Results 211 to 220 of about 4,474,391 (330)

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source

Neurocomputational mechanisms of personal benefits and justifications in moral decision-making. [PDF]

Commun Biol
Sai L, Wang C, Lv Y, Bellucci G.
europepmc   +1 more source

Decision Making on the Efficacy and Safety of Drugs

, 1972
Harry F. Dowling
openalex   +1 more source

Ubiquitination of transcription factors in cancer: unveiling therapeutic potential

Molecular Oncology, EarlyView.
In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley   +1 more source

Decision-making Principles in Management [PDF]

, 2014
Dudnik, A.V., Kostrytska, S.I., Mala, Oksana   +2 more
core  

Decoding uncertainty for clinical decision-making. [PDF]

Philos Trans A Math Phys Eng Sci
Tsaneva-Atanasova K, Pederzanil G, Laviola M.   +2 more
europepmc   +1 more source

Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?

Molecular Oncology, EarlyView.
Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
wiley   +1 more source

Editorial: Digital health technologies for shared decision making. [PDF]

Front Digit Health
Cheetham M, Canhão H, Martin-Niedecken AL, Biller-Andorno N, Meier CA.   +4 more
europepmc   +1 more source

Trust and Participation in Organizational Decision Making as Predictors of Satisfaction [PDF]

, 1978
James W. Driscoll
openalex   +1 more source

Assistance with decision-making

Journal of Psychosomatic Obstetrics & Gynecology, 2005
Hbm van de Wiel, Wcm Weijmar Schultz
openaire   +4 more sources