Results 51 to 60 of about 849,846 (204)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Effects of Multiplicative Noise in Bistable Dynamical Systems

Entropy
This study explores the escape dynamics of bistable systems influenced by multiplicative noise, extending the classical Kramers rate formula to scenarios involving state-dependent diffusion in asymmetric potentials.
Sara C. Quintanilha Valente, Rodrigo da Costa Lima Bruni, Zochil González Arenas, Daniel G. Barci   +3 more
doaj   +1 more source

Alpha-decay Rates of Yb and Gd in Solar Neutrino Detectors

, 2002
The $\alpha$-decay rates for the nuclides $^{168,170,171,172,173,174,176}$Yb and $^{148,150,152,154}$Gd have been estimated from transmission probabilities in a systematic $\alpha$-nucleus potential and from an improved fit to $\alpha$-decay rates in the
Bahcall J N, de Vries H, Delion D S, García F, Geiger H, Keller K A, LENS (Low Energy Neutrino Spectroscopy) Collaboration, M Fujiwara, Meyer J-P, P Mohr, Raman S, T Kawabata, Taagepera R, Wong S S M   +13 more
core   +2 more sources

Estimates of Stellar Weak Interaction Rates for Nuclei in the Mass Range A=65-80 [PDF]

, 2002
We estimate lepton capture and emission rates, as well as neutrino energy loss rates, for nuclei in the mass range A=65-80. These rates are calculated on a temperature/density grid appropriate for a wide range of astrophysical applications including ...
Fuller, George M., Pruet, Jason
core   +3 more sources

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Extrapolating empirical measurements of wastewater exfiltration from sanitary sewers to estimate watershed-scale fecal pollution loading in urban stormwater runoff

Frontiers in Environmental Science
Inflow and infiltration are well-known issues for sanitary sewer collection systems, but exfiltration is understudied and rarely empirically quantified.
Joshua A. Steele, Adriana González-Fernández, John F. Griffith, Darcy Ebentier McCargar, Sierra Wallace, Kenneth C. Schiff   +5 more
doaj   +1 more source

Automatic Decay-Rate Meter [PDF]

The Journal of the Acoustical Society of America, 1966
An automatic meter for measuring the decay rate in a room is described. The meter is based on a proposal by M. R. Schroeder [J. Acoust. Soc. Am. 37, 409–412 (1965)] utilizing the relationship between the integrated impulse response and the average noise response between two points in a reverberent enclosure.
openaire   +1 more source

Negative modes and the decay-rate transition [PDF]

Physical Review B, 1999
We investigate a relationship between the number of the negative modes around periodic instanton solution and the type of the decay-rate transition. It is shown that for the case of first-order decay-rate transition the lowest positive mode at low energy periodic instanton becomes additional negative mode at high energy regime, while in the second ...
Lee, Soo-Young, Kim, Hungsoo, Park, D. K., Kim, Jae Kwan   +3 more
openaire   +2 more sources

Long-Term Variations in the Growth and Decay Rates of Sunspot Groups

, 2011
Using the combined Greenwich (1874-1976) and Solar Optical Observatories Network (1977-2009) data on sunspot groups, we study the long-term variations in the mean daily rates of growth and decay of sunspot groups. We find that the minimum and the maximum
Ch. Torrence, D.H. Hathaway, D.O. Gough, F. Moreno-Insertis, F. Ward, G. Lustig, J. Javaraiah, J. Javaraiah, J. Javaraiah, J. Javaraiah, J. Javaraiah, J. Javaraiah, J.G. Berryman, M. Dikpati, P.J. Pulkkinen, R. Komm, R. Rosner, R.F. Howard, R.F. Howard, T.J. Ulrych, V. Martínez Pillet, Y.-M. Wang   +21 more
core   +1 more source

On the Cauchy Problem for a Simplified Compressible Oldroyd–B Model Without Stress Diffusion

Mathematics
In this paper, we are concerned with the Cauchy problem of the compressible Oldroyd-B model without stress diffusion in Rn(n=2,3). The absence of stress diffusion introduces significant challenges in the analysis of this system.
Yuanyuan Dan, Feng Li, Haitao Ma, Yajuan Zhao   +3 more
doaj   +1 more source