Results 141 to 150 of about 1,667,357 (297)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Differential Effects of Kinesthetic and Visual Motor Imagery Perspectives on Corticospinal Excitability in Healthy Adults

Brain Stimulation
Gleb Perevoznyuk, Ainur Ragimova, Artyom Batov, Aleksandra Pleskovskaya, Anthony Mensah, Daria Ponomareva, Matteo Feurra   +6 more
doaj   +1 more source

Decision Making in Pediatric Heart Failure and Transplant: A Qualitative Analysis of Parental Decision Making. [PDF]

Pediatr Transplant
Phillips KA, Lancaster E, Tuckett S, Galyean P, Zickmund SL, Molina KM, Pinto NM, Ozanne EM.   +7 more
europepmc   +1 more source

Clinical adolescent decision-making: parental perspectives on confidentiality and consent in Belgium and The Netherlands

, 2022
Jana Vanwymelbeke, David De Coninck, Koen Matthijs, Karla Van Leeuwen, Steven Lierman, Ingrid Boone, Peter de Winter, Jaan Toelen   +7 more
openalex   +2 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Clinical Decision-Making Case: Intussusception. [PDF]

J Educ Teach Emerg Med
Milman B, Parnell S.
europepmc   +1 more source

Emergency Decision Making [PDF]

Academic Emergency Medicine, 1994
openaire   +2 more sources

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Transitivity, contextuality and decision making. [PDF]

Philos Trans A Math Phys Eng Sci
Sulis WH.
europepmc   +1 more source

Critic-entropy based fuzzy decision making models: a systematic analysis

, 2021
J. Aldring, D. Ajay
openalex   +2 more sources