Results 131 to 140 of about 477,117 (342)
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
The Work Environment Index: Technical Background Paper [PDF]
The vast majority of Americans work for a living. The track record of different states varies widely when it comes to providing decent opportunities for working people.
James Heintz +2 more
core
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Global production methods and women employment in garment units of Mumbai Metropolitan Region [PDF]
Production in the garment unit is depending on technology, efficiency and skills of workers. If the labors are young and more educated then they adjust with flexible production methods.
Sanjay R, Sanjay
core +1 more source
Determinants of Decent full-time Work in the Spanish employment market: An analysis of Social Security with micro-data [PDF]
, 2011 Este trabajo tiene como objetivo identificar los determinantes de ocupar un puesto de trabajo decente (Decent Work) por cuenta ajena y a tiempo completo (TC) en el mercado laboral español.
Pedraza, Pablo de, Villacampa, Alberto
core +1 more source
The Relationship Between Sex Discrimination and Job and Life satisfaction in Female Employees: The Mediating Effects of Work Volition and Decent Work [PDF]
, 2021 Seran Lee, Ki-Hak Lee
openalex +1 more source
Molecular cancer prevention: Intercepting disease
Molecular Oncology, EarlyView.Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco +2 more
wiley +1 more source
Working But Poor in America [PDF]
, 1995 [Excerpt] At a time when the nation is wrestling with the question of reforming welfare and forging policies that bridge the gap between dependence and work, the fact is that, for millions, work does not allow them to provide a decent standard of living ...
Parente, Frank
core +1 more source