Results 11 to 20 of about 948 (102)

Different Effects of Mg2+ and Zn2+ on the Two Sites for Alkylammonium Compounds in Pseudomonas aeruginosa Phosphorylcholine Phosphatase [PDF]

Enzyme Research, Volume 2011, Issue 1, 2011., 2011
Pseudomonas aeruginosa phosphorylcholine phosphatase (PchP) catalyzes the hydrolysis of phosphorylcholine (Pcho), is activated by Mg2+ or Zn2+, and is inhibited by high concentrations of substrate.
Beassoni, Paola Rita, Boetsch, Cristhian, Domenech, Carlos Eduardo, Lisa, Angela Teresita, Otero, Lisandro Horacio   +4 more
core   +4 more sources

Disentangling the formation, mechanism, and evolvement of the covalent methanesulfonyl fluoride acetylcholinesterase adduct: Insights into an aged-like inactive complex susceptible to reactivation by a combination of nucleophiles. [PDF]

Protein Sci
Abstract Chemical warfare nerve agents and pesticides, known as organophosphorus compounds inactivate cholinesterases (ChEs) by phosphorylating the serine hydroxyl group located at the active site of ChEs. Over the course of time, phosphorylation is followed by loss of an organophosphate‐leaving group and the bond with ChEs becomes irreversible, a ...
Stojan J, Pesaresi A, Meden A, Lamba D.
europepmc   +2 more sources

Light-Activated Pharmacological Tools for Exploring the Cholinergic System. [PDF]

Med Res Rev
ABSTRACT Cholinergic transmission plays a critical role in both the central and peripheral nervous systems, affecting processes such as learning, memory, and inflammation. Conventional cholinergic drugs generally suffer from poor selectivity and temporal precision, leading to undesired effects and limited therapeutic efficacy. Photopharmacology aims to
Colleoni A, Galli G, Dallanoce C, De Amici M, Gorostiza P, Matera C.   +5 more
europepmc   +2 more sources

Rational Design in Photopharmacology with Molecular Photoswitches

Angewandte Chemie, Volume 135, Issue 30, July 24, 2023., 2023
The state of the art of rational design in photopharmacology is analyzed with a focus on E‐Z molecular photoswitches and on computer‐aided approaches. By meticulously examining the design strategies of photopharmacology through the lens of medicinal chemistry, this review identifies existing trends and novel opportunities for the development of ...
Piermichele Kobauri, Frank J. Dekker, Wiktor Szymanski, Ben L. Feringa   +3 more
wiley   +2 more sources

Neuromuscular Blocking Agents and Cancer: A Narrative Review

Journal of Clinical Pharmacy and Therapeutics, Volume 2023, Issue 1, 2023., 2023
Objective. Neuromuscular blocking agents (NMBAs) are part of the three elements of general anaesthesia (sedation, analgesia, and muscle relaxation), which can relax muscles and facilitate intubation and surgery. It has been reported that cancer cells are prone to invasion or metastasis during surgery, but various anaesthetics are currently used in ...
Rui Chen, Yan Sun, Yufan Li, Xiaoke Dou, Maosha Dai, Shujun Sun, Yun Lin, Pranshu Sahgal   +7 more
wiley   +1 more source

Quantifying the tolerance of chick hip joint development to temporary paralysis and the potential for recovery

Developmental Dynamics, Volume 250, Issue 3, Page 450-464, March 2021., 2021
ABSTRACT Background Abnormal fetal movements are implicated in joint pathologies such as arthrogryposis and developmental dysplasia of the hip (DDH). Experimentally induced paralysis disrupts joint cavitation and morphogenesis leading to postnatal abnormalities.
Devi L. Bridglal, Colin J. Boyle, Rebecca A. Rolfe, Niamh C. Nowlan   +3 more
wiley   +1 more source

Dual Binding Site and Selective Acetylcholinesterase Inhibitors Derived from Integrated Pharmacophore Models and Sequential Virtual Screening

BioMed Research International, Volume 2014, Issue 1, 2014., 2014
In this study, we have employed in silico methodology combining double pharmacophore based screening, molecular docking, and ADME/T filtering to identify dual binding site acetylcholinesterase inhibitors that can preferentially inhibit acetylcholinesterase and simultaneously inhibit the butyrylcholinesterase also but in the lesser extent than ...
Shikhar Gupta, C. Gopi Mohan, Sandro Cosconati   +2 more
wiley   +1 more source

Phosphorylcholine Phosphatase: A Peculiar Enzyme of Pseudomonas aeruginosa

Enzyme Research, Volume 2011, Issue 1, 2011., 2011
Pseudomonas aeruginosa synthesizes phosphorylcholine phosphatase (PchP) when grown on choline, betaine, dimethylglycine or carnitine. In the presence of Mg2+ or Zn2+, PchP catalyzes the hydrolysis of p‐nitrophenylphosphate (p‐NPP) or phosphorylcholine (Pcho).
Carlos Eduardo Domenech, Lisandro Horacio Otero, Paola Rita Beassoni, Angela Teresita Lisa, Heung Chin Cheng   +4 more
wiley   +1 more source

Near‐Infrared Diffuse Optical Tomography

Disease Markers, Volume 18, Issue 5-6, Page 313-337, 2002., 2002
Diffuse optical tomography (DOT) is emerging as a viable new biomedical imaging modality. Using near‐infrared (NIR) light, this technique probes absorption as well as scattering properties of biological tissues. First commercial instruments are now available that allow users to obtain cross‐sectional and volumetric views of various body parts ...
A. H. Hielscher, A. Y. Bluestone, G. S. Abdoulaev, A. D. Klose, J. Lasker, M. Stewart, U. Netz, J. Beuthan   +7 more
wiley   +1 more source

Exploring the Multifunctional Agents of Flavonoid‐Rich Beet Leaf Extracts: Insights From Experimental and Computational Studies

Food Safety and Health, Volume 3, Issue 4, Page 723-739, October 2025.
ABSTRACT This study evaluated the multifunctional ability of Beta vulgaris leaves in dual therapy for Alzheimer's disease (AD) and type 2 diabetes (T2D). Flavonoid‐rich extracts of B. vulgaris leaves (FREBVL) were tested for their antidiabetic properties. The inhibition of α‐amylase and α‐glucosidase was assessed. Anti‐cholinesterase activities against
Gideon Ampoma Gyebi, Damilare Emmanuel Rotimi, Moyosoreoluwa Oduba, Ifeoma Nnonyelu, Matthew Iyobhebhe, Musiliyu Ayofe Salawu, Adebola Busola Ojo, Odunayo Anthonia Taiwo, Adesoji Alani Olanrewaju, Abel Kolawole Oyebamiji, Mubarak Alruwaili, Naif H. Ali, Saud A. Alnaaim, Bshra A. Alsfouk, Gaber El‐Saber Batiha, Oluwafemi Adeleke Ojo   +15 more
wiley   +1 more source