Results 81 to 90 of about 1,667,357 (297)

Neural correlates of uncertainty processing: meta-analysis of fMRI studies

open access: yesFrontiers in Neuroscience
IntroductionUnderstanding the neural mechanisms underlying decision-making under uncertainty represents a fundamental challenge in cognitive neuroscience.
Andrey Timashkov   +2 more
doaj   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

open access: yesFEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Effectiveness of an object moving depending on its orientation in the environment: a kinematic analysis of motor planning and execution

open access: yesНервно-мышечные болезни
Background. Grasping objects with the hand is one of the most common movements in everyday life. It requires training involving the cognitive processes of goal selection and motor planning.Aim.
A. O. Vyazmin   +5 more
doaj   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

open access: yesFEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Shared decision-making in the intensive care unit requires more frequent and high-quality communication: A research critique [PDF]

open access: bronze, 2020
Julie Cussen   +4 more
openalex   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

open access: yesFEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Striatum-Mediated Deficits in Stimulus-Response Learning and Decision-Making in OCD [PDF]

open access: gold, 2020
Nole M. Hiebert   +6 more
openalex   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

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