Results 51 to 60 of about 12,375 (249)

Combating Inflammation and Promoting Anabolism in Osteoarthritic Cartilage Defect With an MMP13‐Sensing Dual‐Drug Scaffold

Advanced Science, EarlyView.
ABSTRACT Osteoarthritis (OA) is a widespread degenerative joint condition marked by progressive cartilage breakdown, and a chronic inflammatory microenvironment, where conventional therapies largely fail to halt disease progression. To address this unmet need, an intra‐articularly implantable, disease‐responsive scaffold was developed for combinatorial
Zhen Zhang, Bangheng Liu, Yulei Mu, Huiqun Zhou, Liang Ma, Chenjie Xu, Dong‐An Wang   +6 more
wiley   +1 more source

Decellularization of Trachea With Combined Techniques for Tissue-Engineered Trachea Transplantation [PDF]

Clinical and Experimental Otorhinolaryngology, 2019
Objectives The purpose of this study is to shorten the decellularization time of trachea by using combination of physical, chemical, and enzymatic techniques.
Aysegul Batioglu-Karaaltin, Ercüment Ovali, Mehmet V Karaaltin, Murat Yener, Mehmet Yılmaz, Fatma Eyüpoğlu, Yetkin Zeki Yılmaz, Erol Rüştü Bozkurt, Necdet Demir, Esma Konuk, Ergun Süreyya Bozdağ, Özgür Yiğit, Harun Cansiz   +12 more
doaj   +1 more source

Optimization of Complete Rat Heart Decellularization Using Artificial Neural Networks

Micromachines, 2022
Whole organ decellularization techniques have facilitated the fabrication of extracellular matrices (ECMs) for engineering new organs. Unfortunately, there is no objective gold standard evaluation of the scaffold without applying a destructive method ...
Greta Ionela Barbulescu, Taddeus Paul Buica, Iacob Daniel Goje, Florina Maria Bojin, Valentin Laurentiu Ordodi, Gheorghe Emilian Olteanu, Rodica Elena Heredea, Virgil Paunescu   +7 more
doaj   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

The tested decellularization protocols.

, 2019
The tested decellularization protocols.
Mijeong Jeon (400448), Hyo-Seol Lee (501218), Hyoju Son (7251755), Ik-Hwan Kim (662101), Chung-Min Kang (7251758), Je Seon Song (7251761), Hyung-Jun Choi (400452)   +6 more
core   +1 more source

Effects of chemical and physical methods on decellularization of murine skeletal muscles

Anais da Academia Brasileira de Ciências, 2021
Volumetric muscle loss causes functional weakness and is often treated with muscle grafts or implant of biomaterials. Extracellular matrices, obtained through tissue decellularization, have been widely used as biological biomaterials in tissue ...
CARLA M.F.C. MIRANDA, LUCIANO C.P.C. LEONEL, RAFAEL R. CAÑADA, DURVANEI A. MARIA, MARIA ANGÉLICA MIGLINO, MARIANO DEL SOL, SONJA E. LOBO   +6 more
doaj   +1 more source

Xenoantigenicity of porcine decellularized valves [PDF]

Journal of Cardiothoracic Surgery, 2017
The xenoantigenicity of porcine bioprosthetic valves is implicated as an etiology leading to calcification and subsequent valve failure. Decellularization of porcine valves theoretically could erase the antigenicity of the tissue leading to more durable prosthetic valves, but the effectiveness of decellularization protocols in regard to completely ...
Meghana R. K. Helder, Nicholas J. Stoyles, Brandon J. Tefft, Ryan S. Hennessy, Rebecca R. C. Hennessy, Roy Dyer, Tyra Witt, Robert D. Simari, Amir Lerman   +8 more
openaire   +3 more sources

Ultra‐Radiostable Covalent Conformationally Interlocked Networks Enabling a Universal Radiometal‐Labeling Platform for Cancer Radioembolization

Advanced Science, EarlyView.
Conjugated poly(imide dioxime)‐based microspheres establish a radiometal coordination‐driven conformational interlocked network with ultra‐high radiostability. This platform enables low‐temperature, multi‐radionuclide labeling for SPECT/PET/MRI imaging and radionuclide therapy. Mechanistic insights from EXAFS and DFT reveal enhanced stability, while in
Xiao Xu, Zhenwen Zhao, Yangjie Wang, Zhigang Liu, Zhijie Liu, Xiaoling Li, Zhichen Mao, Lu Xu, Gan Lin, Gang Liu, Hongjuan Ma   +10 more
wiley   +1 more source

Characterization of a Decellularized Sheep Pulmonary Heart Valves and Analysis of Their Capability as a Xenograft Initial Matrix Material in Heart Valve Tissue Engineering

Bioengineering, 2023
In order to overcome the disadvantages of existing treatments in heart valve tissue engineering, decellularization studies are carried out. The main purpose of decellularization is to eliminate the immunogenicity of biologically derived grafts and to ...
Müslüm Süleyman İnal, Cihan Darcan, Ali Akpek   +2 more
doaj   +1 more source

Harmonizing Rigidity and Flexibility: Embedding COF Quantum Dots Into Extracellular Matrix Gel as Carbon Monoxide Depot for Acoustically Triggered Time‐Programmable Anti‐Infective Therapy

Advanced Science, EarlyView.
A rigid‑flexible integrated CO depot is engineered by embedding rigid COFQDs into a flexible ECM gel network. The rigid framework enables high‑capacity CO storage and sonodynamic bacterial killing, while the flexible ECM gel controls sustained CO release, collectively eradicating multidrug‑resistant infection and promoting scarless healing.
Baohong Sun, Fang Han, Chunxiao Zhu, Zhiyuan Yang, Haoru Wang, Jinpei Mei, Jie Chen, Jingwen Zhu, Zihan Bo, Taju Wu, Xiaogang Zhou, Tao Ma, Yutian Su, Youhui Lin   +13 more
wiley   +1 more source