Results 101 to 110 of about 3,649,113 (248)
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Controversias en teoría de la decisión y modelos diagramáticos de causalidad
Epistemología e Historia de la Ciencia, 2017 En esta comunicación, nos proponemos analizar la controversia entre los partidarios de la teoría evidencial de la decisión y los de la teoría causal de la decisión, a la luz de la denominada “Paradoja de Simpson”.
Adriana Spehrs
doaj
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Las Juntas de Conciliación y Decisión en Panamá
Estudios de Derecho, 1978 Las Juntas de Conciliación y Decisión en ...
Jorge Fábrega Ponce
doaj
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Personalidad y toma de decisiones vocacionales en universitarios [PDF]
, 2011 En este trabajo se analizan las relaciones entre la personalidad y la toma de decisiones vocacionales en estudiantes universitarios. La hipótesis de partida es que la personalidad eficaz está asociada a un proceso de toma de decisiones vocacionales más ...
Bethencourt Benítez, José Tomás +1 more
core +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Discrecionalidad, ciencia y sistema del derecho penal
Pensamiento Jurídico, 2017 Los teóricos del derecho penal casi de manera unánime sostienen que el derecho penal es una ciencia, dicha afirmación es fundamental para los términos en que se desarrolla su construcción, dado que la cientificidad permite a este conocimiento una ...
André Scheller D´Angelo
doaj