Results 71 to 80 of about 30,040 (330)

Osteocytes under Mechanical Loading Regulate PC‐3 Cancer Cell–Mineral Interactions during Early‐Stage Metastasis to Bone

Advanced Biology, EarlyView.
In this study, Seaman et al. develop a co‐culture assay to examine interactions between prostate cancer cells and mineralized osteoblasts in a microfluidic platform. The authors collect conditioned media from static or flow‐stimulated osteocytes and demonstrate that mechanical loading of osteocytes regulates the growth of prostate cancer cells and ...
Kimberly Seaman, Bryan Guo, William W. Du, Burton Yang, Yu Sun, Lidan You   +5 more
wiley   +1 more source

Total aortic arch replacement: Superior ventriculo-arterial coupling with decellularized allografts compared with conventional prostheses [PDF]

, 2014
BACKGROUND: To date, no experimental or clinical study provides detailed analysis of vascular impedance changes after total aortic arch replacement.
Hartyánszky, István, Istók, Roland, Merkely, Béla, Merkely, Gergő, Németh, Balázs Tamás, Radovits, Tamás, Soós, Pál, Szabó, Gábor, Veres, Gábor, Weymann, Alexander   +9 more
core   +6 more sources

Determining the optimal pancreatic decellularization protocol, taking into account tissue morphological features

Вестник трансплантологии и искусственных органов, 2022
Introduction. Developing a tissue-engineered pancreatic construct (TEPC) involves a search for matrices/scaffolds capable of mimicking the structure and composition of the natural extracellular matrix (ECM), which is an important component of the tissue ...
A. S. Ponomareva, N. V. Baranova, L. A. Kirsanova, G. N. Bubentsova, E. A. Nemets, I. A. Miloserdov, V. I. Sevastianov   +6 more
doaj   +1 more source

Rapid production of human liver scaffolds for functional tissue engineering by high shear stress oscillation-decellularization [PDF]

, 2017
The development of human liver scaffolds retaining their 3-dimensional structure and extra-cellular matrix (ECM) composition is essential for the advancement of liver tissue engineering.
A Bader, A Dash, A Vivares, AJ Engler, BD Elder, BE Uygun, C Trautwein, CM Nelson, D Mavri-Damelin, D Schuppan, D Sokocevic, DE Discher, DK Mishra, E Meezan, FJ Rodriguez, G Mazza, G Mazza, G Orlando, G Steinhoff, G Totonelli, I Mederacke, I Notingher, J Folkman, JJ Song, JM Fishman, JP Guyette, K Rombouts, K Schenke-Layland, M Monici, M Piccoli, M Pinzani, P Bornstein, P Gissen, P Lin, P Maghsoudlou, PM Crapo, R Ahmadi, RG Wells, S Baiguera, S Marastoni, SE Gilpin, SK Goh, SL Dahl, TD Schmittgen, TT Nguyen, Y Wang   +45 more
core   +6 more sources

A Vascularized Microphysiological System Reproducing Endochondral Ossification in Vitro to Study Ewing Sarcoma Proliferation and Migration

Advanced Functional Materials, EarlyView.
A biofabricated 3D in vitro model recapitulating endochondral ossification (ECO) is described, mimicking the steps from condensation to chondrogenesis and hypertrophy, culminating with vascularization of the hypertrophic construct. As a model proof of concept application, Ewing Sarcoma cells are seeded in the model, showing modifications in their ...
Maria Vittoria Colombo, Chiara Arrigoni, Tobias Faehling, Antonietta Verrillo, Viviana Secci, Thomas G. P. Grünewald, Giuseppe Talò, Alexandra Kummer, Jorge Gonzalez, Vincenzo De Rosa, Christian Candrian, Andrea Barbero, Florencia Cidre‐Aranaz, Matteo Moretti   +13 more
wiley   +1 more source

Engineering an endocrine Neo-Pancreas by repopulation of a decellularized rat pancreas with islets of Langerhans [PDF]

, 2017
Decellularization of pancreata and repopulation of these non-immunogenic matrices with islets and endothelial cells could provide transplantable, endocrine Neo- Pancreata.
Andreou, A., Everwien, H., Gassner, J., Geisel, D., Haep, N., Hillebrandt, K.-H., Kluge, M., Lippert, S., Napierala, H., Noesser, M., Polenz, D., Pratschke, J., Raschzok, N., Sauer, I. M., Seiffert, N., Selke, A. Reutzel, Struecker, B., Tang, P., Teegen, E., Tintemann, M.   +19 more
core   +1 more source

The Route to Artery Mimetics: Hybrid Bioinks for Embedded Bioprinting of Multimaterial Cylindrical Models

Advanced Functional Materials, EarlyView.
The fabrication of a cellularized, multilayered 3D printed cylindrical model comprising hybrid bioinks inspired by the natural extracellular environment as an approach to artery mimetics, is presented. Using embedded bioprinting, interlayer crosslinking of self‐supporting concentric cylinders is achieved.
Uxue Aizarna‐Lopetegui, Ada Herrero‐Ruiz, Monize C. Decarli, Ane Urigoitia‐Asua, Karla Chavarri‐Urraca, Lorenzo Moroni, Malou Henriksen‐Lacey, Dorleta Jimenez de Aberasturi   +7 more
wiley   +1 more source

EXPERIENCE OF PERFUSION RECELLULARIZATION OF BIOLOGICAL LUNG SCAFFOLD IN RATS

Вестник трансплантологии и искусственных органов, 2016
Aim. The main aim of our research is to evaluate the process of rat lung decellularization and recellularization as the initial step of tissue-engineered organs creation.Materials and methods.
E. V. Kuevda, E. A. Gubareva, A. S. Sotnichenko, I. S. Gumenyuk, I. V. Gilevich, I. S. Polyakov, V. A. Porhanov, S. N. Alekseenko, P. Macchiarini   +8 more
doaj   +1 more source

Efficient Decellularization of the Full-Thickness Rat-Derived Abdominal Wall to Produce Acellular Biologic Scaffolds for Tissue Reconstruction: Promising Evidence Acquired from In Vitro Results

Bioengineering, 2023
Background: Functional restoration of abdominal wall defects represents one of the fundamental challenges of reconstructive surgery. Synthetic grafts or crosslinked animal-derived biological grafts are characterized by significant adverse reactions ...
George Skepastianos, Panagiotis Mallis, Epameinondas Kostopoulos, Efstathios Michalopoulos, Vasileios Skepastianos, Chrysoula Palazi, Lucia Pannuto, Gerasimos Tsourouflis   +7 more
doaj   +1 more source

Photothermal Hydrogel with Mn3O4 Nanoparticles Alleviates Intervertebral Disc Degeneration by Scavenging ROS and Regulating Extracellular Matrix Metabolism

Advanced Functional Materials, EarlyView.
The MPTT‐nanozyme‐hydrogel system (Mn3O4@ChS‐HA) provides a multifunctional therapeutic strategy for intervertebral disc degeneration (IVDD), effectively targeting oxidative stress and enhancing AF repair by restoring extracellular matrix (ECM) and redox homeostasis.
Yangyang Chen, Chan Xue, Feifei Ni, Binwu Hu, Miaoheng Yan, He Zhang, Yuxiang Hu, Xiaoyao Peng, Guangfang Li, Yu Han, Hongjian Liu, Zengwu Shao, Qin Wang, Yulong Wei   +13 more
wiley   +1 more source