
Latif, Mojib +10 more
core +1 more source
FEBS Letters, EarlyView.Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise +5 more
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
A mechanism for decadal climate variability
, 1996 We describe in this paper a mechanism for decadal climate variability that can lead to decadal climate cycles in the North Pacific and North Atlantic Oceans. A hierarchy of numerical models and observations are used to understand the fundamental dynamics
Venzke, S. (Max-Planck-Institut fuer Meteorologie, Hamburg (Germany)) +6 more
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