Results 71 to 80 of about 7,228 (241)

A Programmable Braided Silk‐Glass Fiber Ligament Promoting Rapid Motoric Recovery

Advanced Science, EarlyView.
A scalable three‐dimensional braiding strategy integrates silk and glass fibers into customizable artificial ligaments with programmable “J‐shaped” nonlinear mechanics. The silk‐rich architecture supports osseoligamentous integration, while glass fibers provide mechanical reinforcement and biomimetic mineralization cues, enabling strain‐adaptive load ...
Changbo Lu, Daming Liu, Haoxin Zhang, Zhiwei Qiao, Qiuming Gao, Jia Meng, Hongyin Yue, Songkai Li, Shuo Zhang, Tao Yuan, Yun Xue, Hui Jiang, Zhenguo Liu, Yibo Wang, Nirong Bao, Yuli Chen, Xiaojiang Yang   +16 more
wiley   +1 more source

Rational Surface Engineering Reduces Advanced Glycation End‐Product Adsorption and Improves Implant Integration

Advanced Science, EarlyView.
Targeted surface chemical modification prevents the accumulation of advanced glycation end products (AGEs) on implant surfaces, attenuates inflammation and fibrosis, effectively restores angiogenic activity, and improves osseointegration under diabetic conditions.
Thien Ngoc Le, Wenhao Chen, Tengxiao Huang, Tien Thanh Nguyen, Markos Negash Alemie, Xuan Duy Do, Giles Best, Jordan Li, Jitraporn Vongsvivut, Vi‐Khanh Truong, Weiwei Li, Yunpeng Zhao, Richard Bright, Krasimir Vasilev   +13 more
wiley   +1 more source

DUSP26 Regulated by YY1 Lactylation Couples Osteogenesis and Angiogenesis by Dephosphorylating PMPCB at Y141 and Activating Mitophagy in BMSCs

Advanced Science, EarlyView.
p300‐associated YY1 lactylation promotes DUSP26 expression in BMSCs. By regulating PMPCB phosphorylation and PINK1 processing, DUSP26 supports mitophagy, osteogenic differentiation, and pro‐angiogenic factor secretion. BMSC‐derived exosomes carrying a RUNX2 promoter‐driven DUSP26 plasmid favor osteogenic‐lineage transgene expression, partially ...
Yunpeng Lv, Feng Wu, Xiongjie Liang, Chong Liu, Wenhui Guo, Kejian Zhang, Jiawen Niu, Wenjie Jiang, Hongjian Xu, Anlong Jiang, Yang Zheng, Enming Yu, Xintao Wang, Jinglong Yan, Jingjun Xia, Chengchao Song   +15 more
wiley   +1 more source

Experiência clínica inicial na desmineralização química da valva aórtica: potencial aplicação como procedimento minimamente invasivo Chemical demineralization of the aortic valve: a potential application and preliminary clinical experience

Brazilian Journal of Cardiovascular Surgery, 2006
OBJETIVO: Utilização de nova tecnologia na desmineralização química da valva aórtica, em cirurgia cardíaca com circulação extracorpórea, avaliação de suas alterações hemodinâmicas e reportar eventos relacionados à técnica.
Ricardo Carvalho Lima, Gerhard Wimmer-Greinecker, Mário Gesteira Costa, Mozart Augusto Soares de Escobar, Roberto Diniz, Antônio Césio, Frederico Vasconcelos, Alexandre Menezes, Robert Poser, Jerry Riebman   +9 more
doaj   +1 more source

Integrated Single‐Cell and Spatial Transcriptomics Reveal Convergence on a Senescence‐Associated B Cell–MIF Signaling Axis in Joint Aging and Osteoarthritis Progression

Advanced Science, EarlyView.
Single‐cell and spatial transcriptomics implicate senescent B cells and macrophage migration inhibitory factor (MIF) signaling in aging and osteoarthritic joints. An injectable hydrogel combining quercetin with siRNA targeting MIF attenuates cartilage degeneration in a mouse model of osteoarthritis.
Weida Li, Yi Wang, Yongqing You, Yue Cui, Jiayun Liu, Xingbiao Ma, QiuYu Zhu, Qiang Wu, Zanjing Zhai, Zuyan Lu, Kerong Dai, Ye Sun   +11 more
wiley   +1 more source

The atrial neoannulus technique for mitral valve replacement in patients with severe mitral annular calcificationCentral MessagePerspective

JTCVS Techniques
Objectives: Mitral valve replacement (MVR) in patients with severe mitral annular calcification (MAC) remains technically challenging because of the risk of annular disruption and associated complications.
Zubair A. Hashmi, MD, Rahul Rajeev, MBBS, Ye In Christopher Kwon, BA, Graham Gardner, MD, Holly Caboti-Jones, BS, Vigneshwar Kasirajan, MD   +5 more
doaj   +1 more source

Prótesis sin sutura: ¿es posible reducir la tasa de bloqueos postoperatorios modificando la técnica de implante?

Cirugía Cardiovascular, 2018
Resumen: Introducción: El recambio valvular aórtico con prótesis sin sutura Perceval S se asocia a un aumento en la tasa de bloqueo auriculoventricular postoperatorio que precisa implante de marcapasos definitivo, comparado con las bioprótesis ...
Miguel González-Barbeito, Patricia Pardo-Martinez, Francisco Estévez-Cid, Carlos Velasco-García de Sierra, Jorge Rodriguez-Garrido, Yago Vilela-González, María García-Vieites, Laura Fernández-Arias, Carmen Iglesias-Gil, Victor X. Mosquera-Rodriguez, Jose María Herrera-Noreña, José J. Cuenca-Castillo   +11 more
doaj   +1 more source

PHGDH‐Mediated Serine Metabolism in Nucleus Pulposus Cells Is a Potential Therapeutic Target for Intervertebral Disc Degeneration

Advanced Science, EarlyView.
When nucleus pulposus cells senesce, PHGDH decreases, reducing serine synthesis and glutathione, impairing antioxidant capacity. The intermediate α‐KG also drops, lowering JMJD3 demethylase activity, increasing H3K27me3 at the Rap1b promoter, and reducing Rap1b expression, whose down‐regulation in turn activates mTORC1 and suppresses autophagy ...
Hao‐Wei Xu, Sheng‐Jie Chang, Xiao‐Wei Liu, Shu‐Bao Zhang, Ying‐Jie Wang, Shan‐Jin Wang   +5 more
wiley   +1 more source

Histopathological Study of Periapical Inflammation Following Preparation of the Root Canal with Conventional and Profile Rotary Instrumentation in Teeth of Cats

Frontiers in Dentistry, 2005
Statement of Problem: Various factors are involved in causing inflammation following root canal treatment. Controlling these factors may relieve the related pain. One of these factors is extrusion of debris beyond the apex.
M. Bidar, S. Moradi, MH. Zarrabi, B. Barikbin   +3 more
doaj  

Differences in predominant collagen fiber orientation between dorsal and plantar trabecular bone tracts of adult mule deer calcanei suggest strain‐mode‐specific adaptation

The Anatomical Record, EarlyView.
Polarized microscopic images of the outer bone cortex (a and b) and deeper trabecular bone (c and d) of the deer calcaneus in thin cross‐sections. The brighter gray levels reflect more oblique‐to‐transverse collagen fibers in the compression/dorsal bone (a, c) and the darker gray levels reflect more longitudinal collagen in the tension/plantar bone (b,
John G. Skedros, John T. Cronin, Chad S. Mears, Brett W. Richards   +3 more
wiley   +1 more source