Results 71 to 80 of about 32,908 (297)

MicroRNA Profiles in Spontaneous Decidualized Menstrual Endometrium and Early Pregnancy Decidua with Successfully Implanted Embryos

PLoS ONE, 2016
To comparatively analyze the human microRNA (miRNA) profiles between spontaneous decidualized menstrual endometrium and early pregnancy decidua by an in-depth sequencing of miRNAs.
Yu Wang, Yang Lv, Shujun Gao, Yuanyuan Zhang, Jiajia Sun, Chunling Gong, Xiujuan Chen, Guangpeng Li   +7 more
semanticscholar   +1 more source

HRS Degradation‐Induced Nicotinamide Deficiency in Placental Extracellular Vesicles Triggers Preeclampsia by Disrupting Maternal‐Fetal Immune Homeostasis

Advanced Science, EarlyView.
This study shows that lower NAM levels in PE‐derived pEVs correlate with disease severity. NAM‐deficient pEVs reduce Th1 and Th17 inhibition, leading to PE‐like symptoms. NAM in pEVs inhibits Th1 via SIRT1 and Th17 via macrophages. Reduced NAM in PE‐EVs is due to decreased HRS expression in trophoblasts, resulting from elevated HSP27.
Haiyi Fei, Yuhan Lin, Xiu Liu, Xiaohong Zhu, Xiaowen Lu, Zhan Shi, Fan Jia, Shiqian Xu, Ling Fang, Lingling Jiang, Songying Zhang   +10 more
wiley   +1 more source

Elevated levels of exogenous prolactin promote inflammation at the maternal-fetal interface via the JAK2/STAT5B signaling axis

Frontiers in Immunology
The placenta is a unique organ with various immunological and endocrinological roles that modulate maternal and fetal physiology to promote maternal-fetal tolerance, pregnancy maintenance, and parturition at term. During pregnancy, the hormone prolactin (
Alycia Williams, Daniel J. Hossack, Nia Thompson, Yul Eum Sim, Cristina Wilson, Viviane Schuch, Tiffany Hailstorks, Rana Chakraborty, Erica L. Johnson, Erica L. Johnson, Erica L. Johnson   +10 more
doaj   +1 more source

Term and Preterm Birth Initiation Is Associated with the Macrophages Shifting to M1 Polarization in Gestational Tissues in Mice

Biology, 2022
Inflammation in gestational tissues plays critical role in parturition initiation. We sought to investigate the leukocyte infiltration and cytokine profile in uterine tissues to understand the inflammation during term and preterm labor in the mouse model.
Yali Shan, Shiping Shen, Jing Long, Zhengshan Tang, Cichun Wu, Xin Ni   +5 more
doaj   +1 more source

Early Pregnancy Human Decidua Gamma/Delta T Cells Exhibit the Tissue Resident and Specific Functional characteristics [PDF]

, 2021
Shuo Yang, Ting Feng, Yong Cheng, Hao Tie Wang, Qin Hong Chen, Man Li Li, Yuan Liu, Bin Zhou, Rong Zhou, Hong Li   +9 more
openalex   +1 more source

Metabolic Reprogramming Driven by Trophoblasts and Decidual XCR1+PMN‐MDSC Crosstalk Controls Adverse Outcomes Associated With Advanced Maternal Age

Advanced Science, EarlyView.
The interaction between trophoblasts and decidual polymorphonuclear myeloid‐derived suppressor cells (dPMN‐MDSCs) via the XCL1–XCR1 axis is crucial for fetal development during the third trimester. Disruption of this axis impairs FOXO1 activity and causes metabolic imbalance in dPMN‐MDSCs, contributing to adverse outcomes associated with advanced ...
Meiqi Chen, Yuxiong Guo, Qing Zhao, Jingping Liu, Shuyi Kuang, Zhengcong Huang, Chenlin Lv, Shuxiu Xu, Zekai Zhuang, Anyan Yang, Jing Li, Kai Wu, Yumei He   +12 more
wiley   +1 more source

T lymphocytes in the third trimester decidua in preeclampsia

Hypertension in Pregnancy, 2019
Objective: The aim of study was to conduct immunohistochemical quantification of CD3+ and CD8+ decidual lymphocytes in preeclampsia. Methods: A study group included 30 cases of preeclampsia and a control group included 20 healthy pregnant women, all ...
Jelena Milosevic-Stevanovic, Miljan Krstic, Milan Stefanovic, Radomir Zivadinovic, Predrag Vukomanovic, Sonja Pop Trajkovic-Dinic, Slavica Stojnev   +6 more
doaj   +1 more source

Expression of Estrogen Receptor α by Decidual Macrophages in Preeclampsia

Biomedicines, 2021
Preeclampsia is a gestation-associated hypertensive syndrome that threatens the life and health of the mother and the child. The condition is presumably caused by systemic failure with a strong involvement of innate immunity.
Polina Vishnyakova, Anastasiya Poltavets, Maria Nikitina, Konstantin Midiber, Liudmila Mikhaleva, Kamilla Muminova, Alena Potapova, Zulfiya Khodzhaeva, Alexey Pyregov, Andrey Elchaninov, Timur Fatkhudinov, Gennady Sukhikh   +11 more
doaj   +1 more source

Caspase‐3/GSDME‐Mediated Trophoblast Pyroptosis and Reciprocal Macrophage Polarization Contribute to Inflammation in Early‐Onset Preeclampsia

Advanced Science, EarlyView.
In trophoblast cells, T/S (TNFα + SM164) activated caspase‐3, which cleaved GSDME to switch apoptosis to pyroptosis, causing cell swelling, membrane rupture, and release of LDH, HMGB1, IL‐1β and IL‐18. These cytokines induced pro‐inflammatory macrophage polarization, which in turn reinforced pyroptotic signaling in trophoblasts, amplifying systemic ...
Baoying Huang, Weinan Deng, Shilei Bi, Yifan Wang, Zhaowei Tu, Lijun Huang, Lili Du, Lizi Zhang, Zhoushan Feng, Wei Sun, Tengfei Liu, Julia Kzhyshkowska, Haibin Wang, Jingsi Chen, Dunjin Chen, Shuang Zhang   +15 more
wiley   +1 more source

Innate Immune Mechanisms to Protect Against Infection at the Human Decidual-Placental Interface

Frontiers in Immunology, 2020
During pregnancy, the placenta forms the anatomical barrier between the mother and developing fetus. Infectious agents can potentially breach the placental barrier resulting in pathogenic transmission from mother to fetus.
Regina Hoo, Regina Hoo, Annettee Nakimuli, Annettee Nakimuli, Roser Vento-Tormo, Roser Vento-Tormo   +5 more
doaj   +1 more source