Results 41 to 50 of about 18,499 (206)

Single cell transcriptional signatures of the human placenta in term and preterm parturition

eLife, 2019
More than 135 million births occur each year; yet, the molecular underpinnings of human parturition in gestational tissues, and in particular the placenta, are still poorly understood. The placenta is a complex heterogeneous organ including cells of both
Roger Pique-Regi, Roberto Romero, Adi L Tarca, Edward D Sendler, Yi Xu, Valeria Garcia-Flores, Yaozhu Leng, Francesca Luca, Sonia S Hassan, Nardhy Gomez-Lopez   +9 more
doaj   +1 more source

Endometrial Epithelial Lactate Deficiency Drives CD8+ T‐Cells Dysregulation in Unexplained Recurrent Implantation Failure

Advanced Science, EarlyView.
Unexplained recurrent implantation failure (RIF) represents a significant clinical challenge. Our results demonstrate that reduced lactate production in the RIF endometrium impairs the suppression of cytotoxic CD8+ T‑cells, allowing their proliferation and thereby disrupting the local immune balance essential for successful embryo implantation.
Yuanlin He, Kang Ke, Qingxia Meng, Yichun Guan, Jichun Tan, Hong Lv, Boxian Huang, Chan Tian, Qinyan Zou, Mingxing An, Yao Gao, Jingjing Chen, Xiaoyu Wei, Xi Wang, Hongxia Ma, Yuan Lin, Feiyang Diao, Yayun Gu, Zhibin Hu   +18 more
wiley   +1 more source

Elevated levels of exogenous prolactin promote inflammation at the maternal-fetal interface via the JAK2/STAT5B signaling axis

Frontiers in Immunology
The placenta is a unique organ with various immunological and endocrinological roles that modulate maternal and fetal physiology to promote maternal-fetal tolerance, pregnancy maintenance, and parturition at term. During pregnancy, the hormone prolactin (
Alycia Williams, Daniel J. Hossack, Nia Thompson, Yul Eum Sim, Cristina Wilson, Viviane Schuch, Tiffany Hailstorks, Rana Chakraborty, Erica L. Johnson, Erica L. Johnson, Erica L. Johnson   +10 more
doaj   +1 more source

HLA-G in human early pregnancy: Control of uterine immune cell activation and likely

Biomedical Journal, 2015
Despite a number of controversies, the functional importance of human leukocyte antigen G (HLA-G) in early human pregnancy is now sustained by a large amount of sound data.
Philippe Le Bouteiller
doaj   +1 more source

Placental crises: disruptive selection and maternal under‐investment as the foundations of mammalian placental evolution and dysfunction

Biological Reviews, EarlyView.
ABSTRACT Among the vertebrates, mammals are notable for the dominance of live birth and placental nutrition. The structural diversity of the mammalian placenta is remarkable, despite sharing a single common ancestor and conserved physiological functions.
Davis Laundon, Neil J. Gostling, Ian G. Reddin, Bram G. Sengers, Pascale Chavatte‐Palmer, Rohan M. Lewis   +5 more
wiley   +1 more source

EcoViz: a tool for visual analysis and photorealistic rendering of forest landscape model simulations

Ecography, EarlyView.
Simulation outputs from forest landscape models are complex, and tools for their visual analysis and effective communication are often limited. In this paper, we present EcoViz, a novel, open‐source visualisation platform designed to complement existing forest models by providing advanced 3D visualisation capabilities.
Werner Rammer, Eric Guérin, Patrick Marais, Adrien Peytavie, Konrad Kapp, Eric Galin, Rupert Seidl, James Gain   +7 more
wiley   +1 more source

Decidual-Placental Immune Landscape During Syngeneic Murine Pregnancy

Frontiers in Immunology, 2018
Adaptive immune system, principally governed by the T cells—dendritic cells (DCs) nexus, is an essential mediator of gestational fetal tolerance and protection against infection.
Yan Li, Gladys E. Lopez, Jessica Vazquez, Yan Sun, Yan Sun, Melina Chavarria, Payton N. Lindner, Samantha Fredrickson, Nathan Karst, Aleksandar K. Stanic, Aleksandar K. Stanic   +10 more
doaj   +1 more source

Interleukin-15 deficient rats have reduced osteopontin at the maternal-fetal interface

Frontiers in Cell and Developmental Biology, 2023
Introduction: Uterine Natural Killer (NK) cells are the predominant immune cells within the decidua during early pregnancy. These cells are thought to regulate aspects of decidualization and placental development, but their functions remain poorly ...
Kelly J. Baines, Michelle S. Klausner, Violet S. Patterson, Stephen J. Renaud, Stephen J. Renaud   +4 more
doaj   +1 more source

Endometrial Stromal Cell Senescence: A Non‐Negligible Factor in Recurrent Pregnancy Loss

iMetaMed, EarlyView.
As populations age, links between female reproductive aging and infertility are increasingly evident. Cellular senescence, characterized by near‐irreversible cell‐cycle arrest and accumulation of damage, can impair tissue function. In the endometrium, aberrant senescence of endometrial stromal cells (EnSCs) may compromise receptivity, hinder embryo ...
Shuang Wu, Cenlan Bu, Qinzheng Xu, Xi Cheng, Junrong Zhang, Jinling Chen, Yun‐Zhao Xu   +6 more
wiley   +1 more source

Innate Immune Mechanisms to Protect Against Infection at the Human Decidual-Placental Interface

Frontiers in Immunology, 2020
During pregnancy, the placenta forms the anatomical barrier between the mother and developing fetus. Infectious agents can potentially breach the placental barrier resulting in pathogenic transmission from mother to fetus.
Regina Hoo, Regina Hoo, Annettee Nakimuli, Annettee Nakimuli, Roser Vento-Tormo, Roser Vento-Tormo   +5 more
doaj   +1 more source