Decellularization of chondrocyte-encapsulated collagen microspheres: A three-dimensional model to study the effects of acellular matrix on stem cell fate [PDF]
, 2009 Extracellular matrix (ECM) partially constitutes the stem cell niche. Reconstituting the ECM niche in a three-dimensional (3D) configuration will significantly enhance our understanding of how stem cells interact with and respond to the ECM niche.
Chan, BP +4 more
core +1 more source
Decellularization methods for developing porcine corneal xenografts and future perspectives
Xenotransplantation, 2019 Corneal transplantation is the only option to cure corneal opacities. However, there is an imbalance between supply and demand of corneal tissues in the world.
A. Isidan +7 more
semanticscholar +1 more source
Advances in Bioprinting to Model Immune‐Mediated Skin Diseases
Advanced Healthcare Materials, EarlyView.This review explores how 3D bioprinting drives innovation in developing in vitro skin models that mimic immune‐mediated diseases. It highlights current technologies, key applications in studying skin pathologies, and emerging challenges. The review points toward future opportunities for improving disease modeling and advancing therapeutic and cosmetic ...
Andrea Ulloa‐Fernández +4 more
wiley +1 more source
Advanced Healthcare Materials, EarlyView.Stromal vascular fraction (SVF) may enhance nerve repair, especially when delivered in a self‐assembling peptide hydrogel (SAPH). In vitro, softer SAPH increased neuronal explant outgrowth and supported greater SVF viability and proliferation. In a rat sciatic defect, SVF in an optimized SAPH produced motor and sensory recovery equivalent to autograft ...
Liam A. McMorrow +6 more
wiley +1 more source
A sterilization method for human decellularized vaginal matrices
Scientific ReportsVaginal reconstruction is necessary for various congenital and acquired conditions, including vaginal aplasia, trauma, tumors, and gender incongruency. Current surgical and non-surgical treatments often result in significant complications. Decellularized
Jayson Sueters +5 more
doaj +1 more source
Making microenvironments : a look into incorporating macromolecular crowding into in vitro experiments, to generate biomimetic microenvironments which are capable of directing cell function for tissue engineering applications [PDF]
, 2017 Biomimetic microenvironments are key components to successful cell culture and tissue engineering in vitro. One of the most accurate biomimetic microenvironments is that made by the cells themselves. Cell-made microenvironments are most similar to the in
Benny, Paula, Raghunath, Michael
core +1 more source
Advanced Healthcare Materials, EarlyView.An amine‐functionalized chitosan and hydrolyzed dECM composite promotes cutaneous regeneration by modulating oxidative stress and inflammatory pathways. The material accelerates wound closure and stimulates hair follicle activation in UV‐damaged cutaneous tissue.
Yu‐Jin Kim +11 more
wiley +1 more source
Bioengineering thymus organoids to restore thymic function and induce donor-specific immune tolerance to allografts [PDF]
, 2015 One of the major obstacles in organ transplantation is to establish immune tolerance of allografts. Although immunosuppressive drugs can prevent graft rejection to a certain degree, their efficacies are limited, transient, and associated with severe side
Alpdogan +82 more
core +1 more source
Bioprinted Constructs in the Regulatory Landscape: Current State and Future Perspectives
Advanced Materials, EarlyView.Bioprinting has rapidly emerged as a transformative technology in biomedical research, offering unprecedented potential to replicate complex tissues. Despite its promise, clinical translation remains limited due to regulatory hurdles. This review explores global regulatory frameworks, comparing approaches in the EU, U.S., China, and Australia, and ...
Francesca Perin +6 more
wiley +1 more source