Results 191 to 200 of about 3,732,492 (267)

A Novel Drug‐Loaded Porous Parylene Electrode for Targeted Anti‐Inflammatory Therapy and Hearing Preservation in Cochlear Implantation

Advanced Healthcare Materials, Volume 15, Issue 35, 18 September 2026.
A porous parylene‐coated electrode loaded with dexamethasone was developed to reduce inflammation after cochlear implantation. In guinea pigs, the device provided sustained drug release, maintained biocompatibility, improved auditory brainstem response thresholds, and reduced inflammatory cell infiltration and TNF‐α expression.
Chi‐Chieh Chang, Ying‐Chang Lu, Yu‐Ming Chang, Yen‐Hui Chan, Hong‐Yu Yan, Yi‐Shan Lee, Pei‐Hsuan Lin, Cheng‐Yu Hsieh, Chuan‐Jen Hsu, Tien‐Chen Liu, Hsien‐Yeh Chen, Chen‐Chi Wu   +11 more
wiley   +1 more source

Current progress of labeling strategies in tissue clearing for large-scale biological visualization. [PDF]

Front Cell Dev Biol
Wang SW, Wang YQ, Deng JW, Yang SB, Wang FY, Wu J, Liu JG.   +6 more
europepmc   +1 more source

A 3D Human Bone and Bone Marrow‐on‐a‐Chip Model for In Vitro Bone Remodeling and Immune Cell Maintenance

Advanced Science, Volume 13, Issue 51, 14 September 2026.
This study presents a human Bone (and Bone Marrow)‐on‐a‐Chip model based on native human bone scaffolds and autologous cells. Dynamic perfusion and sequential cell seeding replicate the physiological bone remodeling process in vitro, enabling the long‐term culture of functional, mature bone marrow immune subpopulations.
Nina Stelzer, Melanie‐Jasmin Ort, Kristian Händler, Emely Bortel, Ioanna Maria Dimitriou, Martin Textor, Georg N. Duda, Janosch Schoon, Uwe Marx, Uwe Kornak, Annika Winter, Bernhard Hesse, Stefanie Donner, Sebastian Hardt, Oliver Klein, Simon Reinke, Malte Spielmann, Sven Geißler   +17 more
wiley   +1 more source

Implementing David Procedure in Latin America: Closing the Gap with High-Income Countries. [PDF]

Braz J Cardiovasc Surg
Prieto G, Vanegas J, Guerrero J, Hurtado A, Licht M, Montes L.   +5 more
europepmc   +1 more source

Engineered Exosomal miR‐146a‐5p Reprograms BMSC Fate and Restores Mitochondrial Homeostasis in Glucocorticoid‐Induced Osteonecrosis of Femoral Head

Advanced Science, Volume 13, Issue 49, 3 September 2026.
Exosomal miR‐146a‐5p is identified as a pivotal regulator in steroid‐induced osteonecrosis. Its reduction activates NF‐κB signaling, compromises mitophagy, and disrupts mitochondrial bioenergetics, resulting in autophagic disequilibrium. Engineered exosomes delivering miR‐146a‐5p reinstate mitochondrial function, augment oxidative phosphorylation and ...
Zehui Lv, Xuejie Cai, Yiming Xu, Xingdong Yang, Ruoying Wang, Han Wang, Yixin Bian, Jiawei Xu, Jiao Lu, Lulu Liu, Yingjie Wang, Jibin Song, Bin Feng, Xisheng Weng   +13 more
wiley   +1 more source

Incidence and risk factors for permanent pacemaker implantation following aortic root surgery. [PDF]

Open Heart
Mani K, Naruka V, De Laurentis E, Abdellah M, Taylor E, Gallagher M, Morgan R, Jahangiri M.   +7 more
europepmc   +1 more source

Micro‐Galvanic Coupling Programs the Therapeutic Zinc Ion Window to Reconfigure Immune Cascades for Pro‐Regenerative Bone Healing

Advanced Science, Volume 13, Issue 50, 7 September 2026.
This study utilized alloy micro‐galvanic coupling design to regulate the release of essential elements, thereby programming immune responses and promoting regeneration. The sacrificial anodic process of Zn‐0.8Mg reduced Zn2+ release compared to the “large cathode‐small anode” coupling of Zn‐0.8Fe.
Chaoyang Sun, Bo Jia, Jiahui Shi, Shuang Li, Guo Bao, Dong Bian, Kai Chen, Junlong Tan, Xuenan Gu, Yan Guan, Yu Qin, Xinhua Qu, Xiaogang Wang, Yufeng Zheng, Hongtao Yang   +14 more
wiley   +1 more source

Comparative analysis of clearing methods for 3D imaging of the vasculature in mineralized mouse tissues. [PDF]

iScience
Ishola AO, Pillai A, Ahn T, RE-JOIN Consortium, Hsu CW, Lee B, Haelterman N, Wythe JD.   +7 more
europepmc   +1 more source

Targeting a Myeloid–Regulatory B Cell Network Reverses Immune Paralysis in Periprosthetic Joint Infections

Advanced Science, Volume 13, Issue 51, 14 September 2026.
Periprosthetic joint infection establishes a sophisticated immunosuppressive network between CXCR4+ PMN‐MDSCs and Bregs, inducing profound CD8+ T cell paralysis. Alendronate effectively disrupts this CXCR4+ PMN‐MDSC–Breg axis by targeting STAT3, thereby restoring local immune surveillance.
Jintao Wu, Shutao Zhang, Yumin Lin, Juyang Jiao, Zhiwei Fu, Qimin Hong, Ziyi Zhao, Xinhua Qu, Fei Su, Bing Yue   +9 more
wiley   +1 more source

RNA Sequencing Technologies in Acute Lymphoblastic Leukemia: A Comparative Technical Review. [PDF]

Curr Issues Mol Biol
Koutra M, Evangelidis P, Papalexandri A, Touloumenidou T, Hatzipantelis E, Sakellari I, Gavriilaki E, Tragiannidis A.   +7 more
europepmc   +1 more source