Results 81 to 90 of about 1,196,152 (257)
New insights into the eastern subpolar North Atlantic meridional overturning circulation from OVIDE [PDF]
Ocean ScienceThe Atlantic Meridional Overturning Circulation (AMOC) is a key component of the Earth's climate. However, there are few long time series of observations of the AMOC, and the study of the mechanisms driving its variability depends mainly on numerical ...
H. Mercier +7 more
doaj +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Decadal variability of the subtropical gyre and deep meridional overturning circulation of the Indian Ocean [PDF]
, 2005 The work presented in this Thesis concerns the large-scale circulation of the Indian Ocean and follows three lines of investigation: (i) decadal variability of the subtropical gyre circulation; (ii) decadal variability of the deep meridional overturning ...
Palmer, M.D., Palmer, Matthew D
core +1 more source
Geophysical Research LettersUsing more than three decades (1993–2024) of satellite altimetry and ocean reanalysis, we reassess the dominant timescales of low‐frequency mesoscale eddy variability along the eastern boundary of the subtropical South Indian Ocean.
Yifei Zhou, Xuhua Cheng
doaj +1 more source
Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology
Molecular Oncology, EarlyView.This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic +15 more
wiley +1 more source
Decadal variability in seawater pH in the West Pacific: Evidence from coral delta B-11 records
, 2015 Long-term seawater pH records are essential for evaluating the rates of ocean acidification (OA) driven by anthropogenic emissions. Widespread, natural decadal variability in seawater pH superimposes on the long-term anthropogenic variations, likely ...
Ying Liu +17 more
core +1 more source
Variability of thermocline and intermediate waters in the South Atlantic
, 2011 This thesis investigates the variability of the intermediate and thermocline water mass properties in the South Atlantic, with a particular focus on salinity.
McCarthy, Gerard
core +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Variability of the Atlantic Meridional Overturning Circulation at 26N
, 2011 The Atlantic Meridional Overturning Circulation (AMOC) and its variability has received considerable attention, motivated by its major role in the global climate system.
Atkinson, Christopher Paul
core +1 more source
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source