Results 41 to 50 of about 3,732,492 (267)

HMGCR‐Driven Cholesterol Metabolism Promotes Osteoarthritis Progression by Accelerating Synovial Fibroblast Senescence

Advanced Science, EarlyView.
In the pathological context of osteoarthritis (OA), the phosphorylation of AKT1 at Ser473 enhances its binding to Lys140 of Insig1, which facilitates the formation of AKT1–Insig1 complex. Subsequently, the activation of AKT1 promotes the phosphorylation of Insig1 at Ser189, potentially enhancing the dissociation of Insig1 from sterol regulatory element‑
Xiaoqi Zhang, Siru Zhou, Xi Liu, Wei Xiang, Xiuqin Peng, Yu Tian, Song Li, Hailin Wang, Bo Liao, Shunzheng Fang, Runze Jin, Jinhui Wu, Chuanqing Bai, Wei Zhang, Bo Huang, Bingfei Li, Lifeng Chen, Lin Chen, Bin Zhang, Zhenhong Ni   +19 more
wiley   +1 more source

USE OF TOOTH CLEARING TECHNIQUE TO DETERMINE ROOT AND CANAL MORPHOLOGY OF PERMANENT MANDIBULAR THIRD MOLARS IN POPULATION OF PESHAWAR: AN IN VITRO CROSS-SECTIONAL STUDY

Khyber Medical University Journal, 2021
OBJECTIVE: To find out number of roots, root-canals and canal configuration in permanent mandibular third molars through tooth clearing technique. METHODS: In this cross-sectional study, 193 extracted human mandibular permanent third molars with ...
Imran Khattak, Munawar Aziz Khattak, Yusra Jamil Khattak, Sana Arbab, Momena Rashid, Syed Amjad Shah   +5 more
doaj   +1 more source

Evaluation of techniques for human bone decalcification and amplification using sixteen STR markers

Egyptian Journal of Forensic Sciences, 2015
AbstractEfficient DNA extraction procedures, as well as accurate DNA amplification, are critical steps involved in the process of successful DNA analysis of skeletal samples. Unfortunately, at present there is no infallible method to recover DNA from highly degraded samples due to variations in DNA yield from larger bone fragments, which may be ...
Ajay Balayan, Abhilasha Kapoor, Garima Chaudhary, Anupuma Raina   +3 more
openaire   +2 more sources

Ubiquitination of ACSL4 by Parkin Suppresses Ferroptosis and Rescues Glucocorticoid‐Induced Bone Loss

Advanced Science, EarlyView.
GCs reduce Parkin, leading to ACSL4 accumulation and PUFA‐phospholipid‐driven ferroptosis in BMSCs, which impairs osteogenesis and promotes adipogenesis, causing GIOP. Parkin restoration (via OE‐Parkin or Parkin‐LNP@DSS6) ubiquitinates and degrades ACSL4, inhibiting ferroptosis, rescuing bone formation, and rescues GIOP bone loss.
Li‐jiang Han, Jian‐sen Miao, Yi‐feng Shi, Yi‐ting Tu, Yu‐zhe Lin, Lin‐Jie Chen, Bing‐hao Lin, Hua‐lin Li, Xuan‐qi Zheng, Hong‐qiang Wu, Hai‐xiao Liu, Lei Yang, Ai‐min Wu, Zhen Lin, Jian Xiao, Gang Zheng, Chen Jin   +16 more
wiley   +1 more source

Hypertonic saline- and detergent-accelerated EDTA-based decalcification better preserves mRNA of bones

Scientific Reports
Ethylenediaminetetraacetic acid (EDTA), a classically used chelating agent of decalcification, maintains good morphological details, but its slow decalcification limits its wider applications.
Zhongmin Li, Clara Wenhart, Andreas Reimann, Yi-Li Cho, Kristin Adler, Goetz Muench   +5 more
doaj   +1 more source

Na/K-ATPase Gene Expression in the Human Cochlea: A Study Using mRNA in situ Hybridization and Super-Resolution Structured Illumination Microscopy

Frontiers in Molecular Neuroscience, 2022
BackgroundThe pervasive Na/K-ATPase pump is highly expressed in the human cochlea and is involved in the generation of the endocochlear potential as well as auditory nerve signaling and relay.
Wei Liu, Helge Rask-Andersen
doaj   +1 more source

A Molten Salt Extraction Method for Palladium Recovery via the CaPd2 Intermetallic Compound

Advanced Science, EarlyView.
A designed Ca → CaPd2 → Pd pathway enables acid–free palladium recovery in molten salt. Calcium alloying forms anionic CaPd2, which is selectively oxidized by iodine from CaI2 to yield high–purity metallic Pd. ABSTRACT To address palladium scarcity and the low efficiency of conventional recovery processes, this work presents a molten–salt extraction ...
Jiapeng Zhang, Dengjie Yan, Muwen Chen, Baoqiang Xu, Bin Yang, Bingyi Song, Lingxin Kong   +6 more
wiley   +1 more source

Decalcification by perfusion. A new method for rapid softening of temporal bones [PDF]

, 1991
We describe a new technique, decalcification by perfusion, for the softening of bony tissue. The blood circulatory system was perfused in 16 rats via a cannula through the left heart ventricle with a fixative followed by New DecalcR (an acidic ...
Nilsson, Magnus, Albiin, Nils, Hellström, Sten   +2 more
core  

Decalcification: An Amenable Process in Oral Histology [PDF]

, 2021
In histopathology, decalcification of calcified tissues plays a highly essential role in determining any hard tissue pathology by means of adequate tissue processing protocols.
Nangia, Rajat, Dogra, Alisha, Kaur, Prabhpreet, Bhardwaj, Nandini, Puri, Abhiney   +4 more
core   +1 more source

The IRE1‐XBP1s Axis Drives Inflammatory Osteolysis by Regulating a 5‐HT Dependent Endogenous Anti‐Autophagy Mechanism

Advanced Science, EarlyView.
A previously unrecognized IRE1‐XBP1s‐Slc6a4 signaling axis links endoplasmic reticulum stress to serotonin metabolism, autophagy, and inflammatory osteoclastogenesis. By promoting intracellular serotonin uptake and reducing endogenous 3‐methyladenine accumulation, this pathway accelerates inflammatory bone destruction and provides a promising ...
Pengchao Yang, Binxiang Zhu, Yuzhi He, Yang Tian, Honglei Kang, Shian Hu, Pengju Wang, Yong Xu, Zhuowei Lei, Peijun Qi, Hao Yang, Yang Lin, Yimin Dong, Feng Li, Hanfeng Guan   +14 more
wiley   +1 more source