Results 111 to 120 of about 12,247,021 (294)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Shared Decision-Making as a Model of Medical Decision-Making

Korean Journal of Medical Ethics, 2008
Matters related to human life and death and medical healing are the concerns of patients, physicians, and other related persons, including family members of the patients. Existing medical decision-making models include paternalism and informed consent. However, these models have the limitation of being one-sided or unidirectional. Accordingly, shared
openaire   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Implications of integrating large language models into clinical decision making

Communications Medicine
Christof & Armoundas explore how large language models (LLMs) can augment clinician-level clinical reasoning across the three pillars-framing the encounter, diagnostic reasoning, and treatment/management-highlighting gains in information synthesis and ...
Michael Christof, Antonis A. Armoundas
doaj   +1 more source

Trustworthiness Evaluation of Large Language Models Using Multi-Criteria Decision Making

IEEE Access
As Large language models (LLMs) become increasingly integrated into high-stakes applications, ensuring their trustworthiness has emerged as a critical research concern.
Meltem Aksoy, Aylin Adem, Metin Dagdeviren   +2 more
doaj   +1 more source

A new computer-based index for swimming pools' environmental health assessment in big data environment by consensus-based fuzzy group decision-making models. [PDF]

J Environ Health Sci Eng, 2021
Baghapour MA, Moeini Z, Shooshtarian MR.
europepmc   +1 more source

Outsourcing and acquisition models comparison related to IT supplier selection decision analysis [PDF]

, 2012
This paper presents a comparison of acquisition models related to decision analysis of IT supplier selection. The main standards are: Capability Maturity Model Integration for Acquisition (CMMI-ACQ), ISO / IEC 12207 Information Technology / Software Life
Calvo-Manzano Villalon, Jose Antonio, Grossi, Lucas Gonçalves   +1 more
core   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

The interaction of fuzzy logic with machine learning and artificial intelligence in decision-making models [PDF]

The employment of fuzzy logic is progressively gaining recognition as a prevalent and extensive methodology across a diverse spectrum of decision-making procedures.
Nalbant, Kemal Gokhan
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source